This study aims to examine the correlation between the K-CBCL 6-18 Dysregulation Profile (DP) and parental factors, such as depressive symptoms, parenting stress, communication quality, and parental monitoring levels, among middle school students, and the differences in these factors between the DP and Non-DP groups. The participants were 1,066 first-year middle school students (560 boys and 506 girls) from the 2021 Panel Study on Korean Children (PSKC). The DP was calculated from the T-score sum of the Anxiety/Depression, Attention Problems, and Aggressive Behavior scales (AAA scales) of the K-CBCL 6-18. Research tools included the Depression Scale (K6), Parenting Stress Scale, Communication Quality subscale of the Inventory of Parent and Peer Attachment (IPPA), and Parental Monitoring Scale. The results of this study are as follows. First, DP had significant positive correlations with parental depressive symptoms and parenting stress, and significant negative correlations with communication quality and parental monitoring. Second, parents in the DP group had significantly higher depressive symptoms and parenting stress, and lower communication quality with mothers and parental monitoring levels compared to the Non-DP group. There was no significant difference in communication quality with fathers. This study highlights that parents of DP group students experience more severe psychological difficulties, emphasizing the need for improved communication and monitoring strategies.