This study focused on the psychological and emotional aspects of families raising children with rare diseases, and, in particular, from the perspective of family strength, the family resilience of families to adapt and endure despite the crisis and stress was seen as an important concept. Therefore, It was intended to conduct an transactional analysis program using horticulture that improves family resilience and verify its effectiveness. For psychological and emotional intervention of families with rare diseases, horticulture using natural materials was utilized, and programs were organized based on the theory of self-status and stroke, which are the main concepts of alternating current analysis, to find out what the effects were on the subconcepts of family resilience, the belief system, communication and organizational type. Verification of effectiveness of transactional analysis programs using horticulture was made with nonequvalent comparison group design. After conducting a preliminary family resilience test on experimental groups and comparison groups, the experimental group conducted a total of eight programs twice a week and two hours per session, and did not take any action on comparison groups. A follow-up examination was conducted after the end of the program to compare the changes in the front and back examinations of the two groups. Studies have shown that the transactional analysis program using horticulture is effective in improving family resilience of children with rare diseases. The belief system, communication and organizational type, which are subconcepts of family resilience, have all been significantly improved. In the belief system area, we examined family beliefs in the personality types of P, A, and C through self-status tests. Here and now, It became a factor that changed the belief system through new analysis and self-discovery with belief that has the ability to solve problems in accordance with the situation. In the communication process, the results were shown to help lead to daily changes in communication between family members through strokes and to make honest emotional expressions. In the organizational type, the stability of family roles, family cohesion and family resource scores increased, resulting in positive results for the meaning and role of the family. By using horticulture to organize programs, interest and concentration were possible, and the results could be carried out every time, which became a means of guiding achievement and change during the program.