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본문검색 결과만 보기
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Alterations of Amino Acid Level in Depressed Rat Brain
PeiYang*, XuechunLi*, JianNi, JingchenTian, FuJing, ChanghaiQu, LongfeiLin, HuiZhang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.5 3 371-376 (6 pages)
Amino-acid neurotransmitter system dysfunction plays a major role in the pathophysiology of depression. Several studies have demonstrated the potential of amino acids as a source of neuro-specific biomarkers could be used in future diagnosis of depression. Only partial amino acids such as glycine and asparagine were determined from certain parts of rats’ brain included hippocampi and cerebral cortex in previous studies. However, according to systematic biology, amino acids in different area of... -
Effects of Watercress Containing Rutin and Rutin Alone on the Proliferation and Osteogenic Differentiation of Human Osteoblast-like MG-63 Cells
HanbitHyun, HeajinPark, JaehoonJeong, JihyeKim, HaesungKim, HyunIlOh, HyeSeongHwang, HaHyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.4 10 347-352 (6 pages)
Most known osteoporosis medicines are effective for bone resorption, and so there is an increasing demand for medicines that stimulate bone formation. Watercress (N. officinale R. Br.) is widely used as a salad green and herbal remedy. This study analyzed a watercress extract using ultra-performance liquid chromatography/mass spectrometry, and identified a rutin as one of its major constituents. Osteogenic-related assays were used to compare the effects of watercress containing rutin (WCR) and... -
Gecko Proteins Exert Anti-Tumor Effect against Cervical Cancer Cells Via PI3-Kinase/Akt Pathway
Ae-JinJeong, Chung-NamChung, Hye-JinKim, KilSooBae, SongChoi, WooJinJun, SangInShim, Tae-HongKang, Sun-HeeLeem, JinWoongChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 12 361-365 (5 pages)
Anti-tumor activity of the proteins from Gecko (GP) on cervical cancer cells, and its signaling mechanisms were assessed by viable cell counting, propidium iodide (PI) staining, and Western blot analysis. GP induced the cell death of HeLa cells in a dose-dependent manner while it did not affect the viability of normal cells. Western blot analysis showed that GP decreased the activation of Akt, and co-administration of GP and Akt inhibitors synergistically exerted anti-tumor activities on HeLa... -
Modern Methods for Analysis of Antiepileptic Drugs in the Biological Fluids for Pharmacokinetics, Bioequivalence and Therapeutic Drug Monitoring
JuseopKang, Yoo-SinPark, Shin-HeeKim, Sang-HyunKim, Min-YoungJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 1 67-82 (16 pages)
Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 30% of the epileptic patients treated with availably antiepileptic drugs (AEDs) continue to have seizures and are considered therapy-resistant or refractory patients. The ultimate goal for the use of AEDs is complete cessation of seizures without side effects. Because of a narrow therapeutic index of AEDs, a complete understanding of its clinical pharmacokinetics is essential for understanding of the... -
Regional Differences in Mitochondrial Anti-oxidant State during Ischemic Preconditioning in Rat Heart
VuThiThu, DangVanCuong, NariKim, JaeBoumYoum, MohamadWarda, WonSunPark, JaeHongKo, EuiyongKim, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.2 3 57-64 (8 pages)
Ischemic preconditioning (IPC) is known to protect the heart against ischemia/reperfusion (IR)-induced injuries, and regional differences in the mitochondrial antioxidant state during IR or IPC may promote the death or survival of viable and infarcted cardiac tissues under oxidative stress. To date, however, the interplay between the mitochondrial antioxidant enzyme system and the level of reactive oxygen species (ROS) in the body has not yet been resolved. In the present study, we examined the... -
Increased Expression of Nitric Oxide Synthases in Left and Right Ventricular Hypertrophy
JongUnLee, YoonWhaOh, SunmiKim, DaeGillKang, WonJungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 9 65-70 (6 pages)
The present study was aimed to explore pathophysiological implications of nitric oxide in the development of left and right ventricular hypertrophy. To induce selective left and right ventricular hypertrophy, rats were made two-kidney, one clip (2K1C) hypertensive and treated with monocrotaline (MCT), respectively. Six weeks later, the hearts were taken and their ventricular tissue mRNA and protein expression of endothelial constitutive isoform of nitric oxide synthase (NOS) were determined by... -
애착장애 아동에서 99m-Tc-ECD-SPECT로 측정한 뇌혈류량의 양상
천근아, 이경숙, 신의진 대한신경정신의학회 신경정신의학 11 Pages
대한신경정신의학회 신경정신의학 2001, 제 40권 제 1호 10 98-108 (11 pages)
연구목적： 아동 학대 또는 방치와 같은 병적인 양육환경이 신경생물학적인 변화를 야기할 수 있다는 가정 하에, 심각 한 주양육자와의 애착관계의 문제를 보이는 아동들을 대상으로 SPECT를 이용한 뇌 혈류 양상을 알아보고 뇌의 비정상 소견 여부를 관찰하고자 한다. 방 법： 연구대상은 반응성애착장애(reactive attachment disorder)로 진단된 2∼6세 아동 12명으로 구성되었다. 진단도구로서 DSM-IV, ICD-10, 낯선상황절차(Strange Situation Procedure), 사회성숙도 검사(Social Maturity Scale), 아동기 자폐증 평가척도(Childhood... -
정신분석의 역사-분석이론의 진화를 중심으로
대한신경정신의학회 신경정신의학 2010, 제 49권 제 1호 5 9-35 (27 pages)
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당뇨병성 신증의 발생에 있어서 산화성 스트레스의 역할
장연진(Yeon Jin Jang), 박형섭(Hyoung-sup Park), 김현식(Hyoun Sik Kim), 홍혜남(Hea Nam Hong), 김미경(Mi Kyung Kim) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1995, 제 31권 제 1호 10 95-102 (8 pages)
고혈당증, 단백뇨, 고혈압의 증상을 보였으며 신장조직은 보상성 비대와 함께 혈관간기질(mesangial matrix) 증대의 형태학적 변화를 보였다. 그러나 스트렙토조토신만을 주사한 쥐(STZ)에서는 단백뇨가 나타나지 않았고, 신장적출만을 한 쥐에서는(NEPH) 단백뇨의 증상은 나타났으나 신장조직의 형태학적 관찰에서 혈관간 기질의 증대는 보이지 않았다. 이화같이 그 증상이나 신장조직 병변의 정도는 모두 달랐음에도 불구하고, 신피질 조직 단백질의 산화는 NEPH, STZ, NEPH-STZ의 세 실험군 쥐에서 대조군(CONT)에 비해 유의하게 증가 ... -
Effect of Ischemic Preconditioning on the Oxygen Free Radical Production in the Post-ischemic Reperfused Heart
박종완(Jong-Wan Park), 김영훈(Young-Hoon Kim), 엄창섭(Chang-Sub Uhm), 배재문(Jae-Moon Bae), 박찬웅(Chan-Woong Park), 김명석(Myung-Suk Kim) 대한약리학회 대한약리학잡지 10 Pages
대한약리학회 대한약리학잡지 1994, 제 30권 제 3호 6 321-330 (10 pages)
The protective effect of ischemic preconditioning (PC) on ischemia-reperfusion injury of heart has been reported in various animal species, but without known mechanisms in detail. In an attempt to investigate the cardioprotective mechanism of PC, we examined the effects of PC on the myocardial oxidative injuries and the oxygen free radical production in the ischemia-reperfusion model of isolated Langendorff preparations of rat hearts. PC was performed with three episodes of 5 min ischemia and...
