Leader-member exchange (LMX) is closely related to the motivation of the members. This study explains the effect of the LMX on the job satisfaction, which is connected to motivation. Moreover, we demonstrate the moderating effect of performance-oriented culture and relation-oriented culture in the relationship between LMX and job satisfaction. If the quality of the LMX is high, the members become more satisfied with the job. However, depending on the specific organizational culture, there will be differences in the influence or role of the LMX. Through the effect of organizational culture we explain the situations in which the LMX is more important, its influence is not important, or the LMX is unnecessary. The purpose of this study is to explain whether the organization should focus more on efforts to improve the quality of LMXs, or on factors other than LMX, depending on the culture characteristics of the organization.