Purpose: This study aimed to determine whether there was a difference in infection rates between periodic exchange of tracheostomy tubes every 14 days and every 28 days. Methods: We searched five electronic databases and reviewed the studies according to these criteria. The final three studies (one non-random control study and two guidelines) were selected. Results: The quality evaluation results were checked as recommendations for the two guidelines and as having a low risk of bias for one study. One study was also checked to be 2++ according to the Scottish Intercollegiate Guidelines Network. When the tracheostomy tube is exchanged every 28 days, there is insufficient evidence that the infection rate is high compared to the case of exchanging every 14 days. Conclusion: We recommend that patients have their tracheostomy tubes exchanged every 28 days. In the patient group at high risk of infection, the timing of the exchange should be determined according to the clinical condition of the patient.