The technological innovation, called the Fourth Industrial Revolution, brings about changes in the labor market, including the reduction of jobs, the increase of job instability, and the expansion of atypical employment represented by platform labor. These threaten the sustainability of traditional social security policies that assume the full employment and standard employment relationships. This paper attempts to assess the impact of the labor market changes following the Fourth Industrial Revolution on employment of disabled persons, and discuss at a theoretical level how the employment guarantee and income security policies should respond to these changes. The reduction of jobs intensifies competition for simple repetitive jobs and low-wage and low-educated jobs, creating a disadvantage for employment of disabled persons and threatening the employment quota system for disabled persons based on permanent employment. Increasing job insecurity threatens the effectiveness of the workforce protection policy for workers with disabilities, based on workability, such as minimum wages and subsidies. Emerging platform-based atypical jobs are less accessible to disabled persons who are unable to move quickly and do not have a way to protect the rights of workers. The low level of education and employment of disabled persons are detrimental to new job competitions that require creativity. Ultimately, the crisis of employment and employment policy for disabled persons will increase the scope of income security for disabled persons, and if the disability assessment that determines the eligibility of income security is shifted to more reflecting the reality of the labor market, the beneficiaries of disability benefits will increase significantly. Therefore, it was suggested that a major change of the policy that separates job guarantee from the right to live is necessary, and a social security policy for disabled persons based on the basic income should be prepared. Although still exploratory, it is expected to be meaningfully accepted as a new issue in consideration of the Fourth Industrial Revolution in disability policies.