This study is a quasi experimental study of the design of non - equality control postpartum time lag to confirm the effect of structured cold therapy on edema, inflammation and pain in patients with ankle fracture surgery. Study was conducted from August 19, 2016 to March 31, 2017. The research subjects were divided into experimental group (n=29) and control group (n=29). The structured cryotherapy using a cold gel pack in a plastic bag with a specially designed tarpaulin which can be molded around the ankle was applied. This intervention was performed 20 minutes followed by 40 minutes rest and repeated 10 times per day for 7 days after surgery. Statistical analysis was performed using the IBM SPSS Statistics 23.0 program. Hypothesis testing of the experimental group and the control group was based on repeated measures ANOVA. The change in subjective pain intensity did not satisfy the assumption of normality, and homogeneity was not confirmed, so it was analyzed by Generalized Estimating Equation. The results of this study showed that the application of structured cryotherapy to the ankle fractured patients after surgery was effective in reducing edema(F=36.02, p=.001) and decreasing the level of CRP(F=3.64, p=.039) and ESR(F=4.51, p=.013). While this intervention showed an effectiveness in relieving pain(Wald x²=13.995, p=.007), there was no statistical difference found from the frequency of taking pain killers(F=2.83, p=.098) in both experiment and control groups. This study contributes an evidence based practice of using structured cryotherapy as an effective postoperative nursing intervention in ankle fracture patients. To validate the effect of structured cold therapy, we propose an iterative study on patients who have had an ankle fracture surgery in the future.