To explain the reason of the rise in suicides of early adults after COVID-19, this study focused on the reality that face-to-face interaction has been limited. This study examined whether the relationship among thwarted belongingness, meaning in life, suicidal ideation of college students is moderated by the level of extraversion. For this purpose, online survey data of 425 college students in Korea were analyzed. Although extraversion did not moderate the relationship between thwarted belongingness and suicidal ideation, it moderated the relationship between thwarted belongingness and meaning in life. Also the moderated mediating effect of extraversion was significant. In other words, extraverted students who experience thwarted belongingness might perceive a bigger decrease in meaning in life, which makes them more vulnerable to suicidal ideation. This finding is of note in that it showed extraversion which has been known to contribute to one’s well-being might not be able to protect individuals from the negative effect of thwarted belongingness.