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The Mechanism of t-Butylhydroperoxide-Induced Apoptosis in IMR- 32 Human Neuroblastoma Cells
Jung-AeKim, YongSooLee, KeunHuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 3 19-28 (10 pages)
Apoptosis has been implicated in the pathophysiological mechanisms of various neurodegenerative diseases. In a variety of cell types, oxidative stress has been demonstrated to play an important role in the apoptotic cell death. However, the exact mechanism of oxidative stress-induced apoptosis in neuronal cells is not known. In this study, we induced oxidative stress in IMR-32 human neuroblastoma cells with tert- butylhydroperoxide (TBHP), which was confirmed by significantly reduced... -
Protective Mechanism of Nitric Oxide and Mucus against Ischemia/ Reperfusion-Induced Gastric Mucosal Injury
HyeyoungKim, KwangsooNam, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 13 511-519 (9 pages)
This study investigated the role of nitric oxide on the oxidative damage in gastric mucosa of rats which received ischemia/reperfusion and its relation to mucus. Nitric oxide synthesis modulators such as L-arginine and NG-nitro-L-arginine methyl ester, and sodium nitroprusside, a nitric oxide donor, were injected intraperitoneally to the rats 30 min prior to ischemia/reperfusion which was induced by clamping the celiac artery and the superior mesenteric artery for 30 min and reperfusion for 1... -
Ethanol Prevents from Acetaminophen Inducible Hepatic Necrosis by Inhibiting its Metabolic Activation in Mice
Sun-MeeLee, Tai-SoonCho, Young-NamCha 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 15 261-269 (9 pages)
Concomitant administration of a single acute dose of ethanol (4 g/kg) protected mice from the hepatocellular injury observed upon administration of a large dose of acetaminophen (400 mg/kg). This was evidenced by the normal histological appearances of liver sections and by the lowered serum aminotransferase activities in mice treated with ethanol and acetaminophen together. In the mice treated with acetaminophen alone, along with the hepatic necrosis, the hepatic microsomal aminopyrine... -
Hypoxia-Induced EDNO Release is Further Augmented by Previous Hypoxia and Reoxygenation in Rabbit Aortic Endothelium
JaeJinHan, SukHyoSuh, KyungPhilSuh, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 9 209-216 (8 pages)
as a bioassay test ring. The test ring was contracted by prostaglandin F2α (3×10-6 M/L), which was added to the solution perfusing through the aortic segment. Hypoxia was evoked by switching the solution aerated with 95% O2/5% CO2 mixed gas to one aerated with 95% N2/5% CO2 mixed gas. When the contraction induced by prostaglandin F2α reached a steady state, the solution was exchanged for hypoxic one. And then, hypoxia and reoxygenation were interchanged at intervals of 2 minutes (intermittent... -
Effect of Panax ginseng on Latency of Passive Avoidance Response and Neuronal Damage of Hippocampus
So-HyunCho, Sang-HyunChoi, Jae-WonChoi, Dong-HoonKim, Kyung-HoShin, Yeon-SookChun, Boe-GwunChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 1 345-353 (9 pages)
The effects of crude saponin (SAP) and alkaloid (ALK) fractions of Panax ginseng C.A. Meyer on the detrimental effects of electroconvulsive shock (ECS) and scopolamine on passive avoidance response (PAR) were studied in male Sprague-Dawley rats, referring their effects on the neuronal injury and plasticity of hippocampus in response to electrolytic lesion of left entorhinal cortex (ECL). The detrimental ECS effect on PAR was attenuated by pre- and post-treatments with SAP and ALK, respectively,... -
Inhibition of Phospholipase A2 Diminishes the Acute Alveolar Injury Induced by Interleukin-1
YoungManLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 9 71-78 (8 pages)
In an attempt to investigate the role of phospholipase A2(PLA2) in interleukin-1 (IL-1) induced acute lung injury, mepacrine was tried to inhibit PLA2 in IL-1 induced ARDS rats. For confirmation of acute lung injury by IL-1, and to know the role of neutrophils in this injury, lung leak index, lung myeloperoxidase(MPO), number of neutrophils and protein content in the bronchoalveolar lavage (BAL) and wet lung weight were measured. At the same time lung PLA2 was measured to know the effect of... -
Effect of Cisplatin on Sodium-Dependent Hexose Transport in LLC-PK1 Renal Epithelial Cells
SukKyuLee, JeeYeunKim, TaiHyunYu, KyoungRyongKim, KwangHyukKim, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 5 35-43 (9 pages)
Cis-dichlorodiammine platinum II (Cisplatin), an effective chemotherapeutic agent, induces acute renal failure by unknown mechanisms. To investigate direct toxic effects of cisplatin on the renal proximal tubular transport system, LLC-PK1 cell line was selected as a cell model and the sugar transport activity was evaluated during a course of cisplatin treatment. Cells grown to confluence were treated with cisplatin for 60 min, washed, and then incubated for up to 5 days. At appropriate... -
Carbamazepine에 의한 독성 표피 괴사융해증 1례
박경신, 김창기, 기선완, 배종훈 대한신경정신의학회 신경정신의학 4 Pages
대한신경정신의학회 신경정신의학 1997, 제 36권 제 5호 18 948-951 (4 pages)
저자들은 Carbamazepine을 임상에서 사용하면서 가장 심각하게 문제가 되는 독성 표피 괴사융해증 1례 를 경험하였기에 문헌 고찰과 함께 보고 하였다. 정신과 영역에서 Carbamazepine의 사용이 증대함에 따라 많은 부작용이 보고 될 것이다. Carbamazepine 치료 중에 기본적인 혈액 검사, 전해질 검사, 간 기능 검사, 심전도, 뇌파 검사, 적절한 혈증 농도 검사와 세심한 임상적 주의가 부작용을 최소화하고 치료 효과를 크게 할 것이고 독성 표피 괴사융해증이 의심될 경우에는 혈액 전문의와 전문의에게 자문 의뢰하는 것이 필요할... -
잠재성 간성혼수 환자의 인지기능과 양성자 자기공명분광 소견과의 상관관계
김성윤, 정범석, 서동완, 이정희, 이철 대한신경정신의학회 신경정신의학 12 Pages
대한신경정신의학회 신경정신의학 1998, 제 37권 제 6호 19 1201-1212 (12 pages)
연구목적： 잠재성 간성혼수 환자들의 신경인지기능 장애 정도와 기저핵이나 두정엽 백질부에서의 자기공명분광 (proton MRS)으로 측정한 양성자 함유 화합물의 변화와의 상관관계를 조사하고자 하였다. 방 법： 한국판 웩슬러 지능 검사(KWIS) 중 토막짜기나 기호 바꾸기, 그리고 번호잇기 검사를 적용하여 잠재성 간성혼수로 정의된 18명의 간경변 환자를 대상군으로 하고 20명의 정상인을 대조군으로 하였다. 복합주의력 과 시각 정보 분석능력 측정을 위해 Vienna 전산화 신경인지기능 검사 중 Cognitrone 검사, 미세 협응 운동...
