This study examined the effects of the decoding skills, reading fluency, and interest in English on reading comprehension. In addition, the mediating role of interest in English was examined. The reading measures were administered individually to 95 sixth grade students in Seoul, Korea to assess and analyse the students' decoding skills (Letter Naming Fluency, Phonemic Awareness, and Word Fluency), reading fluency (Oral Reading Fluency), and reading comprehension skills (E-LQ online test). The findings can be summarized as follows. First, multiple regression analysis revealed that
both decoding skills and reading fluency are highly correlated with reading comprehension skills. Among the subordinates of decoding skills Word Fluency showed the highest effect on reading comprehension skills. Secondly, simple regression showed that student interest in English does effect reading comprehension skills. Thirdly, the mediating role of an interest in English between the decoding skills and reading fluency respectively with reading comprehension was not statistically significant; however, interest in English showed a strong relationship with decoding skills, reading fluency, and reading comprehension skills. This can be explained by assuming that the correlation with decoding skills, reading fluency, and reading comprehension was so strong that the mediating effect of interest in English did not show statistically. There are limitations, therefore, in generalizing the effects as the results above indicate. The study was conducted with only 95 sixth grade students in one private elementary school; therefore, pedagogical and theoretical implications and recommendations for further research are presented.