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981.

The Hypothalamo-Pituitary-Adrenal (HPA) Axis in Depressed Patients

Byung-Jo Kang, Uriel Halbreich 대한신경정신의학회 신경정신의학 18 Pages

대한신경정신의학회 신경정신의학 1984, 제 23권 제 4호 2 329-346 (18 pages)

Byung-Jo Kang, Uriel Halbreich 저
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- 4,700원
우울증 :환자에서의 시상하부ᅳ뇌하수체_ 부신피질축의 이상소견들은 뇌의 창문으르 역활할지도 모르는 신 경내분비계통이 중요하다는 하나의 좋은 예이 다. 우울증환자에 있어서 중추신경에 작용하는 약물들(amphetamine, insulin, desmethylimipramin, 5-hydroxytryptophan)에 대한 cortis이의 비정상적인 반응은 그 밑바닥에 있는 신경전달물질들의 장애에 대한 단서를 제공해 줄수도 있다. 우울증에 관한 이와같은 연구들은 여 러가지 문제점 들을 내포하고 있다. 예를들면 cortisol분비에 영향을 주는 몇몇 신체적이고...
982.

Role of Nitric Oxide as an Antioxidant in the Defense of Gastric Cells

김혜영(Hye-young Kim), 이은주(Eun-joo Lee), 김경환(Kyung Hwan Kim) 대한약리학회 대한약리학잡지 10 Pages

대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 10 389-398 (10 pages)

김혜영(Hye-young Kim), 이은주(Eun-joo Lee), 김경환(Kyung Hwan Kim) 저
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- 3,000원
protected acetaminophen-induced hepatotoxicity by maintaining glutathione homeostasis. The present study examined the role of nitric oxide in mediating hydrogen peroxide - induced damage to gastric cells. Hydrogen peroxide was generated by glucose oxidase acting on β-D-glucose. L-arginine, NG-nitro-L-arginine methyl ester, or NG-nitro-L-arginine were treated to the cells with glucose/glucose oxidase. Lipid peroxidation and nitrite release and cellular content of glutathione were determined. As...
983.

Effects of Extracellular Ca++on PKC or cAMP-stimulated Increases in LH Release and LHβSubunit mRNA Levels in Rat Anterior Pituitary Cells

박덕배(Deok-bae Park), 김창미(Chang-mee Kim), 천민석(Min-seok Cheon), 유경자(Kyung-za Ryu) 대한약리학회 대한약리학잡지 10 Pages

대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 6 347-356 (10 pages)

박덕배(Deok-bae Park), 김창미(Chang-mee Kim), 천민석(Min-seok Cheon), 유경자(Kyung-za Ryu) 저
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- 3,000원
We examined the effects of EGTA and verapamil on phorbol ester-and forskolin-stimulated LH releases and LHβ subunit mRNA levels in order to verify the role of extracellular Ca++ on PKC- or cAMP-induced increases in LH release and LHβ subunit mRNA levels in cultured anterior pituitary cells of rat. Forskolin-stimulated LHβ subunit mRNA levels as well as LH release were all suppressed by prevention of Ca++ mobilization from extracellular environment, after the treatment of EGTA as a Ca++...
984.

Pharmacological Action Mechanism(s) of Vasodilator Effect of Calcitonin Gene-related Peptide in Rat Basilar Arteries

임병용(Byung Yong Rhim), 홍선화(Sun Hwa Hong), 김치대(Chi Dae Kim), 이원석(Won Suk Lee), 김동헌(Dong Heon Kim), 홍기환(Ki Whan Hong) 대한약리학회 대한약리학잡지 12 Pages

대한약리학회 대한약리학잡지 1996, 제 32권 제 1호 5 39-50 (12 pages)

임병용(Byung Yong Rhim), 홍선화(Sun Hwa Hong), 김치대(Chi Dae Kim), 이원석(Won Suk Lee), 김동헌(Dong Heon Kim), 홍기환(Ki Whan Hong) 저
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- 4,100원
In the present study, we observed change in intracellular Ca2+([Ca2+]i) as measured with the fluorescent Ca2+-indicator fura-2 in association with force development of the rat basilar arteries during activation byK+ depolarizing solution and U46619, a thromboxane analogue, in the absence and the presence of calcitonin-gent related peptide (CGRP). CGRP (30 and 100 nM) caused a concentration-dependent inhibition of U46619-induced contraction with decrease in [Ca2+]i, whereas it did not exert any...
985.

Inverse Agonists at A_1Adenosine Receptors in Rat Cerebral Cortex

박경선(Kyung Sun Park), 양완숙(Wan Suk Yang), 김경환(Kyung Hwan Kim) 대한약리학회 대한약리학잡지 8 Pages

대한약리학회 대한약리학잡지 1996, 제 32권 제 1호 3 23-30 (8 pages)

박경선(Kyung Sun Park), 양완숙(Wan Suk Yang), 김경환(Kyung Hwan Kim) 저
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- 3,000원
on receptors, but they are different from agonist in that they cannot trigger the biological response-i.e., they lack intrinsic efficacy. Recent findings extend the model by indicating that not all antagonists display an intrinsic efficacy of zero but that some display inverse agonism . In the present study we studied the inverse agonism at A1 adenosine receptors in membranes prepared from rat cerebral cortex. Eight commercially available A1 adenosine receptor antagonists (CGS-15943, ADPX, CPT,...
986.

Cellular Mechanism of Nicotine-mediated Intracellular Calcium Homeostasis in Primary Culture of Mouse Cerebellar Granule Cells

김원기(Won-Ki Kim), 배영숙(Young-Sook Pae) 대한약리학회 대한약리학잡지 10 Pages

대한약리학회 대한약리학잡지 1996, 제 32권 제 1호 2 13-22 (10 pages)

김원기(Won-Ki Kim), 배영숙(Young-Sook Pae) 저
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- 3,000원
in cultured glial cells. In cerebellar granule cells nicotine-evoked 45Ca2+ uptake was largely blocked by the NMDA receptor antagonists. Glutamate pyruvate transaminase (GPT). which removes endogenous glutamate, also prevented nicotine effects, implying the indirect involvement of glutamate in nicotine-mediated calcium responses. Fluorometric studies using fura-2 showed two phases of nicotine-evoked [Ca2+]i rises: the initial rising phase and the later plateau phase. Interestingly, the NMDA...
987.

Effect of Ischemic Preconditioning on the Oxygen Free Radical Production in the Post-ischemic Reperfused Heart

박종완(Jong-Wan Park), 김영훈(Young-Hoon Kim), 엄창섭(Chang-Sub Uhm), 배재문(Jae-Moon Bae), 박찬웅(Chan-Woong Park), 김명석(Myung-Suk Kim) 대한약리학회 대한약리학잡지 10 Pages

대한약리학회 대한약리학잡지 1994, 제 30권 제 3호 6 321-330 (10 pages)

박종완(Jong-Wan Park), 김영훈(Young-Hoon Kim), 엄창섭(Chang-Sub Uhm), 배재문(Jae-Moon Bae), 박찬웅(Chan-Woong Park), 김명석(Myung-Suk Kim) 저
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- 3,000원
The protective effect of ischemic preconditioning (PC) on ischemia-reperfusion injury of heart has been reported in various animal species, but without known mechanisms in detail. In an attempt to investigate the cardioprotective mechanism of PC, we examined the effects of PC on the myocardial oxidative injuries and the oxygen free radical production in the ischemia-reperfusion model of isolated Langendorff preparations of rat hearts. PC was performed with three episodes of 5 min ischemia and...
988.

Streptozotocin-유발 당뇨쥐의 시상하부에서 Norepinephrine 함량은 정상이나 In vivo Tyrosine Hydroxylase 활성은 감소함

위명복(Myung-Bok Wie), 송동근(Dong-Keun Song), 강병태(Byung-Tae Kang), 정전섭(Jun-Sub Jung), 최연식(Yeun-Sik Choi), 박준형(Joon-Hyoung Park), 김영희(Yung-H 대한약리학회 대한약리학잡지 6 Pages

대한약리학회 대한약리학잡지 1991, 제 27권 제 1호 1 1-6 (6 pages)

위명복(Myung-Bok Wie), 송동근(Dong-Keun Song), 강병태(Byung-Tae Kang), 정전섭(Jun-Sub Jung), 최연식(Yeun-Sik Choi), 박준형(Joon-Hyoung Park), 김영희(Yung-H 저
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- 3,000원
당뇨쥐에서 시상하부의 norepinephrine(NE) 대사를 기초 NE 함량, NE 교체율, in vivo tyrosine hydroxylase(TH) 활성을 그 지표로 하여 조사하였다. STZ (60 mg/kg, iv)로 당뇨를 유발한 후 4주까지 기초 NE 함량은 유의한 변화가 없었다. 그러나 당뇨유발 후 1주째에 측정한 NE 교체율은 대조치의 62%(p<0.01), in vivo TH 활성은 대조치의 34% (p<0.05)로 감소하였다. 이상의 결과로 본 실험에서 측정한 NE 대사의 세 지표 중에서 in vivo TH 활성이 STZ-유발 당뇨쥐의 시상하부 NE 대사의 변화를 가장 민감하게 반영하였다.
989.

Do Opioid Receptors Play a Role in Blood Pressure Regulation?

Rhee H.M., J.W. Holaday, J.B. Long, M.D. Gaumann, T.L. Yaksh, G.M. Tyce, W.R. Dixon, A.P. Chang, J.A. Mastrianni, R. Mosqueda-Garcia, G. K 대한약리학회 대한약리학잡지 12 Pages

대한약리학회 대한약리학잡지 1988, 제 24권 제 2호 1 153-164 (12 pages)

Rhee H.M., J.W. Holaday, J.B. Long, M.D. Gaumann, T.L. Yaksh, G.M. Tyce, W.R. Dixon, A.P. Chang, J.A. Mastrianni, R. Mosqueda-Garcia, G. K 저
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- 4,100원
rats provide no evidence of sympathetic nervous system involvement in the pressor responses to intravenous injection of opioid peptides, but rather suggest a direct peripheral action. Finally, activation of a beta-endorphinergic pathway projecting from the arcuate nucleus to the nucleus tractos solitarii in rats can cause naloxone reversible hypotension and bradycardia. There is evidence to implicate this pathway in antihypertensive drug action and in the modulation of baroreflex activity.
990.

Effect of Cadmium on Organic Acid Transport System in Renal Basolateral Membrane

Kim, Ghi-Chan, Kim, Kyoung-Ryong, Kim, Jee-Yeun, Park, Yang-Saeng 대한생리학회 대한생리학회지 10 Pages

대한생리학회 대한생리학회지 1996, 제 30권 제 2호 10 279-288 (10 pages)

Kim, Ghi-Chan, Kim, Kyoung-Ryong, Kim, Jee-Yeun, Park, Yang-Saeng 저
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- 3,000원
of Na+-dependent, αKG-driven PAH uptake was observed in normal membrane vesicles directly exposed to inorganic cadmium in vitro, and this was accompanied by an inhibition of both Na+-dependent αKG uptake and αKG-PAH exchange activity. These results indicate that during chronic exposure to cadmium, free cadmium ions liberated in the proximal tubular cytoplasm directly interact with the basolateral membrane and impair the active transport capacity for organic anions, most likely due to an...

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