Since mobile devices have become a learning tool with great potential in both classrooms and outdoor learning, mobile-mediated learning is undergoing rapid evolution. It is often argued that mobile devices are particularly suited to supporting social interactions and collaborative learning. Although there have been quantitative analyses of the use of mobile devices in the field of higher education, in-depth case study of the employment of mobile devices in the classroom context are still lacking. This study investigated university students perspectives to the effectiveness of blended learning (e-learning and mobile learning) in terms of their affective and cognitive aspects. Seventy two students in two content-based courses at a large university in Cheonan were involved in the semester-long study. As for the data collection, this study incorporated classroom observations, background questionnaires, and end-of-semester questionnaires. The results indicated that the participants had positive perceptions of mobile-mediated blended learning in terms of interests, motivation, and group interactions. Based on these findings, pedagogical implications for future higher education are posed.