This study focuses on the self-esteem of multicultural youth and analyzes the influence of family factors, school factors, and health factors on the self-esteem of multicultural youth. In particular, the study was conducted with a focus on whether health factors have a significant impact on the self-esteem of multicultural youth. As a result of the study, among individual and family factors, when both parents were foreigners and the economic level of the family perceived by multicultural youth increased, self-esteem increased. Regarding school factors, the higher their grades and the level of support students received from their teachers and friends, the higher the self-esteem of multicultural youth tended to be. Regarding health factors, students who responded more positively in their subjective health evaluation and students who were less concerned about current health problems (physical and mental problems) showed higher self-esteem, as well as explanations of personal family factors and school factors. Even after controlling for health factors, the subjective health evaluation of oneself and the level of concern about one's current health problems (physical and mental problems) explained the self-esteem of multicultural youth. In addition to many existing previous studies on the impact of demographic and sociological variables on the self-esteem of multicultural youth, this study examined what significant impact health factors have on the self-esteem of multicultural youth when controlling for family and school factors.