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81.

CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1α in Hepatoma Cells

Kyoung-HwaLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 13 331-336 (6 pages)

Kyoung-HwaLee 저
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- 3,000원
In rapidly growing tumors, hypoxia commonly develops due to the imbalance between O2 con</SUB>sumption and supply. Hypoxia Inducible Factor (HIF)-1Ձ is a transcription factor responsible for tumor growth and angiogenesis in the hypoxic microenvironment; thus, its inhibition is regarded as a promising strategy for cancer therapy. Given that CamKII or PARP inhibitors are emerging anticancer agents, we investigated if they have the potential to be developed as new HIF-1Ձ-targeting...
82.

Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130/ STAT3 Signaling

HyunKyoungLee, InAeSeo, SangHwaLee, Su-YoungSeo, KyungSupKim, HwanTaePark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.5 10 281-285 (5 pages)

HyunKyoungLee, InAeSeo, SangHwaLee, Su-YoungSeo, KyungSupKim, HwanTaePark 저
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- 1,500원
Although the interaction between gp130 and the ErbB family has frequently been shown in cancer cells, the mechanism of this interaction remains unclear and controversial. In the present study, we found that specific tyrphostin inhibitors of ErbB2 (AG825 and AG879), but not ErbB1 inhibitor (AG1478), suppressed IL-6-induced tyrosine phosphorylation of STAT3 in schwannoma cells. However, biochemical evidence for transactivation of ErbB2 by IL-6 was not observed. Additionally, the inhibition of...
83.

Differential Activation of Ras/Raf/MAPK Pathway between Heart and Cerebral Artery in Isoproterenol-induced Cardiac Hypertrophy

HyunjuKim, NariKim, HyunJoo, JaeBoumYoum, WonSunPark, MohamedWarda, SunghyunKang, VuThiThu, TranMinhKhoa, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 7 299-304 (6 pages)

HyunjuKim, NariKim, HyunJoo, JaeBoumYoum, WonSunPark, MohamedWarda, SunghyunKang, VuThiThu, TranMinhKhoa, JinHan 저
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- 3,000원
Cardiac hypertrophy contributes an increased risk to major cerebrovascular events. However, the molecular mechanisms underlying cerebrovascular dysfunction during cardiac hypertrophy have not yet been characterized. In the present study, we examined the molecular mechanism of isoproterenol (ISO)-evoked activation of Ras/Raf/MAPK pathways as well as PKA activity in cerebral artery of rabbits, and we also studied whether the activations of these signaling pathways were altered in cerebral artery,...
84.

ATP-sensitive K+ Channels Structure, Function, and Physiological Roles

SusumuSeino 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.4 1 271-274 (4 pages)

SusumuSeino 저
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- 1,500원
85.

成長期의 家族環境 및 生物遺傳的性格-氣質的特性이 孝의 情緖的, 行動的特性에 미치는 影響

류인균, 홍강의, 조두영 대한신경정신의학회 신경정신의학 11 Pages

대한신경정신의학회 신경정신의학 1998, 제 37권 제 5호 15 921-931 (11 pages)

류인균, 홍강의, 조두영 저
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- 4,000원
연구목적： 본 연구의 목적은 成長期의 家族環境과 先天的인 氣質 및 性格特性이 行動的孝認識과 情緖的孝認識의 形成에 미치는 特定한 選擇的影響을 分析하는 것이다. 방 법：多段階群集分析方法으로 선정된 서울지역 男女大學生 132명을 대상으로 Structured Clinical Interview for DSM-III-R과 Personality Disorder Questionnaire-Revised를 사용하여 共存 Axis I 및 Axis II 精神科障碍有無를 검사하였다. 共存精神科障碍 및 기타 배제요건을 가진 34명을 제외한 서울지역 대학생 (男子 49명, 女子 49명)과 그 父母가...
86.

조직시민행동에 대한 근로몰입 유형간의 구조 분석 - 사회복지직 공무원을 대상으로

강종수 한국복지행정학회 복지행정논총 24 Pages

한국복지행정학회 복지행정논총 2010, 제 20권 제 1호 1 1-24 (24 pages)

강종수 저
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- 5,300원
본 연구는 사회복지직 공무원의 자발적인 업무외 행동인 조직시민행동에 대한 근로몰입의 네 가지 유형, 즉 직무몰입, 조직몰입, 경력몰입 그리고 관계몰입간 의 관계와 효과를 구조분석한 것으로, 표집은 사회복지직 공무원 444명을 대상 으로 구조화된 설문조사를 실시하였다. 연구결과 근로몰입 수준은 비교적 평균 보다 높게 나타났고, 인구사회적 특성에 따라 다소 차이가 있으며, 근로몰입 유 형간에는 직무몰입이 경력몰입과 관계몰입 그리고 조직몰입에 영향을 미치고, 경력몰입은 관계몰입에 그리고 관계몰입은 조직몰입에...
87.

Ser360 and Ser364 in the Kinase Domain of Tomato SlMAPKKKα are Critical for Programmed Cell Death Associated with Plant Immunity

한국식물병리학회 The Plant Pathology Journal 7 Pages

한국식물병리학회 The Plant Pathology Journal 2017, 33권 2호 8 163-169 (7 pages)

저
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- 3,000원
SlMAPKKKα, a tomato (Solanum lycopersicum) mitogen-activated protein kinase kinase kinase, is a positive regulator of Pto-mediated effector-triggered immunity, which elicits programmed cell death (PCD) in plants. In this study, we examined whether putative phosphorylation sites in the conserved activation segment of the SlMAPKKKα kinase domain are critical for eliciting PCD. Three amino acids, threonine353, serine360 (Ser360), or serine364 (Ser364), in the conserved activation...
88.

The Road to RNA Silencing is Paved with Plant-Virus Interactions

한국식물병리학회 The Plant Pathology Journal 10 Pages

한국식물병리학회 The Plant Pathology Journal 2011, 27권 3호 1 197-206 (10 pages)

저
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- 3,000원
RNA silencing has had a large impact on biology in general, as well as on our understanding of plantpathogen interactions, especially interactions between plants and viruses. While most of what we know about the mechanism of RNA silencing was deduced in the last 12 years, many of the interactions between plants and viruses, as well as virus-virus interactions in plants, which we now know are manifestations of RNA silencing, were the subject of decades of work from numerous laboratories. These...
89.

Suppression of UDP-glycosyltransferase-coding Arabidopsis thaliana UGT74E2 Gene Expression Leads to Increased Resistance to Psuedomonas syringae pv. tomato DC3000 Infection

한국식물병리학회 The Plant Pathology Journal 13 Pages

한국식물병리학회 The Plant Pathology Journal 2011, 27권 2호 10 170-182 (13 pages)

저
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- 4,200원
Plants possess multiple resistance mechanisms that protect themselves against pathogen attack. To identify unknown components of the defense machinery in Arabidopsis, gene-expression changes were monitored in Arabidopsis thaliana under 18 different biotic or abiotic conditions using a DNA microarray representing approximately 25% of all Arabidopsis thaliana genes (www.genevestigator.com). Seventeen genes which are early responsive to salicylic acid (SA) treatment as well as pathogen infection...
90.

Regulation of Pathogenesis by Light in Cercospora zeae-maydis: An Updated Perspective

한국식물병리학회 The Plant Pathology Journal 7 Pages

한국식물병리학회 The Plant Pathology Journal 2011, 27권 2호 1 103-109 (7 pages)

저
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- 3,000원
The fungal genus Cercospora is one of the most ubiquitous groups of plant pathogenic fungi, and gray leaf spot caused by C. zeae-maydis is one of the most widespread and damaging foliar diseases of maize in the world. While light has been implicated as a critical environmental regulator of pathogenesis in C. zeae-maydis, the relationship between light and the development of disease is not fully understood. Recent discoveries have provided new insights into how light influences pathogenesis and...

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