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전체 선택해제
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신생아에서 Recombinant Hepatitis B Virus Vaccine(HG-II)의 면역원성 및 안전성 확인을 위한 제 III상 임상시험
조윤경, 정양숙, 이계우, 김윤옥, 최명범, 신선경, 박찬후, 우향옥, 맹국영, 윤희상, Cho. Yun-Kyong, Jung. Yang-Suk, Yi. Gye-Woo, Kim. Yoon-Ok, Choi. Myoung-Bum, Shin. Sun-Kyung, 대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 9 Pages
대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 1996, Vol.4 No.2 197-205 (9 pages)
개발되어 이용되고 있다. 기존의 Saccharomyces cerevisiae를 이용하여 생산되는 유전자 재조합 B형 간염백신의 단점인 낮은 생산성과 불안정한 plasmid stability를 개선하여 3-4배정도 생산성을 향상시키고 hyperglycosylation을 극복한 Hansenula polymorpha 유래 2세대 간염백신인 헤파박스-진은 이미 동물실험을 통하여 면역원성 및 안전성에 대한 검증이 이루어졌다. 이에 본연구는 침판지에서의 전 임상시험 결과 $20;{mu}g$의 HBsAg 투여시 감염방어 효과가 증명된 HC-II B형 간염백신을 성인용량의 반인 0.5 ml $(10;{mu}g)$을... -
리포솜을 이용한 플라스미드 DNA의 봉입
송미향, 이만형, 용철순, 오두만, Song. Mi-Hyang, Lee. Mann-Hyung, Yong. Chul-Soon, Oh. Doo-Man 한국약제학회 藥劑學會誌 7 Pages
한국약제학회 藥劑學會誌 1996, Vol.26 No.4 291-297 (7 pages)
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유산균의 Host-Vector System 개발
윤성식, 김창민 한국미생물생명공학회 산업미생물학회지 11 Pages
한국미생물생명공학회 산업미생물학회지 2001, Vol.29 No.1 1-11 (11 pages)
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Transformation of Leuconostoc mesenteroides SY1, a Strain Isolated from Kimchi
JEONG. SEON-JU, PARK. JAE-YONG, KIM. JONG HWAN, KIM. GYEONG MIN, CHUN. JIYEON, LEE. JONG-HOON, CHUNG. DAE-KYUN, KIM. JEONG HWAN 한국미생물생명공학회 Journal of microbiology and biotechnology 4 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2006, Vol.16 No.1 149-152 (4 pages)
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Cloning, expression and functional analysis of the duck Toll-like receptor 5 (TLR5) gene
Yuqiang Cheng, Yingjie Sun, Hengan Wang, Shuduan Shi, Yaxian Yan, Jing Li, Chan Ding, Jianhe Sun 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 6 37-46 (10 pages)
Toll-like receptor 5 (TLR5) is responsible for the recognition of bacterial flagellin in vertebrates. In the present study, the first TLR5 gene in duck was cloned. The open reading frame (ORF) of duck TLR5 (dTLR5) cDNA is 2580 bp and encodes a polypeptide of 859 amino acids. We also cloned partial sequences of myeloid differentiation factor 88, 2’-5’-oligoadenylate synthetase (OAS), and myxovirus resistance (Mx) genes from duck. dTLR5 mRNA was highly expressed in the... -
Characterization of Virulence Function of Pseudomonas cichorii Avirulence Protein E1 (AvrE1) during Host Plant Infection
Duyen Do Tran Huong, Nagendran Rajalingam, Yong Hoon Lee 한국식물병리학회 The Plant Pathology Journal 8 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 5호 9 494-501 (8 pages)
Pseudomonas cichorii secretes effectors that suppress defense mechanisms in host plants. However, the function of these effectors, including avirulence protein E1 (AvrE1), in the pathogenicity of P. cichorii, remains unexplored. In this study, to investigate the function of avrE1 in P. cichorii JBC1 (PcJBC1), we created an avrE1-deficient mutant (JBC1ΔavrE1) using CRISPR/ Cas9. The disease severity caused by JBC1ΔavrE1 in tomato plants significantly decreased by reducing water soaking during... -
Purification and Characterization of a Major Extracellular Chitinase from a Biocontrol Bacterium, Paenibacillus elgii HOA73
한국식물병리학회 The Plant Pathology Journal 11 Pages
한국식물병리학회 The Plant Pathology Journal 2017, 33권 3호 10 318-328 (11 pages)
Chitinase-producing Paenibacillus elgii strain HOA73 has been used to control plant diseases. However, the antimicrobial activity of its extracellular chitinase has not been fully elucidated. The major extracellular chitinase gene (PeChi68) from strain HOA73 was cloned and expressed in Escherichia coli in this study. This gene had an open reading frame of 2,028 bp, encoding a protein of 675 amino acid residues containing a secretion signal peptide, a chitin-binding domain, two fibronectin type... -
Rpi-blb2-Mediated Hypersensitive Cell Death Caused by Phytophthora infestans AVRblb2 Requires SGT1, but not EDS1, NDR1, Salicylic Acid-, Jasmonic Acid-, or Ethylene-Mediated Signaling
한국식물병리학회 The Plant Pathology Journal 7 Pages
한국식물병리학회 The Plant Pathology Journal 2014, 30권 3호 3 254-260 (7 pages)
Potato Rpi-blb2 encodes a protein with a coiled-coil-nucleotide binding site and leucine-rich repeat (CC-NBS-LRR) motif that recognizes the Phytophthora infestans AVRblb2 effector and triggers hypersensitive cell death (HCD). To better understand the components required for Rpi-blb2-mediated HCD in plants, we used virus-induced gene silencing to repress candidate genes in Rpi-blb2-transgenic Nicotiana benthamiana plants and assayed the plants for AVRblb2 effector. Rpi-blb2 triggers HCD through...
