It has been suggested that students pre-questions can elucidate their interests and needs. Students are the consumers of education and the science teaching-learning process positively affects their ability to develop scientific competence. As such, students’ pre-questions are important in science learning, but research on how to secure meaningful pre-questions that can be used in the teaching-learning process has not been conducted. Therefore, this study focused on ways to secure pre-questions for students that can be used for elementary science learning. Three types of questionnaires were produced, covering learning objectives, key terms, and learning content. The produced questionnaires were administered to three sixth-grade classes, and students pre-questions were collected. The collected pre-questions were classified into available pre-questions, unavailable pre-questions, unrelated questions, and misconception questions, based on pre-question classification criteria established by an expert group. Students thoughts on the questionnaire were investigated through in-depth interviews with the students in each group. Through this, three types of questionnaire characteristics were identified. As a result of examining the possibility of utilization in the science teaching- learning process, the students’ pre-questions from the key terms questionnaire were found to be the best in terms of quantity and quality. On the basis of this, we discuss the implications of teachers’ teaching-learning composition when conducting student-centered science classes.