학지사 뉴논문

총 630건 검색

본문검색 결과만 보기

정확도순

최신순

등재순

발행기간

전체
최근 1년
최근 3년
직접입력

적용하기

본문검색

포함

제외

10개씩

421.

Lipid Peroxidation, NF-κB Activation and Cytokine Production in Neutrophil-Stimulated Pancreatic Acinar Cells

HyeyoungKim, JeongYeonSeo, SeHaengCho, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 9 521-528 (8 pages)

HyeyoungKim, JeongYeonSeo, SeHaengCho, KyungHwanKim 저
...
- 3,000원
Reactive oxygen species (ROS), generated by infiltrating neutrophils, are considered as an important regulator in the pathogenesis and deveolpment of pancreatitis. The present study aims to investigate whether neutrophils primed by 4β-phorbol 12β-myristate 13α-acetate (PMA) affect the productions H2O2 and lipid peroxide (LPO), NF-κB activation and cytokine production in pancreatic acinar cells, and whether these alterations were inhibited by an antioxidant, N-acetylcysteine (NAC) and...
422.

Effects of Cl⁣ Channel Blockers on the Cardiac ATP-sensitive K+ Channel

Yong-GeunKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 8 305-313 (9 pages)

Yong-GeunKwak 저
...
- 3,000원
To explore whether Cl⁣ channel blockers interact with the ATP-sensitive K⁢ (KATP) channel, I have examined the effect of two common Cl⁣ channel blockers on the KATP channel activity in isolated rat ventricular myocytes using patch clamp techniques. In inside-out patches, 4,4'-diisothio-cyanatostilbene- 2,2'-disulfonic acid (DIDS) and niflumic acid applied to bath solution inhibited the KATP channel activity in a concentration-dependent manner with IC50 of 0.24 and 927μM,...
423.

Aquaporins in the Kidney

SeiSasaki 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 1 271-277 (7 pages)

SeiSasaki 저
...
- 3,000원
424.

사람 Neuroblastoma SH-SY5Y 세포주에서 Opiate 내성에 의한 c-myc 유전자 표현 The c-myc Expression on the Opioid Tolerance in Human Neuroblastoma SH-SY5Y Cells

김수경, 박창교, 권지윤, 서성일, Soo-kyungKim, Chang-kyoPark, Gee-younKwon, Sung-ilSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 10 691-697 (7 pages)

김수경, 박창교, 권지윤, 서성일, Soo-kyungKim, Chang-kyoPark, Gee-younKwon, Sung-ilSuh 저
...
- 3,000원
The mechanisms underlying opiate tolerance and dependence are not fully understood. We used human neuroblastoma SH-SY5Y cells as a model system for studying effects of morphine tolerance and withdrawal on c-myc induction and cAMP levels. It has been reported that regulation of c-fos by acute and chronic morphine withdrawal is mediated through alterations in CREB transcription factor. In this study, we examined the effects of morphine tolerance on c-myc expression and cAMP concentrations. The...
425.

Distributional Patterns of Phospholipase C Isozymes in Heart and Brain of Spontaneously Hypertensive and Normotensive Rats

Ji-WoongChoi, Young-JinCho, SeokHoCha, Kweon-HaengLee, Sang-BokLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 5 385-392 (8 pages)

Ji-WoongChoi, Young-JinCho, SeokHoCha, Kweon-HaengLee, Sang-BokLee 저
...
- 3,000원
The phospholipase C (PLC)-mediated intracellular signal transduction pathway is considered to be involved in the regulation of blood pressure. However, little information is available concerning the distributional and functional significance of PLC in the genetic hypertensive rats. As the first step of knowing the role of PLC on hypertension, we investigated the distribution of 6 PLC isozymes (PLC-β1, -β3, -β4, -γ1, -γ2 and -δ1) in the heart and brain, which are concerned with...
426.

Cloning of Mouse AQP-CD Gene

JinSupJung, JooInKim, SaeOkOh, MiYoungPark, HaeRhanBae, SangHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 9 195-200 (6 pages)

JinSupJung, JooInKim, SaeOkOh, MiYoungPark, HaeRhanBae, SangHoLee 저
...
- 3,000원
Water transport in highly-permeable membranes is facilitated by some specialized pathways, which are called aquaporins (AQP). AQP1 (AQP-CHIP) is the first recognized aquaporin identified from red cells and renal proximal tubules. Up until now 4 other aquaporin homologs have been reported. Each aquaporin has its unique tissue distribution and regulatory mechanims. To elucidate molecular mechanisms for their transcription regulation and tissue-specific expression isolation of aquaporin genes is...
427.

Functional Characteristics of Neutral Amino Acid Transporter in Opossum Kidney (OK) Cells

JaeSukWoo, MoonHwanPark, SaeOkOh, JinSupJung, YongKeunKim, SangHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 8 185-193 (9 pages)

JaeSukWoo, MoonHwanPark, SaeOkOh, JinSupJung, YongKeunKim, SangHoLee 저
...
- 3,000원
of Na+-dependent cycloleucine uptake was investigated in OK cells with regard to substrate specificity and regulation by protein kinase C (PKC). Inhibition studies with different synthetic and natural amino acids showed a broad spectrum affinity to neutral amino acids regardless of their different side chains including branched or aromatic, indicating that the Na+-dependent cycloleucine uptake in OK cells is mediated by System Bo or System Bo-like transporter rather than the classical System A...
428.

Enhanced Coupling of M1 Muscarinic Receptors to Activation of Phospholipase C upon Mutation of a Transposed Amino Acid Triplet Repeat

Seok-YongLee, Ki-WugSung, Ok-NyuKim, Sang-BokLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 3 19-25 (7 pages)

Seok-YongLee, Ki-WugSung, Ok-NyuKim, Sang-BokLee 저
...
- 3,000원
at the interface between the second transmembrane domain and the first extracellular loop. Interestingly, however, it is repeated in a transposed fashion (LYT-LYT) in the sequence of M2 receptors. In our previous work, we investigated the possible significance of this unique sequence diversity for determining the distinct differential receptor function at the two receptor subtypes. However, we found mutation of the LYTTYL sequence of M1 receptors to the corresponding M2 receptor LYTLYT sequence...
429.

항우울제 장기 투여에 의한 흰쥐 해마에서 PhosphoCREB의 발현 증가

김소양, 한진희, 이창욱, 백인호 대한신경정신의학회 신경정신의학 7 Pages

대한신경정신의학회 신경정신의학 1998, 제 37권 제 5호 22 992-998 (7 pages)

김소양, 한진희, 이창욱, 백인호 저
...
- 3,000원
목 적： 저자들은 paroxetine(selective serotonin reuptake inhibitor), desipramine(selective norepinephrine reuptake inhibitor), moclobemide(reversible monoamine oxidase inhibitor)의 항우울제를 흰쥐에 장기 투여한 후 해마에서 phosphoCREB의 발현정도를 측정하고 이를 항정신병약물, 항불안제 및 control을 장기 투여하였을 때의 발현정도와 비교해 보고자 하였다. 방 법： 실험동물로는 체중 200∼300g의 Sprague-Dawley 수컷 흰쥐 240마리를 사용하였고, paroxetine 투여군, desipramine 투여군, moclobemide 투여군,...
430.

백서 뇌 별아교세포에서 LipopolysaccharideI에 의한 Nitric Oxide 생성기전

소광, 박래길, 이상렬, 박민철 대한신경정신의학회 신경정신의학 13 Pages

대한신경정신의학회 신경정신의학 1999, 제 38권 제 4호 20 881-893 (13 pages)

소광, 박래길, 이상렬, 박민철 저
...
- 4,200원
연구목적： Nitric oxide(NO)는 뇌졸중 및 여러 가지 신경변성 질환의 병리생리에 중요한 역할을 한다. 본 연구는 백서 뇌로부터 분리한 별아교세포에서 세균내독소 lipopolysaccharide(LPS)에 의한 NO 생성과정이 MAP kinase cascades와 전사 활성인자 NF-kB에 의해 중재됨을 밝히고자 하는 것이다. 방 법： NO 생성은 Greese’s reagents와 Western blot analysis를 사용하여 측정하였고 Erk, JNK1, p38은 in vitro immunecomplex kinase assay로 측정했다. NF-kB의 전사적 활성은 electrophoretic mobility shift assay로 결정하였다....

한주간 이슈검색어