The purpose of this study is to analyze the characteristics of the depression change trajectory and potential class by change trajectory of multicultural adolescents, and to present predictive factors for depression in multicultural adolescents. To this end, data from the 2nd year (primary 5) to the 6th year (middle school 3) of the multicultural youth panel survey were used. In this study, the depression change of all multicultural adolescents is estimated through the analysis of the potential growth model Through the analysis of the growth mixture model, sub-potential growth classes showing different patterns of change within the entire group are categorized. We examined whether individual factors (self-esteem), environmental factors (family support, friend support, teacher support), and parenting factors (mother's parental efficacy) predict depression. The analysis results are as follows. First, the trajectory of depression change in multicultural adolescents was derived from three latent groups (initial depression low-level - incremental type, initial depression high-level - decremental type, and initial depression medium-level - maintenance type) over time. Second, it was found that multicultural adolescents' self-esteem, family support, friend support, and mother's parental efficacy predicted the trajectory of depression change. Based on the results of this study, an intervention plan for reducing depression according to predictive factors for each potential class of multicultural adolescents' depression change trajectory was suggested, and the significance and limitations of the study were described based on the results of the study.