Purpose: This study was conducted to identify how social support and depression influence self-care for older adults who received Percutaneous Coronary Intervention (PCI). Methods: Data were collected during October and November 2009 from 136 older adults who made a follow-up visit after receiving PCI from a tertiary hospital. Data analyses were done using t-test, ANOVA, and multiple linear regression. Results: The average score for self-care was 3.47 out of 5 points, and the lowest scored sub-domain on self-care was medication. The level of social support was 2.80 out of 4 points. More than half of the participants had depressive symptoms. There was a significant difference in self-care by income level (F=3.51, p=.017). The result of multiple linear regression showed that income and self-esteem support were significant factors influencing self-care; however, depression was insignificant. Conclusion: In order to enhance self-care of older adults with coronary artery diseases, strategies for economically vulnerable older adults are needed, including educational interventions, insurance coverage for cardiac rehabilitation programs, and policy support. Engaging in social participation and intervention programs to strengthen self-esteem will help older adults increase self-care capacity. Additionally, a strategy for enhancing medication self-care specifically for older adults should be considered.