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본문검색 결과만 보기
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Effect of Cyclic GMP on the Calcium Current in Rabbit Ventricular Myocytes
Han, Jin, Leem, Chae-Hun, Ahn, Chul-Soo, So, In-Suk, Kim, Eui-Yong, Ho, Won-Kyung, Earm, Yung-E 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 4 151-162 (12 pages)
In order to investigate the effect of intracellular cyclic GMP on calcium current the whole-cell patch clamp technique with internal perfusion method was used in isolated ventricular myocytes of the rabbit. Cyclic GMP, 8-bromo-cyclic GMP, cyclic AMP, isoprenaline and forskolin were perfused into cells and their effects on calcium current were analysed by applying depolarizing step pulses of + 10 mV in amplitude far 300 msec from holding potential of - 40 mV. Not only cyclic AMP (100 μM) but... -
Effect of Dopamine on the Ca2+-dependent K+ currents in Isolated Single Gastric Myocytes of the Guinea-pig
Rhee, Poong-Lyul, Lee, Sang-Jin, Kim, Sung-Joon, So, In-Suk, Hwang, Sang-Ik, Kim, Ki-Whan 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 3 139-150 (12 pages)
current, which might reflect the changes of intracellular calcium concentration, was enhanced by dopamine. This effect was abolished by phentolamine. 5) The enhancing effect of dopamine on the Ca2+ -dependent K+ current disappeared with heparin which is known to block the action of InsP3. From these results, it is suggested that dopamine acts via InsP3-mediated Ca2+ mobilization from intracellular stores and such action potentiates the spontaneous contraction of guinea-pig gastric smooth muscle. -
Effects of Noradrenaline on the Spontaneous Contraction and Ionic Current in the Antral Circular Muscle of Guinea-pig Stomach
Jun, Jae-Yeoul, Lee, Sang-Jin, Kim, Sung-Joon, Suh, Jae-Yul, So, In-Suk, Hwang, Sang-Ik, Kim, Ki-Whan 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 1 115-122 (8 pages)
of this excitatory action, slow waves and membrane currents were recorded using conventional microelectrode techniques in muscle strips and the whole cell patch clamp technique in isolated gastric myocytes. On recording slow waves, noradrenaline (10-5 M) induced the hyperpolarization of the membrane potential, although the shape of the slow waves became tall and steep. Also, spike potentiaIs occurred at the peaks of slow waves. These changes were completely reversed by administration of... -
Acute and Chronic Effects of Ethanol on the Cardiovascular and Hormonal Responses to Hemorrhage in Conscious Normotensive and Spontaneously Hypertensive Rats
Park, Yoon-Yub, Lee, Joong-Hee, Park, Jae-Sik, Yang, Eun-Kyoung, Ahn, Dong-Kuk, Kim, Hyeong-Jin, Lee, Won-Jung, 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 7 67-78 (12 pages)
Acute and chronic effects of ethanol (EOH) administration on the cardiovascular and hormonal responses to repeated hemorrhage were investigated in conscious normotensive Wistar rats and spontaneously hypertensive rats (SHR). The chronic EOH treated group received 5% EOH (vol/vol) ad libitum in the drinking water far the first week,10% for the last 2 weeks, and 20% for the last 5 weeks from the age of 6 weeks. The EOH free group received tap water. Chronic EOH and EOH free groups were randomly... -
Effects of the Endothelium on the Contractile Responses to Norepinephrine in Isolated Proximal and Distal Coronary Artery of Pigs
Kim, Jong-Hoon, Jeon, Byeong-Hwa, Chang, Seok-Jong, Park, Hae-Kun 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 3 27-36 (10 pages)
Effects of the endothelium on the contractile responses to norepinephrine (NE) were investigated in isolated helical strips of the proximal and distal coronaries artery of pigs. The helical strips were immersed in Tris-buffered Tyrode s solution equilibrated with 100% O2 at 35℃ and its isometric tension was measured. NE relaxed the strips precontracted with acetylcholine from both the proximal and distal coronary artery. NE-induced relaxation, which might be induced mainly by β-adrenoceptor... -
Electrophysiological Study on Medullospinal Tract Cells Related to Somatosympathetic Reflex in the Cat
Kim, Sang-Jeong, Goo, Yong-Sook, Kim, Jun 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 8 75-88 (14 pages)
of the second thoracic (T2) spinal cord in anesthetized cats. Peripheral nerves were stimulated for orthodromic activation of these cells and peripheral receptive fields were determined. Post R wave histogram of unit and spike triggered averaging of sympathetic nerve discharge (SND) were used to define sympathetic related cell. A total of 113 neurons was recorded in ventrolateral medulla that had the axonal projections to T2 spinal cord. Thirty four of these medullospinal cells showed spontaneou... -
Central Pressor Mechanisms of Bradykinin in 2-Kidney, 1 Clip Goldblatt Hypertensive Rats
Yeum, Cheol-Ho, Jun, Jae-Yeoul, Yoon, Pyung-Jin 대한생리학회 대한생리학회지 6 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 7 69-74 (6 pages)
the pressor effect in GHR. Pretreatment with indomethacin (10mg/kg, intraperitoneally) or saralasin (20μg/kg/min, IV) was without effects on the pressor response to bradykinin. These results indicate that the central pressor effect of bradykinin is, at least in part, due to excitation of the autonomic nervous activity. Mechanisms other than the enhanced sympathetic nervous activity ran. not be ruled out, However. It is also suggested that the sensitivity to bradykinin is increased in the GHR. -
Ionic Dependence and Modulatory Factors of the Background Current Activated by Isoprenaline in Rabbit Ventricular Cells
Leem, Chae-Hun, Lee, Suk-Ho, So, In-Suk, Ho, Won-Kyung, Earm, Yung-E 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1992, 제 26권 제 1호 2 15-26 (12 pages)
In order to elucidate the properties of the background current whole cell patch clamp studies were performed in rabbit ventricular cells. Ramp pulses of ±80 mV from holding potential of 40 mV(or 20 mV) at the speed of 0.8 V/sec were given every 30 sec(or 10 sec) and current-voltage diagrams(I-V curve) were obtained. For the activation of the background current isoprenaline, adenosine 3 ,5 -cyclic monophosphate(dBcAMP), guanosine 3 ,5 -cyclic monophosphate(cGMP), and N6-2 -o-dibutyryladenosine 3... -
The Electrophysiological Characteristics of Medullospinal Tract Cells in Cat Ventrolateral Medulla
Lee, Woo-Yong, Kim, Sang-Jung, Kim, Jun 대한생리학회 대한생리학회지 11 Pages
대한생리학회 대한생리학회지 1991, 제 25권 제 2호 11 211-221 (11 pages)
Although the existence of nerve cells which determine the activity of sympathetic nervous system in ventrolateral medulla is advocated recently, there are wide varieties on the location and function of them according to authors. Present study aimed to identify and characterize the medullospinal tract cells in rostral and caudal medulla of cats .which branch to the lateral horn of the upper thoracic spinal cord. Cats were anesthetized with α-chloralose. The upper thoracic spinal cord and floor... -
기니피그 유문동에서 기록되는 억제성 접합부 전압에 미치는 전해질과 약물의 효과
구용숙(Goo, Yong-Sook), 서석효(Suh, Suk-Hyo), 이석호(Lee, Suk-Ho), 황상익(Hwang, Sang-Ik), 김기환(Kim, Ki-Whan) 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1990, 제 24권 제 1호 1 1-14 (14 pages)
기니피그 유문동 부위를 절제한 뒤 점막층을 박리하고 윤상근 주행방향으로 길이 10 mm, 너비 2 mm 되는 조직 절편을 만들어 수평형 실험용기에 넣어 핀으로 고정하였다. 유리미세전극을 세포내에 삽입하여 서파를 기록하면서 조직양편에 설치한 백금자극전극(직경 0.5 mm)에 강도 10 ~ 50V$, 기간 50 ~ 100 μs 되는 자극파를 주어 신경-근 부위의 접합부 전압을 기록하여 다음과 같은 결과를 얻었다. 1) 위저부에서는 흥분성 접합부 전압이, 유문동에서는 억제성 접합부 전압이 기록되었고 유문동의 억제성 접합부 전압은 atropine(10-6...
