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371.

Increased Expression of Nitric Oxide Synthase Coincides with Reversal of Renovascular Hypertension

YunWoongPaek, Yung-hyunPark, SooWanKim, JongUnLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 9 143-147 (5 pages)

YunWoongPaek, Yung-hyunPark, SooWanKim, JongUnLee 저
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- 1,500원
The present study was aimed at investigating whether there are changes in the expression of nitric oxide synthase (NOS) in relation with the unclipping-induced fall of blood pressure in two-kidney, one clip (2K1C) hypertension. Male Sprague-Dawley rats were made 2K1C hypertensive by clipping the left renal artery for four weeks. Sham-clipped rats served as control. The expression of endothelial constitutive (ec) NOS proteins and tissue levels of NO metabolites were determined in the kidney....
372.

Glycochenodeoxycholic Acid Induces Cell Death in Primary Cultured Rat Hepatocyte Apoptosis and Necrosis

SangHuiChu, WolMiPark, KyungEunLee, YoungSookPae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 4 565-570 (6 pages)

SangHuiChu, WolMiPark, KyungEunLee, YoungSookPae 저
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- 3,000원
Intracellular accumulation of bile acids in the hepatocytes during cholestasis is thought to be pathogenic in cholestatic liver injury. Due to the detergent-like effect of the hydrophobic bile acids, hepatocellular injury has been attributed to direct membrane damage. However histological findings of cholestatic liver diseases suggest apoptosis can be a mechanism of cell death during cholestatic liver diseases instead of necrosis. To determine the pattern of hepatocellular toxicity induced by...
373.

The Enhancement of Endotoxin-Induced Nitric Oxide Production by Elevation of Glucose Concentration in Macrophage

HyunGooWoo, Yi-SookJung, EunJooBaik, Chang-HyunMoon, SooHwanLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.4 10 447-454 (8 pages)

HyunGooWoo, Yi-SookJung, EunJooBaik, Chang-HyunMoon, SooHwanLee 저
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- 3,000원
The production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS) are known to be modulated by a variety of factors. Recent study showed that endotoxin-induced NO synthesis and iNOS expression were greatly enhanced by elevation of extracellular glucose concentration in murine macrophages. Although this was suggested to be due to the activation of protein kinase C (PKC) via sorbitol pathway, there was lack of evidence for this speculation. This study was performed...
374.

Altered Renal Nitric Oxide System in Experimental Hypertensive Rats

EunSukYang, JongUnLee, DaeGillKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 7 455-460 (6 pages)

EunSukYang, JongUnLee, DaeGillKang 저
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- 3,000원
The present study was aimed at investigating whether the development of hypertension is related with an altered expression of nitric oxide synthases (NOS) in the kidney. By Western blot analysis, the expression of bNOS and ecNOS isoforms was determined in the kidney of deoxycorticosterone acetate (DOCA)-salt and two-kidney, one clip (2K1C) rats. In DOCA-salt hypertension, the expression of both bNOS and ecNOS was decreased, along with tissue contents of nitrites. In 2K1C hypertension, the...
375.

Molecular Pharmacological Interaction of Phenylbutazone to Human Neutrophil Elastase

KooilKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 14 385-393 (9 pages)

KooilKang 저
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- 3,000원
Human neutrophil elastase (HNElastase, EC 3.4.21.37), a causative factor of inflammatory diseases, was purified by Ultrogel AcA54 gel filtration and CM-Sephadex ion exchange chromatography. HNElastase was inhibited by phenylbutazone in a concentration dependent manner up to 0.4 mM, but as the concentration increased, the inhibitory effect gradually diminished. Binding of phenylbutazone to the human neutrophil elastase caused strong Raman shifts at 200, 440, and 1194 cm⁣1. The peak at 1194...
376.

Cardioprotective Effects of Low Dose Bacterial Lipopolysaccharide May Not Be Directly Associated with Prostacyclin Production

Chang-HyunMoon, JiYoungKim, SooHwanLee, EunJooBaik 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 8 331-343 (13 pages)

Chang-HyunMoon, JiYoungKim, SooHwanLee, EunJooBaik 저
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- 4,200원
by using Western blot analysis. LPS increased PGHS protein expression in hearts at 24, 48, 72, 96 h after LPS treatment. Induction of PGHS expression appeared in both isotypes of PGHS, a constitutive PGHS-1 and an inducible PGHS-2. To identify the correlationship between PGI2 production and the cardioprotective effect against I/R injury, indomethacin was administered in vivo or in vitro. Indomethacin did not inhibit LPS-induced cardioprotection, which was not affected by the duration of LPS...
377.

Inducible Nitric Oxide Synthase mRNA Expression and Nitric Oxide Production in Silica-Induced Acute Inflammatory Lung Injury

JiheeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 12 233-239 (7 pages)

JiheeLee 저
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- 3,000원
in the cells cultured. Differential analysis of broncho-alveolar lavage cells showed that the number of alveolar macrophages slightly decreased following silica treatment; however, red blood cells, lymphocytes, and neutrophils significantly were increased by 9-, 14-, and 119-fold following silica treatment, respectively, compared with the saline control. It was also found significant increases in the LDH activity and total protein in the lavage fluid obtained from silica-treated rats, indicating...
378.

기억의 뇌기전과 정신과학

이성훈 대한신경정신의학회 신경정신의학 24 Pages

대한신경정신의학회 신경정신의학 1998, 제 37권 제 1호 2 14-37 (24 pages)

이성훈 저
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- 5,300원
기억 기능은 단순한 기억 기능으로만 분리되지 않고 다른 뇌기능이 실제로 작동하는데 가장 기초적 이고 중요한 역할을 한다. 그러므로 기억 기능은 거의 대부분의 뇌기능과 관계되며 피질과 피질하의 대부분의 구조와 회로가 관여되고 있다. 그러므로 기억의 뇌기전을 이해하는 것은 기억 기능뿐만 아니 라 뇌기능과 뇌의 정보처리를 전체적으로 이해하는데 아주 중요하다. 기억은 실제로 세포간의 구조적 변화를 통해 형성된다. 어떠한 대상과 사건의 기억은 별도의 사항으로 기억되는 것이 아니라 그 사건 의 구성요소와 높은...
379.

잠재성 간성혼수 환자의 인지기능과 양성자 자기공명분광 소견과의 상관관계

김성윤, 정범석, 서동완, 이정희, 이철 대한신경정신의학회 신경정신의학 12 Pages

대한신경정신의학회 신경정신의학 1998, 제 37권 제 6호 19 1201-1212 (12 pages)

김성윤, 정범석, 서동완, 이정희, 이철 저
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- 4,100원
연구목적： 잠재성 간성혼수 환자들의 신경인지기능 장애 정도와 기저핵이나 두정엽 백질부에서의 자기공명분광 (proton MRS)으로 측정한 양성자 함유 화합물의 변화와의 상관관계를 조사하고자 하였다. 방 법： 한국판 웩슬러 지능 검사(KWIS) 중 토막짜기나 기호 바꾸기, 그리고 번호잇기 검사를 적용하여 잠재성 간성혼수로 정의된 18명의 간경변 환자를 대상군으로 하고 20명의 정상인을 대조군으로 하였다. 복합주의력 과 시각 정보 분석능력 측정을 위해 Vienna 전산화 신경인지기능 검사 중 Cognitrone 검사, 미세 협응 운동...
380.

내측 전전두피질에 6-hydroxydopamine 주입 후 흰쥐 신선조체 도파민 수용체의 변화에 관한 자가방사기록법적 연구

권준수, 이동영, 우종인 대한신경정신의학회 신경정신의학 11 Pages

대한신경정신의학회 신경정신의학 1999, 제 38권 제 2호 17 408-418 (11 pages)

권준수, 이동영, 우종인 저
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- 4,000원
전전두엽(prefrontal cortex)에서 도파민 기능의 저하가 선조체 부위의 도파민 신경계에 어떠한 변화를 초래하는지를 알기 위하여, 흰쥐 내측 전전두피질에 6-hydroxydopamine을 투여한 2주 후에 선조체 부위 인 미상핵-피각과 피질하 조직의 하나인 측좌핵에서 도파민 D1과 D2 수용체의 변화를 자가방사기록법을 이 용하여 측정하였다. 전전두엽에 6-hydroxydopamine을 투여한 2주 후 미상핵-피각과 측좌핵에서의 D1 수용체의 Bmax는 대조군과 통계적인 차이가 없었으며, Kd는 대조군에 비해 통계적으로 유의하게 감소하였다(p<0.01). 6-...

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