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51.

A Simple Dosing Scheme for Intravenous Busulfan Based on Retrospective Population Pharmacokinetic Analysis in Korean Patients

SangminChoe, GayeongKim, Hyeong-SeokLim, Sang-HeonCho, Jong-LyulGhim, JinAhJung, Un-JibKim, GyujeongNoh, Kyun-SeopBae, DonghoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 7 273-280 (8 pages)

SangminChoe, GayeongKim, Hyeong-SeokLim, Sang-HeonCho, Jong-LyulGhim, JinAhJung, Un-JibKim, GyujeongNoh, Kyun-SeopBae, DonghoLee 저
...
- 3,000원
Busulfan is an antineoplastic agent with a narrow therapeutic window. A post-hoc population pharmacokinetic analysis of a prospective randomized trial for comparison of four-times daily versus once-daily intravenous busulfan was carried out to search for predictive factors of intravenous busulfan (iBu) pharmacokinetics (PK). In this study the population PK of iBu was characterized to provide suitable dosing recommendations. Patients were randomized to receive iBu, either as 0.8 mg/kg every 6 h...
52.

Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats

MajidAsiabanha, GholamrezaAsadikaram, AmirRahnema, MehdiMahmoodi, GholamhoseinHasanshahi, MohammadHashemi6, MohammadKhaksari 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 2 327-332 (6 pages)

MajidAsiabanha, GholamrezaAsadikaram, AmirRahnema, MehdiMahmoodi, GholamhoseinHasanshahi, MohammadHashemi6, MohammadKhaksari 저
...
- 3,000원
It has been shown that some opium derivatives promote cell death via apoptosis. This study was designed to examine the influence of opium addiction on brain and liver cells apoptosis in male and female diabetic and non-diabetic Wistar rats. This experimental study was performed on normal, opium-addicted, diabetic and diabetic opium-addicted male and female rats. Apoptosis was evaluated by TUNEL and DNA fragmentation assays. Results of this study showed that apoptosis in opium-addicted and...
53.

Testosterone Relaxes Rabbit Seminal Vesicle by Calcium Channel Inhibition

JongKokKim, WooHaHan, MooYeolLee, SoonChulMyung, SaeChulKim, MinKyKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.2 6 73-78 (6 pages)

JongKokKim, WooHaHan, MooYeolLee, SoonChulMyung, SaeChulKim, MinKyKim 저
...
- 3,000원
(0.1ՌM), 4-aminopyridine (4-AP, 10ՌM), or glibenclamide (10ՌM) rarely affected these relaxations. Single channel data (of inside-out and attached configurations) of BK channel activity were also hardly affected by testosterone (10ՌM). On the other hand, however, testosterone reduced L-type Ca2+ currents significantly, and found to induce acute relaxation of seminal vesicular smooth muscle and this was mediated, at least in part, by Ca2+ current inhibition in rabbit.
54.

Increased Rate of Palmitate Oxidation in Adults Female: Comparison with Peri-pubertal Young Female Rats

SeYoungLee, Jong-YeonKim, Yong-WoonKim, So-YoungPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 9 283-288 (6 pages)

SeYoungLee, Jong-YeonKim, Yong-WoonKim, So-YoungPark 저
...
- 3,000원
Although estrogen is known to play a role in fatty acid metabolism, it remains unclear whether fatty acid oxidation in mature female rats differs from fatty acid oxidation in peri-pubertal young rats. In this study, we measured fatty acid metabolism in the skeletal muscles and livers of 5 and 50 weeks old male and female rats. The rate of palmitate oxidation in the liver and gastrocnemius red in the 50-week-old female rats were elevated as compared to the 5-week-old females, whereas there were...
55.

Acute Effect of Alcohol and Nicotine on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal and Median Raphe of Rats

Mi-HyeonJang, Min-ChulShin, Hyun-KyungChang, Taeck-HyunLee, Khae-HawnKim, Youn-JungKim, Chang-JuKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 2 5-8 (4 pages)

Mi-HyeonJang, Min-ChulShin, Hyun-KyungChang, Taeck-HyunLee, Khae-HawnKim, Youn-JungKim, Chang-JuKim 저
...
- 1,500원
Alcohol abuse and cigarette smoking have been on the rise worldwide and it has been reported that alcohol and nicotine influence serotonergic neuronal activity in the dorsal raphe. Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders. In the present study, the effects of alcohol and nicotine on the synthesis of 5-HT and the expression of tryptophan hydroxylase (TPH), the rate limiting enzyme of 5-HT synthesis, in the dorsal and...
56.

Effect of Serotonin Uptake Inhibitors on Serotonin Metabolism in the Hypothalamus of Freely Moving Rats

YunSeobSong, SeNaYoon, DongSikJung, SangHeeYoo, HyongKyunRyu, HyungGunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 1 427-437 (11 pages)

YunSeobSong, SeNaYoon, DongSikJung, SangHeeYoo, HyongKyunRyu, HyungGunKim 저
...
- 4,000원
MPOA was clomipramine, sertraline, paroxetine and fluoxetine and the concentrations of 5-HIAA was vice versa. The changes in serotonin concentration at the MPOA appeared closely associated with the clinical effects of these drugs on premature ejaculation. These results suggest that the serotonergic neuronal activity in the MPOA may have an selective inhibitory influence on ejaculation, and the effects of clomipramine and SSRIs on erectile function are mainly mediated by MPOA of the hypothalamus.
57.

Hemorrhage- and Restraint-induced Analgesia in Male and Female Conscious Rats

SungYunOh, HeeSeokHan, DongKukAhn, JaeSikPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 3 555-563 (9 pages)

SungYunOh, HeeSeokHan, DongKukAhn, JaeSikPark 저
...
- 3,000원
It is well known that stress induces analgesia. This study was designed to demonstrate the stress-induced analgesia by employing hemorrhage and restraint and to investigate its mechanism and sex difference. The degree of pain was assessed by measuring the magnitude of jaw opening reflex produced by a noxious electrical stimulation in the dental pulp and by measuring the latency to withdraw the tail from a heat ray. Restraint showed an antinociceptive response. A significant increase in pain...
58.

酒精依存에서 血漿 Dopamine 및 Serotonin 濃度變化의 意味

田珍淑, 金玹壽, 吳秉勳 대한신경정신의학회 신경정신의학 13 Pages

대한신경정신의학회 신경정신의학 1997, 제 36권 제 3호 15 547-559 (13 pages)

田珍淑, 金玹壽, 吳秉勳 저
...
- 4,200원
59.

알코올 의존 환자에서의 혈청 성호르몬, 성선자극호르몬, 코티졸 및 프로락틴

서동수, 박두병, 이길홍 대한신경정신의학회 신경정신의학 10 Pages

대한신경정신의학회 신경정신의학 1998, 제 37권 제 3호 12 527-536 (10 pages)

서동수, 박두병, 이길홍 저
...
- 3,000원
연구목적： 알코올 의존 환자들에서 흔히 보이는 성기능장애는 신경병적 요인과 사회심리학적 요인을 배제할 수는 없지 만 내분비 기능의 이상에 의해 기인하는 것으로 알려져왔다. 이러한 내분비 이상을 밝히는 예비적 단계로써 알 코올 의존 환자에서 성호르몬, 성선 자극 호르몬, 코티졸과 프로락틴을 살펴보고자 본 연구를 시행하였다. 방 법： 알코올 의존을 가진 15명의 환자군에서 금단중과 금주후 21일후에 시상하부-뇌하수체-성선축 호르몬 (테스토스테론, 에스트라디올, 황체화 호르몬, 난포자극 호르몬)을 검사하였으며 이축에...
60.

정신분열증 환자에서 주관적 음성증상경험의 임상적 의의

김지웅, 김찬형, 구민성, 손석한, 박진철, 최문종, 이은철, 윤도준, 이홍식 대한신경정신의학회 신경정신의학 11 Pages

대한신경정신의학회 신경정신의학 1999, 제 38권 제 1호 10 128-138 (11 pages)

김지웅, 김찬형, 구민성, 손석한, 박진철, 최문종, 이은철, 윤도준, 이홍식 저
...
- 4,000원
연구목적： 현재까지 정신분열증의 음성증상평가는 주로 객관적인 평가에만 의존해왔기 때문에, 환자들이 주관적으로 직 접 경험하는 음성증상의 평가는 경시된 경향이 있었다. 그러나 실제 많은 정신분열증 환자들은 음성증상을 자각 하고 있다. 특히, 객관적인 양성 및 음성증상이 관찰되지 않는 경우에도 환자 본인은 음성증상으로 괴로워한 다는 이전의 연구보고들이 있었다. 따라서, 저자들은 주관적인 음성증상경험과 객관적인 양성증상 및 음성증상, 우울증상, 불안증상, 추체외로증상과의 상관성을 알아봄으로써 정신분열증의...

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