The purpose of this study was to examine Anti-obesity effect of Comus Walteri Wanger extract supplementation on body weight and fat mass in normal and high-fat diet mice. Twenty C57BL/6J mice volunteered in this study. C57BL/6J mice were randomly divided into four groups: normal diet control group (NCG, n=5), normal diet and Cornus Walteri Wanger extract group (NEG, n=5), high-fat diet control group (HCG, n=5), high-fat diet and Cornus Walteri Wanger extract group (HEG, n=5). Primary outcomes including body weight and fat mass were treasured prior to and after the intervention through statistical analysis on one way ANOVA and paired t-test. This study showed following results that HCG, HEG increased body weight as contrasted with NeG, NEG. Furthenrore fat mass of HEG was higher than NeG, NEG. This findings suggest that Cornus Walteri Wanger extract aren't effective for treatment of obesity, Moreover it is possibility that Cornus Walteri Wanger extract supplimentation increase accumulation of fat in case of high-fat diet induced obesity, Therefore Comus Walteri Wanger extract is not useful as health supplement food for anti-obesity.