The purpose of this study is to explore what kind of experiences nursing students experience in the process of performing simulation practice using a high-fidelity patient simulator and standardized patients. To this end, focus group interviews with 19 4th-year nursing students of D University were conducted. After the interviews, a qualitative content analysis was conducted based on the method proposed by Elo and Kyngas (2008). The results showed that the topics commonly experienced in simulation practice using a high-fidelity patient simulator and standardized patients were: ‘Difficulty to concentrate’, ‘Immersion in the practice environment’, ‘Negative psychological change’, ‘Positive psychological change’, and ‘Improvement of nursing capacity’. The topics experienced only in simulation practice using a high-fidelity patient simulator were: ‘Improvement of clinical performance capability’ and ‘Insufficiency of reality in the practice environment’. The topics experienced only in simulation practice using standardized patients were: ‘The vividness communication’, ‘Performance of limited direct nursing skills’, and ‘SP s role proficiency’. Nursing students perceived the simulation practice as a process to cultivate the competency of pre-service nurses, but experienced difficulties in immersion, burdens and limitations, and several restrictions. For efficient simulation practice training, it is necessary to develop various scenarios, discuss efficient curriculum operation, and create an environment to maximize learning effects.