Cleft lip/palate patients require life-long multidisciplinary treatment to restore proper orofacial function and esthetics. Due to anatomical complexity and individual variation, conventional surgical techniques and supportive treatment cannot always guarantee ideal treatment results. Three-dimensional (3D) printing technology has driven major innovations in industry system, including medicine. Recent advances of bioprinting have enabled personalized tissue engineering and regenerative techniques. This review article provides an overview of 3D printing and bioprinting technology, including its application, limitation, and future perspectives in cleft lip/palate treatment.