In the hospital setting, the first witnesses of cardiac arrest are mostly nurses and should be knowledgeable and attentive about cardiopulmonary resuscitation to assist patients. The purpose of this study was to analyze the factors affecting the nurses performance of CPR in emergency situations in hospitals. Based on the results, I wanted to strengthen the ability of nurses to perform cardiopulmonary resuscitation. The study was conducted with 176 hospital nurses in 2 hospitals located in Busan. The survey data were analyzed using with the SPSS WIN 21.0 program. The results of this study, the significant factors influencing performance ability of CPR were ward, CPR experience, CPR confidence, CPR attitude. Those factors explained about 48.1% of the variance. It is necessary to establish a positive attitude about performing CPR and increase CPR confidence. In order to enhance the ability of CPR to perform CPR in nurses emergency situations, it is necessary to increase confidence in CPR performance. It is necessary to recognize positively that performing CPR to patients helps to save lives of patients. Therefore, I think that it is necessary for the nurses to repeat the cardiopulmonary resuscitation training and to implement the cardiopulmonary resuscitation performance.