This study investigated how acceptance and commitment group art therapy (ACAT) affected the depression and the parenting self-efficacy of mothers with children with disabilities. The study was conducted on 26 mothers whose children were inpatients at an S rehabilitation hospital, and the study subjects were separated into three groups. The experimental group (11 participants) participated in an ACAT, the comparison group (six participants) received respite care, and the control group (nine participants) did not receive any experimental treatment. The Korean Version of the Beck Depression Inventory and Parenting Sense of Competence were conducted before and after the program. The data were then analyzed using repeated measures analysis of variance (ANOVA), and the significance of the variables’ correlations was tested. Based on the analysis, the results of this study were follows. First, participation in the therapy showed a statistically significant reduction in depression among the experimental group’s subjects, but respite care was found to have no significant effect. Second, the mothers’ parental self-efficacy showed a statistically significant increase, while parental anxiety decreased. In comparison, respite care did not show significant effects on parental self-efficacy or parental anxiety. Based on these research results, the significance and limitations of this study were discussed.