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281.

Role of STAT3-Interacting Protein (STIP1) in Δ12-Prostaglandin J2-Induced Cell Death

Seong-MookKim, SunLee, Hwan-JongKwak, Bo-EunKim, Dong-JinKim, In-Kyung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 5 27-31 (5 pages)

Seong-MookKim, SunLee, Hwan-JongKwak, Bo-EunKim, Dong-JinKim, In-Kyung 저
...
- 1,500원
Δ12-Prostaglandin J2 (Δ12-PGJ2) is one of cyclopentenone prostaglandins. The Δ 12-PGJ2 is known to induce apoptosis of tumor cells, however, it's action mechanism is not clear. It has recently been reported that STAT3 is involved in tumorigenesis. In the present study, we investigated the role of STAT3-interacting protein (STIP1) in the cytotoxicity of Δ 12-PGJ2, since STIP1 was recently reported as a modulator of STAT3 activation by specifically binding to inactive (unphosphorylated) STAT3....
282.

Inhibition of DNA-dependent Protein Kinase by Blocking Interaction between Ku Complex and Catalytic Subunit of DNA-dependent Protein Kinase

Chung-HuiKim, DangVanCuong, Jong-SuKim, NariKim, EuiyongKim, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 3 9-14 (6 pages)

Chung-HuiKim, DangVanCuong, Jong-SuKim, NariKim, EuiyongKim, JinHan 저
...
- 3,000원
sensor-transmitting damage signal to downstream targets, leading to cell cycles arrest. Our ultimate goal is to develop a treatment of breast tumors by targeting proteins involved in damage-signaling pathway and/or DNA repair. This would greatly facilitate tumor cell cytotoxic activity and programmed cell death through DNA damaging drug treatment. Therefore, we designed a domain of Ku80 mutants that binds to Ku70 but not DNA end binding activity and used the peptide in co-therapy strategy to see...
283.

Ceramide is involved in MPP+-induced Cytotoxicity in Human Neuroblastoma Cells

Eun-JooNam, Hye-SookLee, YoungJaeLee, Wan-SeokJoo, SunghoMaeng, Hye-InIm, Chan-WoongPark, YongSikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 1 281-286 (6 pages)

Eun-JooNam, Hye-SookLee, YoungJaeLee, Wan-SeokJoo, SunghoMaeng, Hye-InIm, Chan-WoongPark, YongSikKim 저
...
- 3,000원
To understand the cytotoxic mechanism of MPP⁢, we examined the involvement of ceramide in MPP⁢- induced cytotoxicity to human neuroblastoma SH-SY5Y cells. When SH-SY5Y cells were exposed to MPP⁢, MPP⁢ induced dose-dependent cytotoxicity accompanied by 2-fold elevation of intracellular ceramide levels in SH-SY5Y cells. Three methods were used to test the hypothesis that the elevated intracellular ceramide is related to MPP⁢-induced cytotoxicity: C2-ceramide was...
284.

The Preventive Effects of Bcl-2 and Bcl-xL on Lovastatin-induced Apoptosis of C6 Glial Cells

JaeWonChoi, JongMinLee, YoungJunOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 1 235-240 (6 pages)

JaeWonChoi, JongMinLee, YoungJunOh 저
...
- 3,000원
It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25μM)- induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation...
285.

Phytoestrogen-Induced Phosphorylation of MAP Kinase in Osteoblasts is Mediated by Membrane Estrogen Receptor

YounHeePark, HwanKiPark, HyoJinLee, SunMuPark, SangWonChoi, WonJungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 7 165-170 (6 pages)

YounHeePark, HwanKiPark, HyoJinLee, SunMuPark, SangWonChoi, WonJungLee 저
...
- 3,000원
We have previously demonstrated that phytoestrogens isolated from safflower seeds significantly attenuated bone loss in ovariectomized rats, and directly stimulated proliferation and differentiation of cultured osteoblastic cells. In an attempt to elucidate underlying cellular mechanisms, in the present study we investigated effects of 17β-estradiol (E2) and phytoestrogens such as matairesinol and acacetin, a type of lignan and flavonoid, respectively, on activation of mitogen activated...
286.

Effect of Sedative Dose of Propofol on Neuronal Damage after Transient Forebrain Ischemia in Mongolian Gerbils

Seong-RyongLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 10 73-79 (7 pages)

Seong-RyongLee 저
...
- 3,000원
This study investigated whether propofol, an intravenous, non-barbiturate anesthetic, could reduce brain damage following global forebrain ischemia. Transient global ischemia was induced in gerbils by occlusion of bilateral carotid arteries for 3 min. Propofol (50 mg/kg) was administered intraperitoneally 30 min before, immediately after, and at 1 h, 2 h, 6 h after occlusion. Thereafter, propofol was administered twice daily for three days. Treated animals were processed in parallel with...
287.

Activation of SAPK and Increase in Bak Levels during Ceramide and Indomethacin-Induced Apoptosis in HT29 Cells

JuHoKim, SaeOckOh, SungSookJun, JinSupJung, JaeSukWoo, YongKeunKim, SangHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 10 75-82 (8 pages)

JuHoKim, SaeOckOh, SungSookJun, JinSupJung, JaeSukWoo, YongKeunKim, SangHoLee 저
...
- 3,000원
It has been reported that activation of sphingomyelin pathway and nonsteroidal anti-inflammatory drugs (NSAIDS) inhibit the promotion of colon carcinoma. Ceramide, a metabolite of sphingomyelin, and indomethacin were shown to induce apoptosis in colon carcinoma cells. However, the mechanisms of ceramide- and indomethacin-induced apoptosis in the colon carcinoma cells are not clearly elucidated. Recent studys showed that indomethacin-induced apoptosis in colon cancer cells through the...
288.

Mouse Leukemia 세포에서 Adenosine 5’-triphosphate에 의 한 Apoptosis

주난영, 박규상, 정해숙, 공인덕, 이중우 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 23 817-824 (8 pages)

주난영, 박규상, 정해숙, 공인덕, 이중우 저
...
- 3,000원
Apoptosis Induced by Adenosine 5’-triphosphate in Mouse Leukemic Cells. Nan Young Joo， Kyu Sang Park， Hae Sook Chung， In Deok Kong， and Joong Woo Lee Department of Physio1ogy， Yonsei University W onju College of Medicine， W onju 220 - 701， Korea Extracell띠ar ATP elicits various biological responses and plays a significant role in physiological regulation. Recent1y， ATP-induced growth inhibitions were reported in some tumor cell lines， but these effects and mechanisms are not well...
289.

학생청소년의 폭력 기사에 관한 환경생태학적 연구

이길홍, 이헌재 대한신경정신의학회 신경정신의학 14 Pages

대한신경정신의학회 신경정신의학 1998, 제 37권 제 3호 5 453-466 (14 pages)

이길홍, 이헌재 저
...
- 4,300원
목 적： 일간 신문에 게재된 청소년 범죄 기사의 내용 분석을 통해 청소년 폭력을 미연에 예방 및 선도하기 위한 지침을 설정하기 위하여, 최근 11년간 동아일보 및 충청일보에 게재된 청소년 범죄 기사를 대상으로 전수 조사를 실시하였다. 방 법：자료 분석에서는 12세에서 21세에 이르는 청소년 연령층의 범죄 기사 681건(남 642건, 여 39 건)중에서 학생 범죄기사 261건(남 238건, 여 23건)을 연구 집단으로 선정하고, 비학생 범죄기사 420건 (남 404건, 여 16건)을 대조군으로 선정하여 비교 분석하였다. 결 과： 1) 학생집단은...
290.

범죄수사에 최면을 이용한 1례

박희관 대한신경정신의학회 신경정신의학 7 Pages

대한신경정신의학회 신경정신의학 1998, 제 37권 제 4호 14 745-751 (7 pages)

박희관 저
...
- 3,000원
범죄의 수사 과정에서 피해자나 목격자의 기억을 되살리고 나아가 보다 정확하게 할 목적으로 최면을 이 용한다고 한다. 이에 저자는 범죄수사에 최면을 이용한 경험을 몇 번 하였기에 그 중 1례를 문헌고찰과 함께 국내에서는 처음으로 보고하였다. 본 증례에서 최면의 이용은 차량번호의 회상이나 범인들의 검거에 결정적 인 기여를 하지는 못하였으나 향후 보다 나은 적용 및 최면과 기억 등의 연구에 대한 관심을 도모하고자 하 였다. 최면상태에서는 정확한 기억이든 부정확한 기억이든 어느 쪽도 많이 재생되고 만들어질 수 있을...

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