자료유형
발행기관
- 대한생리학회-대한약리학회(53)
- 대한수의학회(42)
- 대한기생충학회(3)
- 아시아태평양암예방학회(3)
- 한방비만학회(3)
- 대한생리학회(2)
- 대한약리학회(2)
- 대한약학회(2)
- 한국생약학회(2)
- 대한의생명과학회(1)
- 생화학분자생물학회(1)
- 한국미생물생명공학회(1)
- 한국식품영양과학회(1)
간행물
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(53)
- JOURNAL OF VETERINARY SCIENCE(26)
- 대한수의학회 학술대회발표집(9)
- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(7)
- ASIAN PACIFIC JOURNAL OF CANCER PREVENTION : APJCP(3)
- THE KOREAN JOURNAL OF PARASITOLOGY(3)
- 대한한방비만학회지(3)
- ARCHIVES OF PHARMACAL RESEARCH : A PUBLICATION OF THE PHARMACEUTICAL SOCIETY OF KOREA(2)
- NATURAL PRODUCT SCIENCES(2)
- 대한생리학회지(2)
- 대한약리학잡지(2)
- BMB REPORTS(1)
- JOURNAL OF EXPERIMENTAL & BIOMEDICAL SCIENCES(1)
- JOURNAL OF MEDICINAL FOOD(1)
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY(1)
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Changes of colonic endocrine cells in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis
Young Doo Back , Hyeung Sik Lee , In Kwon Chung , Woo Hyun Cheon , Sae Kwang Ku 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 9 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2011, 제 51권 제 2호 1 83-91 (9 pages)
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Pituitary Adenylate Cyclase-activating Polypeptide Inhibits Pacemaker Activity of Colonic Interstitial Cells of Cajal
MeiJinWu, KeunHongKee, JisunNa, SeokWonKim, YouinBae, DongHoonShin, SeokChoi, JaeYeoulJun, Han-SeongJeong, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 6 435-440 (6 pages)
This study aimed to investigate the effect of pituitary adenylate cyclase-activating peptide (PACAP) on the pacemaker activity of interstitial cells of Cajal (ICC) in mouse colon and to identify the underlying mechanisms of PACAP action. Spontaneous pacemaker activity of colonic ICC and the effects of PACAP were studied using electrophysiological recordings. Exogenously applied PACAP induced hyperpolarization of the cell membrane and inhibited pacemaker frequency in a dose-dependent manner (from... -
Suppression of Cyclooxygenase-2 Expression in Colonic Epithelial Cells by Ilekudinol B Isolated from Weigela subsessilis
Park. Hye-Jung, Choi. Yeon-A, Tae. Jin, Kang. Chon-Sik, Kim. Dae-Ki, Thuong. Phuong Thien, Kim. Young-Ho, Bae. Ki-Hwan, Lee. Young-Mi 한국생약학회 Natural product sciences 6 Pages
한국생약학회 Natural product sciences 2006, Vol.12 No.1 38-43 (6 pages)
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Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells
Nam. Seung Taek, Hwang. Jung Hwan, Kim. Dae Hong, Park. Mi Jung, Lee. Ik Hwan, Nam. Hyo Jung, Kang. Jin Ku, Kim. Sung Kuk, Hwang. Jae Sa 생화학분자생물학회 BMB reports 6 Pages
생화학분자생물학회 BMB reports 2014, Vol.47 No.9 494-499 (6 pages)
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Involvement of D2 Receptor on Dopamine-induced Action in Interstitial Cells of Cajal from Mouse Colonic Intestine
Zuoa. Dong Chuan, Shahia. Pawan Kumar, Choia. Seok, Jun. Jae-Yeoul, Park. Jong-Seong 대한의생명과학회 Journal of experimental & biomedical sciences 9 Pages
대한의생명과학회 Journal of experimental & biomedical sciences 2012, Vol.18 No.3 218-226 (9 pages)
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Inhibitory Effects of an Aqueous Extract of Cornus kousa Burg. Leaves on TNF-$alpha$-Induced Chemokine Expression and Monocyte Adhesion to Human Colonic Epithelial Cells
Babu. Dinesh, Thapa. Dinesh, Lee. Jong-Suk, Park. Su-Young, Kim. Ah-Ra, Kim. Young-Heui, Yang. Hong-Chul, Kim. Jung-Ae 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 8 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2009, Vol.32 No.1 91-98 (8 pages)
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Degradation of the Transcription Factors NF-${kappa}B$, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells
Kim. Kyeong Ah, Min. Arim, Lee. Young Ah, Shin. Myeong Heon 대한기생충학회 The Korean journal of parasitology 11 Pages
대한기생충학회 The Korean journal of parasitology 2014, Vol.52 No.5 459-469 (11 pages)
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Entamoeba histolytica Induces Cell Death of HT29 Colonic Epithelial Cells via NOX1-Derived ROS
Kim. Kyeong Ah, Kim. Ju Young, Lee. Young Ah, Min. Arim, Bahk. Young Yil, Shin. Myeong Heon 대한기생충학회 The Korean journal of parasitology 8 Pages
대한기생충학회 The Korean journal of parasitology 2013, Vol.51 No.1 61-68 (8 pages)
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Calpains are Involved in Entamoeba histolytica-Induced Death of HT-29 Colonic Epithelial Cells
Jang. Yun-Soo, Song. Kyoung-Ju, Kim. Ju-Young, Lee. Young-Ah, Kim. Kyeong-Ah, Lee. Sang-Kyou, Shin. Myeong-Heon 대한기생충학회 The Korean journal of parasitology 4 Pages
대한기생충학회 The Korean journal of parasitology 2011, Vol.49 No.2 177-180 (4 pages)
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Kinetin inhibits apoptosis of aging spleen cells induced by D-galactose in rats
Mengyun Li, Wuqing Ouyang*, Xiaoli Wu, Yin Zheng, Yunpeng Wei, Lei An 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 3호 3 353-359 (7 pages)
cytokinin growth factor that exerts several anti-aging and antioxidant effects on cells and organs. To investigate the mechanism underlying apoptotic events in aging cells induced by D-galactose (D-gal), we examined the effect of Kn delivered via nuchal subcutaneous injection on D-gal-induced aging and apoptosis in rats. Our results showed that interleukin (IL)-2 levels and mitochondrial membrane potential (ΔΨm) were decreased by Kn in aging rats while IL-6 production and apoptosis increased.... -
Changes of gastrointestinal argyrophil endocrine cells in the COLO205 tumor-implanted Balb/c-nu/nu mice
Sae kwang Ku, Seung Kyoo Seong, Hyeung sik Lee, Jae hyun Lee 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 4호 1 267-271 (5 pages)
cells in COLO205 showed similar frequencies compared to those of Sham. In the pylorus, the most dramatically decreasement of argyrophil cells were detected in COLO205 compared to that of Sham. Implantation of COLO205 tumor cell line induced severe quantitative changes of argyrophil cell density, and the abnormality in density of GI endocrine cells may contribute to the development of gastrointestinal symptoms such as anorexia and indigestion, frequently encountered in patients with cancer. -
An immunohistochemical study of chromogranin A and Sp-1 immunoreactive cells in the gastrointestinal tract of ovariectomized rats
Sae Kwang Ku, Hyeung Sik Lee, Jae Hyun Lee 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 3호 3 191-196 (6 pages)
A (CGA) and bovine Sp-1 chromogranin (BCG)-immunoreactive (IR)cells in gastrointestinal (GI)tract of osteoporotic Sprague-Dawley rat induced by ovariectomy were studied by immunohistochemical methods. The experimental animals were divided into two groups, one is non-ovariectomized group (Sham)and the other is ovariectomized group (OVX). Samples were collected from each part of GI tract at 10th week after ovariectomy or sham operation. CGA-IR cells were restricted to the stomach regions with... -
Role of mucosal mast cells in visceral hypersensitivity in a rat model of irritable bowel syndrome
Jun-Ho La, Tae-Wan Kim, Tae-Sik Sung, Hyun-Ju Kim, Jeom-Yong Kim, Il-Suk Yang 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 4호 6 319-324 (6 pages)
The involvement of mucosal mast cells (MMC) in the pathophysiology of irritable bowel syndrome (IBS) is still controversial. We aimed to re-evaluate the role of MMC in visceral hypersensitivity associated with IBS using a rat IBS model that develops the IBS symptom after a subsidence of acetic acid-induced colitis. No significant difference in the number of MMC was observed between normal rat colon and IBS rat colon. (61.7 ±2.9/mm 2 in normal vs. 88.7 ±13.3/mm 2 in IBS, p > 0.29). However, the... -
Changes of gastrointestinal argyrophil endocrine cells in the osteoporotic SD rats induced by ovariectomy
Sae-Kwang Ku, Hyeung-Sik Lee, Jae-Hyun Lee 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 3호 1 183-188 (6 pages)
argyrophil endocrine cells in gastrointestinal (GI) tract of osteoporotic Sprague-Dawley rat induced by ovariectomy were studied using Grimelius silver stain. The experimental animals were divided into two groups, one is non-ovariectomized group (Sham) and the other is ovariectomized group (OVX). Samples were collected from each part of GI tract (fundus, pylorus, duodenum, jejunum, ileum, cecum, colon and rectum) at 10th week after ovariectomy or sham operation. In this study, argyrophil cells... -
An immunohistochemical study of the gastrointestinal endocrine cells in the ddY mice
Sae-kwang Ku, Hyeung-sik Lee, Jae-hyun Lee 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 2호 1 87-95 (9 pages)
in the pylorus. Somatostatin-IR cells were detected throughout whole GI tract except for the cecum and rectum and they showed more numerous frequencies in the stomach regions. In addition, glucagon-IR cells were restricted to the fundus, duodenum and jejunum with rare frequencies, and HPP-IR cells were restricted to the rectum only with rare frequency. In conclusion, some strain-dependent unique distributional patterns of gastrointestinal endocrine cells were found in GI tract of ddY mice. -
Regional Distribution and Relative Frequency of Gastrointestinal Endocrine Cells in Large Intestines of C57BL/6 Mice
Tae-Su Ham 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 3호 13 233-238 (6 pages)
the whole large intestinal tract but were most predominant in the colon. Serotonin-IR cells were detected throughout the whole large intestinal tract and showed highest frequency in the colon. Peculiarly, glucagon-IR cells were restricted to the colon with a low frequency. However, no somatostatin-, HPP-, gastrin- and CCK-8-IR cells were found in the large intestinal tract. In conclusion, some peculiar distributional patterns of large intestinal endocrine cells were identified in C57BL/6 mice. -
Dietary zinc inhibits the formation of colonic preneoplastic lesion induced by azoxymethane and dextran sodium sulfate in mice
Hyun Ji Park , Dang Young Kim , Bong Su Kang , Ja Seon Yoon , Jae Hwang Sang Yoon Nam , Young Won Yun , Jong Soo Kim , B 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 10 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2012, 제 52권 제 2호 8 115-124 (10 pages)
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Effects of Lubiprostone on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Colon
Han-YiJiao, DongHyunKim, JungSukKi, KwonHoRyu, SeokChoi, JaeYeoulJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.4 9 341-346 (6 pages)
of gastrointestinal smooth muscles. Interstitial cells of Cajal (ICCs) are pacemaker cells that generate slow-wave activity in smooth muscles. We studied the effects of lubiprostone on the pacemaker potentials of colonic ICCs. We used the whole-cell patch-clamp technique to determine the pacemaker activity in cultured colonic ICCs obtained from mice. Lubiprostone hyperpolarized the membrane and inhibited the generation of pacemaker potentials. Prostanoid EP1, EP2, EP3, and EP4 antagonists... -
Effects of Histamine on Cultured Interstitial Cells of Cajal in Murine Small Intestine
ByungJooKim, YoungKyuKwon, EuiyongKim, InsukSo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 6 149-156 (8 pages)
Interstitial cells of Cajal (ICCs) are the pacemaker cells in the gastrointestinal tract, and histamine is known to regulate neuronal activity, control vascular tone, alter endothelial permeability, and modulate gastric acid secretion. However, the action mechanisms of histamine in mouse small intestinal ICCs have not been previously investigated, and thus, in the present study, we investigated the effects of histamine on mouse small intestinal ICCs, and sought to identify the receptors... -
Mechanisms of Motility Change on Trinitrobenzenesulfonic Acid- Induced Colonic Inflammation in Mice
GabJinCheon, YuanCui, Dong-SooYeon, Seong-ChunKwon, Byong-GonPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 10 437-446 (10 pages)
with loss of haustration, and showed mucosal and mucular edema with inflammatory infiltration. The colonic inflammation is significantly induced the reduction of colonic contractile activity including spontaneous contractile activity, depolarization-induced contractility, and muscarinic acetylcholine receptor-mediated contractile response in circular muscle layer compared to the longitudinal muscle layer. The inward rectification of currents, especially, important to Ca2+ and Na+ influx-induced... -
Proteomic Analysis of Colonic Mucosal Tissue from Tuberculous and Ulcerative Colitis Patients
Seong-ChunKwon, KyungJongWon, SeoungHyoJung, KangPaLee, Dong-YoubLee, Eun-SeokPark, BokyungKim, GabJinCheon, KoonHeeHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 7 193-198 (6 pages)
Changes in the expression profiles of specific proteins leads to serious human diseases, including colitis. The proteomic changes related to colitis and the differential expression between tuberculous (TC) and ulcerative colitis (UC) in colon tissue from colitis patients has not been defined. We therefore performed a proteomic analysis of human TC and UC mucosal tissue. Total protein was obtained from the colon mucosal tissue of normal, TC, and UC patients, and resolved by 2-dimensional... -
Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells
DaeGoonYoo, CukSeongKim, SangKiLee, HyoShinKim, EunJungCho, MyoungSooPark, SangDoLee, JinBongPark, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 4 139-144 (6 pages)
A549 cells. The phosphorylation of p38 MAPK was increased significantly after 5 minutes of treatment with TNF-Ձ, reaching a maximum level at 10 min which persisted for up to 60 min. However, p38MAPK phosphorylation was markedly suppressed in the Ref-1-overexpressed A549 cells. Taken together, our results appear to indicate that Ref-1 negatively regulates COX-2 expression in response to cytokine stimulation via the inhibition of p38 MAPK phosphorylation. In the lung cancer cell lines, Ref-1... -
The Inhibitory Effects of Hydrogen Sulfide on Pacemaker Activity of Interstitial Cells of Cajal from Mouse Small Intestine
ShankarPrasadParajuli, SeokChoi, JunLee, YoungDaeKim, ChanGukPark, ManYooKim, HyunIlKim, CheolHoYeum, JaeYeoulJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 4 83-89 (7 pages)
In this study, we studied whether hydrogen sulfide (H2S) has an effect on the pacemaker activity of interstitial cells of Cajal (ICC), in the small intestine of mice. The actions of H2S on pacemaker activity were investigated using whole-cell patch-clamp technique, intracellular Ca2＋ analysis at 30oC and RT-PCR in cultured mouse intestinal ICC. Exogenously applied sodium hydrogen sulfide (NaHS), a donor of hydrogen sulfide, caused a slight tonic inward current on pacemaker activity in ICC at... -
Voltage-dependent Ca2＋ Current Identified in Freshly Isolated Interstitial Cells of Cajal (ICC) of Guinea-pig Stomach
YoungChulKim, HikaruSuzuki, Wen-XieXu, HikaruHashitani, WoongChoi, Hyo-YungYun, Seon-MeePark6, SeiJinYoun6, Sang-JeonLee, SangJinLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.6 6 323-330 (8 pages)
in interstitial cells of Cajal (ICC) distributed in the myenteric layer (ICC-MY) of guinea-pig antrum. In tissue, ICC-MY showed c-Kit positive reactions and produced driving potentials with the amplitude and frequency of about 62 mV and 2 times min−1, respectively, in the presence of 1</SUP>ՌM nifedipine. Single ICC-MY isolated by enzyme treatment also showed c-Kit immunohistochemical reactivity. These cells were also identified by generation of spontaneous inward current under... -
Characterization of Ionic Currents in Human Neural Stem Cells
ChaeGilLim, Sung-SooKim, HaeyoungSuh-Kim, Young-DonLee, SeungCheolAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 1 131-136 (6 pages)
The profile of membrane currents was investigated in differentiated neuronal cells derived from human neural stem cells (hNSCs) that were obtained from aborted fetal cortex. Whole-cell voltage clamp recording revealed at least 4 different currents: a tetrodotoxin (TTX)-sensitive Na+ current, a hyperpolarization-activated inward current, and A-type and delayed rectifier-type K+ outward currents. Both types of K+ outward currents were blocked by either 5 mM tetraethylammonium (TEA) or 5 mM... -
Inhibition of Pacemaker Activity of Interstitial Cells of Cajal by Hydrogen Peroxide via Activating ATP-sensitive K+ Channels
SeokChoi, ShankarPrasadParajuli, HyeonSookCheong, DilliParasadPaudyal, CheolHoYeum, PyungJinYoon, JaeYeoulJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.1 3 15-20 (6 pages)
To investigate whether hydrogen peroxide (H2O2) affects intestinal motility, pacemaker currents and membrane potential were recorded in cultured interstitial cells of Cajal (ICC) from murine small intestine by using a whole-cell patch clamp. In whole cell patch technique at 30oC, ICC generated spontaneous pacemaker potential under current clamp mode (I=0) and inward currents (pacemaker currents) under voltage clamp mode at a holding potential of 70 mV. When ICC were treated with H2O2 in... -
pH-mediated Regulation of Pacemaker Activity in Cultured Interstitial Cells of Cajal
ByungJooKim, JaeHwaLee, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 2 7-12 (6 pages)
Interstitial cells of Cajal (ICCs) are pacemakers in gastrointestinal tracts, regulating rhythmicity by activating nonselective cation channels (NSCCs). In the present study, we investigated the general characteristics and pH-mediated regulation of pacemaker activity in cultured interstitial cells of Cajal. Under voltage clamp mode and at the holding potential of 60 mV, the I-V relationships and difference current showed that there was no reversal potential and voltage-independent inward...
