This study investigated how art therapy using psycho-cybernetic model influenced self-expression and interpersonal anxiety of female university students. For this study, 15 university students attending school in Seoul were selected, and participants were divided into an experimental group and control group. Participants of in the experimental group were provided with a total 8 weekly classes; nothing was provided to participants in the control group. The Social Avoidance and Distress Scale (SADS) and the Assertive Behavior Assessment Scale (ABAS) were administered to all participants before and after the group therapy to assess whether the group art therapy is spurred statistically meaningful change. For experimental group, ASEA was also conducted. The Mann-Whiteny U test and the Wilcoxon signed-rank tests were conducted after the experiment to assess the scale of participants’ self-expression, and the art self-expression of the experimental group was significantly increased. There was, however, no significant change in scale among the control group. In this study, structured art therapy using PMAT was provided, and participants were allowed to express their feelings about uncertain conditions and interpersonal relationships. This study is meaningful because it showed that art therapy positively affects female university students’ interpersonal anxiety, self-expression, and art self-expression when focused on the psychological and social characteristics in a situation that lacks precedent. Based on the results of this study and future studies were discussed. Based on the results of this study and future studies were discussed.