우리 몸은 ROS의 유해성으로부터 조직을 방어하 는 항산화효소(antioxidant enzyme)가 존재하며(Ji, 1993), 그 중 우리 몸에서 만들어지며 가장 중요한 역할을 하는 것이 SOD(superoxide dismutase)이다. 이것은 사립체(mitochondria)에서 생성되어 superoxide radical을 과산화수소(H2O2)와 물(H20) 로 분해한다(정해영, 1999). ROS는 세포고사 유발과 관계가 있음이 밝혀지고 있으며(Chhalliyil, Natarajan, & Govindaswamy, 2000), 산화스트레스에 의해 유발되는 세포고사 동안에 superoxide와 지질과산화(lipid peroxidation)는 증가한 다고 보고하였다(Ramanathan, Anusuyadevi, Shila, & Panneerselvam, 2005). 또한 노화와 관계가 깊은 산화 스트레스는 세포고사를 유도하는 주요인자이며, 세포 내 사립체가 세포고사의 억제와 촉진에 중요한 역할을 수행하는 것으로 알려져 있다(Fukuo, 2002).
The purpose of this study was to examine the response of antioxdant enzyme of SOD activity level and apoptotic gene expression of Bax mRNA by intense aerobic exercise. Subjects of this study were SD (sprague dawley) male rats and they were randomly assigned in groups (control group, n=6; intense exercise group, n=6). They performed intense aerobic exercise for 8 weeks. After exercise stability and forty-eight hour legitimacy, the soleus muscle was obtained following anesthesia by Ether. An independent t-test was utilized for analyses. As the results, the SOD activity level was significantly higher in the intense aerobic exercise group compared to the control group (p<.01). And the gene expression of apoptosis in Bax mRNA was significantly higher in the intense aerobic exercise group compared to the control group (p<.001). Therefore, increased antioxidant enzyme activity level and gene expression of apoptosis in Bax mRNA were positively influenced by intense aerobic exercise.
I. 서론 II. 연구방법 III. 연구결과 및 논의 IV. 결론 참고문헌
