With the advent of the Fourth Industrial Revolution, multi-variety production in the up-to-date manufacturing environment is proceeding more rapidly whereby production planning and management have been getting more complicated. Moreover, the need to improve production efficiency through effective operation sequencing is further heightened. Fundamentally, the effective operation sequencing can reduce the set-up of the equipment, efficiently utilize the equipment, shorten the set-up time, and ultimately contribute to productivity improvement. This study deals with the problem of efficient operation sequencing in a situation where a single machine performs multiple operations. The complexity of the problem is very high when compared to the case where only one operation is performed on one machine, which is covered in most existing studies. In this paper, we propose an integer programming model to minimize the number of setups. This study aims at minimizing the number of mold replacement times in the process of processing a given production order for the wiring harness manufacturing process, which is one of the components of automobile electric field. In addition, brief case studies are presented to verify the validity of the proposed mathematical model.