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전체 선택해제
총 214건 검색
본문검색 결과만 보기
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Temporal Changes in Neuronal Activity of the Bilateral Medial Vestibular Nuclei Following Unilateral Labyrinthectomy in Rats
ByungRimPark, MoonYoungLee, MinSunKim, SungHoLee, HanJoNa, NamYongDoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 4 481-490 (10 pages)
To investigate the changes in the responses of vestibular neurons with time during vestibular compensation, the resting activity and dynamic responses of type I and II neurons in the medial vestibular nuclei to sinusoidal angular acceleration were recorded following unilateral labyrinthectomy (ULX) in Sprague-Dawley rats. The unitary extracellular neuronal activity was recorded from the bilateral medial vestibular nuclei with stainless steel microelectrodes of 3∼5 MΩ before ULX, and 6, 24,... -
Physiological and Pharmacological Characterization of Glutamate and GABA Receptors in the Retina
Xiong-LiYang, YingShen, Ming-HuHan, TaoLu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 2 461-469 (9 pages)
subtype, which predominantly consists of flop splice variants. GABAA and GABAC receptors coexist in bipolar cells and they both show significant desensitization. Kinetics analysis demonstrated that activation, deactivation and desensitization of the GABAC receptor-mediated response of these cells are overall slower than those of the GABAA response. Endogenous modulator Zn2 in the retina was found to differentially modulate the kinetic characteristics of the GABAC and GABAA responses. -
Effects of Cl Channel Blockers on the Cardiac ATP-sensitive K+ Channel
Yong-GeunKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 8 305-313 (9 pages)
To explore whether Cl channel blockers interact with the ATP-sensitive K (KATP) channel, I have examined the effect of two common Cl channel blockers on the KATP channel activity in isolated rat ventricular myocytes using patch clamp techniques. In inside-out patches, 4,4'-diisothio-cyanatostilbene- 2,2'-disulfonic acid (DIDS) and niflumic acid applied to bath solution inhibited the KATP channel activity in a concentration-dependent manner with IC50 of 0.24 and 927μM,... -
Effects of Ethanol on Na+-dependent Solute Uptake in Rabbit Renal Brush-Border Membrane Vesicles
YongKeunKim, SunHeeKo, JaeSukWoo, JinSupJung, SangHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 9 191-198 (8 pages)
The H/TEA antiport was reduced by 8% ethanol. Kinetic analysis showed that ethanol caused a decrease in Vmax of three transport systems, leaving Km values unchanged. Ethanol decreased phlorizin binding, which was closely correlated with the decrease in Vmax of Na-glucose uptake. These results indicate that ethanol inhibits Na-dependent uptakes of glucose, phosphate, and dicaboxylate and that the reduction in Vmax of Na-glucose uptake is caused by a decrease in the... -
The Role of Intracellular Mg2+ in Regulation of Ca2+-activated K+ Channel in Pulmonary Arterial Smooth Muscle Cells of the Rabbit
SukHoLeeMyoungKyuPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 9 611-616 (6 pages)
Although the Ca2+-activated K+ (IK,Ca) channel is known to play an important role in the maintenance of resting membrane potential, the regulation of the channel in physiological condition is not completely understood in vascular myocytes. In this study, we investigated the role of cytoplasmic Mg2+ on the regulation of IK,Ca channel in pulmonary arterial myocytes of the rabbit using the inside-out patch clamp technique. Mg2+ increased open probability (Po), but decreased the magnitude of single... -
Increased Activity of Large Conductance Ca2+-Activated K+ Channels in Negatively-Charged Lipid Membranes
JinBongParkPanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 15 529-539 (11 pages)
The effects of membrane surface charge originated from lipid head groups on ion channels were tested by analyzing the activity of single large conductance Ca2-activated K (maxi K) channel from rat skeletal muscle. The conductances and open-state probability (Po) of single maxi K channels were compared in three types of planar lipid bilayers formed from a neutral phosphatidylethanolamine (PE) or two negatively-charged phospholipids, phosphatidylserine (PS) and phosphatidylinositol... -
Functional Characteristics of Neutral Amino Acid Transporter in Opossum Kidney (OK) Cells
JaeSukWoo, MoonHwanPark, SaeOkOh, JinSupJung, YongKeunKim, SangHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 8 185-193 (9 pages)
The characteristics of Na+-dependent cycloleucine uptake was investigated in OK cells with regard to substrate specificity and regulation by protein kinase C (PKC). Inhibition studies with different synthetic and natural amino acids showed a broad spectrum affinity to neutral amino acids regardless of their different side chains including branched or aromatic, indicating that the Na+-dependent cycloleucine uptake in OK cells is mediated by System Bo or System Bo-like transporter rather than the... -
Two Types of Voltage-dependent Outward Potassium Currents in Smooth Muscle Cells of Rabbit Basilar Atery
TongMookKang, InsukSo, DaeYongUhm, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 15 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 7 169-183 (15 pages)
We have investigated the two types of voltage-dependent outward potassium (K) currents, i.e. delayed rectifier K current (IK(V)) and 'A-like' transient outward K current (Ito) with patch-clamp technique in single smooth muscle cells (SMCs) isolated from rabbit basilar artery, and investigated the characteristics of them. The time-courses of activation were well fitted by exponential function raised to second power (n2) in IK(v) and fourth power (n4) in Ito. The activation, inactivation and...
