This research shows general discussions on what is mind-body medicine. The discussions include subconscious emotional life and spiritual dimension, let alone physical or mental health. However, the discussions focus on relationship between stress and health which is the theoretical background of mind-body medicine. So the great emphasis is put on psychoneuroimmunology which deals with relationship between mind, nerve system and immune system. This study illuminates some major concepts of mind-body medicine: self-regulation, stress response, diathesis-stress model, allostasis and allostasis load, emotion. In particular, an investigation is made into current perspectives on self-regulation and emotion with neurobiology of emotion, neurobiology of attachment, affect disregulation, therapeutic implication.