Objectives: The purpose of this study is to identify the structural relationship between perceived spouse support, post-traumatic growth, resilience, and cognitive emotional regulation strategies of middle-aged adults with traumatic experience. Methods: For this, a questionnaire survey was conducted on 312 middle-aged adults with trauma experience in Seoul and Gyeonggi Province. 241 people who are married and maintain a common-law relationship were used as final data. Results: First, resilience was completely mediated in the relationship between perceived spouse support and post-traumatic growth of middle-aged adults with traumatic experience. Second, the adaptive cognitive emotional regulation strategy was completely mediated in the relationship between perceived spouse support and post-traumatic growth. Third, in the relationship between perceived spouse support and post-traumatic growth, resilience and adaptive cognitive emotional regulation strategies were sequentially completely mediated. Conclusions: Spousal support perceived based on the results of this study can be an influencing factor that can help change in post-traumatic growth of individuals who have experienced trauma, but such spouse support is not a direct influencing factor, but rather resilience and adaptive cognitive support. Through the sequential mediating effect of the emotion regulation strategy, it was confirmed that it can have a positive influence on the post-traumatic growth of individuals.