The purpose of this study is to investigate how students’ career decision-making profiles(CDMP) affect their career decision-making difficulties. This study assumed that there would be cultural differences in career decision-making and thus compared the career decision-making processes of college students from Korea and the U.S. The subjects were 115 college students in Korea and 103 college students in the U.S. Hierarchical regression analysis was used to investigate the moderating effect of the nation. The results showed that there are significant differences in the career decision-making profiles of Korean and American college students; the U.S. college students exhibited a more effective career decision-making process than the Korean students. Second, there
were no significant differences in the factors of decision-making difficulties, but in the sub-factors, American students had difficulties as a result of personality problems. Meanwhile, Korean students had a lack of information about decision-making process, job information, and inconsistent information. Third, the results did not show us the moderating effect of the nation but Korean students were significantly affected by the inconsistent information. The results suggest that we can find ways to reduce the decision-making difficulties by understanding the level of the career decision-making profiles and the cultural differences between Korea and the U.S. Finally, the interaction between the two did not show a moderating effect, but Korean students were significantly affected by the inconsistent information. The results of this study imply ways of reducing career decision-making difficulties and increasing the career decision-making profiles effectively.