Cleft lip and palate involves various and complex problems in craniofacial area and requires systematic management by experts in many fields from birth to growth completion. In addition, dental anomaly, which appears in various forms, complicates orthodontic treatment planning and acts as an important factor in prolonging the treatment period. The purpose of this case report is to show the long-term course of treatment and results of cleft lip and palate patients with various dental anomaly including maxillary peg lateralis, impaction of upper left canine, transposition of canine and lateral incisor, delayed formation of the upper left permanent premolar and palatal impaction. The patient had many uncertain factors that would change with growth to determine everything at the first visit, and received various treatment management for a period of about 10 years from the first visit to the Department of Orthodontics at 6 years and 10 months until 16 years and 10 months. The treatment goals were relatively clearly separated at each stage of treatment, with appropriate rest periods between treatment stages as needed. Appropriate modifications were made as needed within the overall treatment plan, and satisfactory results were obtained.