Objective: The purpose of this study was to evaluate the relationship between quality of life (QoL) of the caregiver and disease severity with motor function in children with cerebral palsy (CP). Design: Cross-sectional study. Methods: Research data were collected in the Rehabilitation Clinic of Daegu University. The Gross Motor Function Measure (GMFM-88) and the functional independence measure (FIM) were used for assessment by three occupational therapists, and the 36-item short form health survey (SF-36) were applied to the caregivers. One hundred six caregivers of under 18 years who were diagnosed with CP completed a survey and interview. The caregivers’ QoL was evaluated using Medical Outcomes Study SF-36. The children’s motor function was scored using GMFM-88 in five dimensions: lying and rolling; sitting; crawling and kneeling; standing and walking, running and jumping and CP’s FIM scores. Results: Out of the 8 domains of the Medical Outcomes Study SF-36, the “physical functioning”, “physical role functioning”, “mental health”, and “bodily pain” domains were significantly correlated to “total” percentage scores of the GMFM-88 (p<0.05). In addition, the “mental health” domain was correlated to each subdomain of the GMFM-88, which includes, “lying and rolling”, and “crawling and kneeling”. Similarly, of Medical Outcomes Study SF-36, “physical functioning”, “bodily pain”, and “mental health” domains were significantly correlated with “transfer” and “locomotion” of FIM scores (p<0.05). Conclusions: This study showed that the QoL of the caregivers were well correlated with the motor function of children with CP. It is also important to support not only physical health but also psychological health of caregivers of children with CP, especially those with severe motor function.