Objective: The purpose of this study was to examine how job stress, coping style, and social support were associated with quality of life among child care teachers. Methods: The participants were comprised of 281 child care teachers in the metropolitan area of Seoul. Job stress, problem-focused coping style, social support, and quality of life were assessed by a teacher-reported questionnaire. Results: Correlation and regression analyses revealed that while job stress predicted lower quality of life, having problem-focused coping style and family support enhanced quality of life among child care teachers. Furthermore, results showed significant moderation effects of support from directors at child care centers on the relationship between job stress and quality of life among child care teachers. Conclusion/Implications: The findings suggest the important role of problem-focused coping styles and family support in enhancing quality of life. Moreover, support from directors at child care centers appeared to buffer the effects of job stress on quality of life among child care teachers. Results were discussed in terms of their implications for educational and counseling programs for child care teachers.