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111.

Increase of Intracellular Ca2+ Concentration by Vibrio Vulnificus Cytolysin in Rat Platelets; Triggering Mechanism of Platelet Cytolysis

JinBongParkSooWanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 10 199-205 (7 pages)

JinBongParkSooWanChae 저
...
- 3,000원
Vibrio vulnificus cytolysin caused platelet cytolysis and increased intracellular calcium concentration ([Ca2⁢]]i) of rat platelets in a concentration-dependent manner. In the presence of V. vulnificus cytolysin (3 HU/ml), lactate dehydrogenase (LDH) activity was increased from 1.3⁑0.4% of control to 64.3⁑3.4% in platelet suspension buffer. In Ca2⁢-free platelet suspension buffer, however, V. vulnificus cytolysin did not induce [Ca2⁢]i increase and LDH release....
112.

Acute Pulmonary Responses in Vivo to Silica Complexed with H+, Zn2+, or Fe3+

JiheeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 8 183-189 (7 pages)

JiheeLee 저
...
- 3,000원
complexation did not significantly change the LDH activity and total protein. NO production in cultured bronchoalveolar lavage cells was elevated by 2-fold, following IT any of the silica treatments compared with the saline group. Furthermore, the steady-state levels of iNOS mRNA in the lavage cells were greatly increased. There were any differences in iNOS mRNA expression among the silica-treated groups as with NO production. These findings suggest that surface complexed iron may not influence...
113.

The Effects of Sera from Amyotrophic Lateral Sclerosis Patients on Neuromuscular Transmission and Calcium Channels in Mice

HaiDunYan, JimokKim, SungJunJung, JunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 17 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 13 101-117 (17 pages)

HaiDunYan, JimokKim, SungJunJung, JunKim 저
...
- 4,600원
Amyotrophic lateral sclerosis (ALS) is a degenerative neuromuscular disease of unknown etiology in which the upper and lower motor neurons are progressively destroyed. Recent evidences support the role of autoimmune mechanisms in the pathogenesis of ALS. This study investigated the effects of sera from ALS patients on neuromuscular transmission in phrenic nerve-hemidiaphragm preparations and on calcium currents of single isolated dorsal root ganglion (DRG) cells in mice. Mice were injected with...
114.

Inducible Nitric Oxide Synthase mRNA Expression and Nitric Oxide Production in Silica-Induced Acute Inflammatory Lung Injury

JiheeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 12 233-239 (7 pages)

JiheeLee 저
...
- 3,000원
the lavage fluid obtained from silica-treated rats, indicating silica-induced acute lung injury. Northern blot analysis demonstrated that the steady state levels of iNOS mRNA in broncho-alveolar lavage cells were increased following silica treatment. The productions of nitrite and nitrate in the cultured cells were significantly increased by 2-fold following silica treatment, respectively, which were attenuated by the NOS inhibitor Nω-nitro-L-arginine-methyl ester(L-NAME) and partially reversed...
115.

Effect of pH on the ATP-sensitive K+ Channel in Aortic Smooth Muscle Cells from Rats

SeHoonKim, IlSuKim, HoeSukKim, ByeongHwaJeon, SeokJongChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 11 555-563 (9 pages)

SeHoonKim, IlSuKim, HoeSukKim, ByeongHwaJeon, SeokJongChang 저
...
- 3,000원
The effects of pH on K⁢ currents were investigated in single smooth muscle cells isolated from the thoracic aorta of Wistar-Kyoto rats. Whole-cell K⁢ currents were recorded in the conventional configuration of the voltage-clamp technique. Pinacidil (10uM) activated the whole-cell current and the pinacidil-activated current was completely inhibited by glibenclamide (10uM) , an inhibitor of ATP-sensitive K⁢ channel (KATP channel). Pinacidil-activated current was reversed at near...
116.

Mechanisms Underlying Relaxations Caused by Angiotensin II and Its Analogs in Isolated Rabbit Mesenteric Artery

KiWhanHong, , JiYoungPark, ChiDaeKim, WonSukLee, ByungYongRhim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 6 393-402 (10 pages)

KiWhanHong, , JiYoungPark, ChiDaeKim, WonSukLee, ByungYongRhim 저
...
- 3,000원
In the present study, we characterized the angiotensin II (AII)-induced relaxations in the phenylephrine- precontracted rabbit mesenteric arteries with endothelium. 1) AII-induced relaxation was consistently observed in the rabbit mesenteric arteries with and without endothelium, but not in the aortic segment with endothelium. 2) AII-induced endothelium-dependent relaxation was markedly inhibited by Nw-nitro- L-arginine (L-NNA, 100 ㄍM), methylene blue (10 ㄍM) and LY83583 (10...
117.

Effect of Cisplatin on Sodium-Dependent Hexose Transport in LLC-PK1 Renal Epithelial Cells

SukKyuLee, JeeYeunKim, TaiHyunYu, KyoungRyongKim, KwangHyukKim, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 5 35-43 (9 pages)

SukKyuLee, JeeYeunKim, TaiHyunYu, KyoungRyongKim, KwangHyukKim, YangSaengPark 저
...
- 3,000원
in the Na+-independent uptake. Kinetic analysis indicated that Vmax was suppressed, but Km was not altered. The Na+-dependent phlorizin binding was also decreased in cisplatin-treated cells. However, the AMG efflux from preloaded cells was not apparently retarded by cisplatin treatment. These data indicate that the cisplatin treatment impairs Na+-hexose cotransporters in LLC-PK1 cells and suggest strongly that defects in transporter function at the luminal plasma membrane of the proximal tubular...
118.

정신분열병 환자의 우울증에서 Paroxetine과 삼환계 항우울제 병용치료

심주철, 공보금, 박정환, 윤영란, 신재국, 김정익, 안동성, 김용관, 차인준, 김영훈 대한신경정신의학회 신경정신의학 10 Pages

대한신경정신의학회 신경정신의학 1997, 제 36권 제 4호 14 732-741 (10 pages)

심주철, 공보금, 박정환, 윤영란, 신재국, 김정익, 안동성, 김용관, 차인준, 김영훈 저
...
- 3,000원
저자들은 마산동서병원에 입원중인 우울증이 동반된 정신분열증 환자 10명을 대상으로 사용중인 항정신병 약물에 paroxetine과 저용량의 삼환계 항우울제를 6주간 병용투여한 후 우울증상에 대한 효과와 치료의 안 전성 및 약물상호작용을 알아보았다. Paroxetine은 고정량의 항정신병약물과 삼환계 항우울제에 부가하여 일일 20mg을 6주간 병용하게 하였으며, 임상상태는 HDRS, HARS, UKU Side Effect Rating Scale 등의 평가척도를 사용하여 평가하였다. 또한 약동학적 약물상호작용은 삼환계 항우울제들의 혈장농도를 HPLC로 측정하여...
119.

Tourette 장애 소년에서 자기 공명 영상을 이용한 대뇌와 소뇌의 분할 용적 분석

이정섭, 정선주, 강민희, 김철응, 임명관, 서창해, 조수철, 홍강의 대한신경정신의학회 신경정신의학 9 Pages

대한신경정신의학회 신경정신의학 2002, 제 41권 제 2호 7 254-262 (9 pages)

이정섭, 정선주, 강민희, 김철응, 임명관, 서창해, 조수철, 홍강의 저
...
- 3,000원
연구목적： Tourette 장애(이하 TD)의 신경 병리학적인 원인으로 뇌 속의 단일 부위의 이상이라기보다는 기 저핵과 대뇌를 연결하는 신경망에 이상이 있을 것이라는 가설을 입증하기 위하여 본 연구를 시행하였 다. 본 연구에서는 TD가 있는 소년과 대조군에서 자기 공명 영상을 이용하여 대뇌와 소뇌를 10개의 관심영역으로 분할하여 용적과 대칭성을 측정하였다. 방 법： TD가 있는 19명의 남자 환아와 연령을 짝지은 17명의 건강한 대조군을 대상으로 하였으며, 여러가 지 변인들(손잡이, 약물의 효과, 동반된 정신장애 등)을 통제를...
120.

초발 정신분열병 환자에서 자기공명영상을 이용한 뇌용적 분석

신상은, 강민희, 이정섭, 김철응, 배재남, 최성욱 대한신경정신의학회 신경정신의학 16 Pages

대한신경정신의학회 신경정신의학 2002, 제 41권 제 5호 12 847-862 (16 pages)

신상은, 강민희, 이정섭, 김철응, 배재남, 최성욱 저
...
- 4,500원
연구목적： 항정신병 약물을 사용하지 않은 초발 정신분열병 환자들을 대상으로 대뇌와 소뇌의 용적을 측정하 여 초기 정신분열병 환자의 뇌의 형태학적 특성을 분석하여 정신분열병의 구조적 병인을 정립할수 있 는 자료를 제공하도록한다. 방 법： 총 25명의 정신분열병 환자(평균 연령：31.20±7.85세, 연령의 범위：18~44세)와 29명의 정상 대조군(평균 연령：29.03±7.02세, 연령의 범위：18~42세)을 대상으로 용적의 분할을 시행하였다. 대 뇌와 소뇌를 회색질, 백색질 및 뇌척수액을 확률적인(probabilistic) 조직의...

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