Purpose: This study done to evaluate the learning ability of hospitalized elders who had Ⅳ fluid therapy and to compare it with younger adults. Knowledge and practice were evaluated to develop effective education strategies for elders. Method: The design for this study was a comparative experimental design with 30 hospitalized elders and 30 hospitalized adults who had fluid therapy. Until the participants were familiar with the name and effects of medication and were able to practice Ⅳ medication well, medication education was given every hour. Results: The outcome of the medication education was that the adults learned and practiced better and faster than the elders. But, there was a significant difference only in knowledge of effects of medication. In knowledge of name of medication and practice, there were no significant differences between the groups. If education was given two times or more, the elders completely achieved the knowledge and practice of the education content about the Ⅳ therapy that they received. Conclusions: This study showed that elders were slow learners but learned well. If the education was given two or more times, the elders were good learners.