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Effects of C18 Fatty Acids on Intracellular Ca2+ Mobilization and Histamine Release in RBL-2H3 Cells
MyungChulKim, MinGyuKim, YoungSooJo, HoSunSong, TaeInEom, SangSooSim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.3 7 241-247 (7 pages)
intracellular Ca2+ mobilization. These data suggest that the underlying mechanism of stearic acid, linoleic acid and α-linolenic acid on intracellular Ca2+ mobilization may differ. Linoleic acid and α-linolenic acid significantly increased histamine release. Linoleic acid (C18:2: ω-6)-induced intracellular Ca2+ mobilization and histamine release were more prominent than α-linolenic acid (C18:3: ω-3). These data support the view that the intake of more α-linolenic acid than linoleic acid is... -
Effects of Ginsenosides on the Mechanism of Histamine Release in the Guinea Pig Lung Mast Cells Activated by Specific Antigen- Antibody Reactions
JaiYoulRo, YoungSooAhn, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 11 445-456 (12 pages)
inhibits the DAG which is produced by the activation of mast cells with antigen-antibody reactions via both phosphatidylinositide-PLC and phosphatidylcholine- PLD systems, and then followed by the inhibition of histamine release. However, Re increases histamine release by stimulation of DAG production, which is mediated by phosphatidylcholine-PLD system rather than by phosphatidylinositide-PLC system, but inhibits the mass DAG production. Thus, it could be inferred that other mechanisms play a... -
Inhibitory Effects of Genistein and Water Extracts of Various Herbs on Histamine Release
Kim. Min-Jeong, Kim. Ja-Young, Kwon. Bin, Ji. Geun-Eog 한국응용생명화학회 Journal of the Korean Society for Applied Biological Chemistry 4 Pages
한국응용생명화학회 Journal of the Korean Society for Applied Biological Chemistry 2011, Vol.54 No.1 95-98 (4 pages)
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Isolation and Identification of Flavonoids from Gujeolcho (Chrysanthemum zawadskii var. latilobum) as Inhibitor of Histamine Release
Shim. Sun-Yup, Kang. Hye-Sook, Sun. Hyeon-Jin, Lee. Young-Ju, Park. Jeong-Ro, Chun. Soon-Sil, Song. Young-Hwan, Byun. Dae-Seok 한국식품과학회 Food science and biotechnology 5 Pages
한국식품과학회 Food science and biotechnology 2012, Vol.21 No.2 613-617 (5 pages)
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The Anti-allergic Effect of Vinegar Treated Small Black Soybean (Glycine max Merr.) is Mediated Through Inhibition of Histamine Release and Inflammatory Cytokine Secretion
Shin. Tae-Yong, Shin. Hye-Young, Lim. Jong-Pil, Jeon. Hoon, Kim. Dae-Keun, Chae. Byeong-Suk, Kwon. Young-Ee, Kang. Sin-Myoung, Chang. Ik 한국생약학회 Natural product sciences 5 Pages
한국생약학회 Natural product sciences 2007, Vol.13 No.4 337-341 (5 pages)
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6-Methoxyluteolin from Chrysanthemum zawadskii var. latilobum Suppresses Histamine Release and Calcium Influx via Down-Regulation of $Fc{varepsilon}RI$ ${alpha}$ Chain Expression
Shim. Sun-Yup, Park. Jeong-Ro, Byun. Dae-Seok 한국미생물생명공학회 Journal of microbiology and biotechnology 6 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2012, Vol.22 No.5 622-627 (6 pages)
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G$alpha$12 and G$alpha$13 Subunits Modulate $Ca^{2+}$-Induced Histamine Release in Human Umbilical Cord Blood-Derived Mast Cells
Ro. Jai-Youl, Kim. Ji-Young, Ha. Ji-Hee, Lee. Chang-Ho 한국미생물생명공학회 Journal of microbiology and biotechnology 7 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2002, Vol.12 No.3 483-489 (7 pages)
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Flavonoids Inhibit Histamine Release and Expression of Proinflammatory Cytokines in Mast Cells
Park. Hyo-Hyun, Lee. So-Young, Son. Hee-Young, Park. Seung-Bin, Kim. Mi-Sun, Choi. Eun-Ju, Singh. Thoudam S.K., Ha. Jeoung-Hee, Lee. Maa 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 9 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2008, Vol.31 No.10 1303-1311 (9 pages)
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The Effect of Acteoside on Histamine Release and Arachidonic Acid Release in RBL-2H3 Mast Cells
Lee. Jin-Hee, Lee. Ji-Yun, Kang. Hyo-Suk, Jeong. Chan-Hun, Moon. Hee, Whang. Wan-Kyunn, Kim. Chang-Jong, Sim. Sang-Soo 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 6 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2006, Vol.29 No.6 508-513 (6 pages)
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Histamine Release by Hydrochloric Acid is Mediated via Reactive Oxygen Species Generation and Phospholipase D in RBL-2H3 Mast Cells
Kim. Chang-Jong, Lee. Seung-Jun, Seo. Moo-Hyun, Cho. Nam-Young, Sohn. Uy-Dong, Lee. Moo-Yeol, Shin. Yong-Kyoo, Sim. Sang-Soo 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 6 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2002, Vol.25 No.5 675-680 (6 pages)
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ATP-Induced Histamine Release Is in Part Related to Phospholipase $A_2$-Mediated Arachidonic Acid Metabolism in Rat Peritoneal Mast Cells
Lee. Yun-Hye, Lee. Seung-Jun, Seo. Moo-Hyun, Kim. Chang-Jong, Sim. Sang-Soo 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 5 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2001, Vol.24 No.6 552-556 (5 pages)
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HISTAMINE RELEASE INDUCED BY DENDROASPIS NATRIURETIC PEPTIDE FROM RAT PERITONEAL MAST CELLS
김재곤, 허선, 백병주, Kim. Jae-Gon, Hur. Sun, Baik. Byeoung-Ju 대한소아치과학회 大韓小兒齒科學會誌 10 Pages
대한소아치과학회 大韓小兒齒科學會誌 2001, Vol.28 No.1 72-81 (10 pages)
Dendroaspis natriuretic peptide (DNP)는 최근에 green Mamba snake Dendroaspis angusticeps의 독(venom)에서 발견된 17개의 아미노산 disulfide링 구조를 포함하는 38개 아미노산 펩티드로 natriuretic peptide family와 그 구조가 비슷하다. Natriuretic peptide family는 사람과 흰쥐 비만세포로부터 히스타민을 유리시킨다고 알려져 있다. 그러나 DNP가 비만 세포로부터 히스타민을 유리 시키는 여부는 밝혀져 있지 않다. 본 연구는 DNP가 흰쥐 복강 비만세포로부터 히스타민을 유리시키는 여부와 함께 히스타민 유리기전을... -
Inhibitory Effects of Ginsenoside Re Isolated from Ginseng Berry on Histamine and Cytokine Release in Human Mast Cells and Human Alveolar Epithelial Cells
Bae. Hye-Min, Cho. Ok-Sun, Kim. Shin-Jung, Im. Byung-Ok, Cho. Soon-Hyun, Lee. Se-Na, Kim. Myung-Gyou, Kim. Kyung-Tack, Leem. Kang-Hyun, K 고려인삼학회 Journal of ginseng research 6 Pages
고려인삼학회 Journal of ginseng research 2012, Vol.36 No.4 369-374 (6 pages)
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Samsoeum inhibits systemic anaphylaxis and release of histamine, cytokine in vivo and in vitro
Kim. Su-Jin, Kim. Na-Hyung, Moon. Phil-Dong, Myung. Noh-Yil, Kim. Min-Chol, Lee. Ki-Taek, Jo. Hyung-Mook, Kim. Na-Hyun, Rim. Hong-Kun, Se 경희한의학연구센터 Oriental pharmacy and experimental medicine : OPEM 13 Pages
경희한의학연구센터 Oriental pharmacy and experimental medicine : OPEM 2009, Vol.9 No.2 115-127 (13 pages)
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Antipruritic effect of curcumin on histamine-induced itching in mice
Han Kyu Lee, Seok Bum Park, Su-youne Chang, Sung Jun Jung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 8 547-554 (8 pages)
acts directly on peripheral nerves. Additionally, curcumin blocked the histamine-induced inward current via activation of TRPV1 (curcumin IC50=523 nM). However, it did not alter chloroquine-induced itching behavior in mice, which is associated with transient receptor potential ankyrin 1 (TRPA1). Taken together, our results suggest that histamine-induced itching can be blocked by topical application of curcumin through the inhibitory action of curcumin on TRPV1 receptors in peripheral nerves. -
Dexmedetomidine Modulates Histamine-induced Ca2+ Signaling and Pro-inflammatory Cytokine Expression
DongkiYang, JeongHeeHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 3 413-420 (8 pages)
selectively agonizing α2 adrenoceptor. Histamine is a pathophysiological amine that activates G protein-coupled receptors, to induce Ca2+ release and subsequent mediate or progress inflammation. Dexmedetomidine has been reported to exert inhibitory effect on inflammation both in vitro and in vivo studies. However, it is unclear that dexmedetomidine modulates histamine-induced signaling and pro-inflammatory cytokine expression. This study was carried out to assess how dexmedetomidine modulates... -
Effects of Histamine on Cultured Interstitial Cells of Cajal in Murine Small Intestine
ByungJooKim, YoungKyuKwon, EuiyongKim, InsukSo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 6 149-156 (8 pages)
with U-73122 (a phospholipase C inhibitor) or 5-fluoro-2-indolyl des-chlorohalopemide (FIPI; a phospholipase D inhibitor) blocked histamine-induced membrane depolarizations in ICCs. On the other hand, KT5720 (a protein kinase A inhibitor) did not block histamine-induced membrane depolarization. These results suggest that histamine modulates pacemaker potentials through H1 receptor-mediated pathways via external Ca2+ influx and Ca2+ release from internal stores in a PLC and PLD dependent manner. -
Effect of Doxorubicin on Catecholamine Release in the Isolated Perfused Rat Adrenal Gland
Dong-YoonLim, Song-HoonOh, Yoo-SeungSeoh, Eun-SookLee, Il-HwanKim, Seong-HoJo, Soon-PyoHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 7 215-224 (10 pages)
rat adrenal gland. However, lower dose of DX did not affect CA secretion by high K, and higher doses of DX reduced time-dependently CA secretion of high K. It is thought that these effects of DX may be mediated by inhibiting both influx of extracellular calcium into the rat adrenomedullary chromaffin cells and intracelluar calcium release from the cytoplasmic store. Also, there was no difference in the mode of action between DX and daunorubicin in rat adrenomedullary CA secretion. -
Influence of Staurosporine on Catecholamine Release Evoked by Cholinergic Stimulation and Membrane Depolarization from the Rat Adrenal Gland
Dong-YoonLim, Yeon-SooChoi, Won-HoYang, Yong-KyoonLee, YongLim, Cheol-HeeChoi, Byung-SikYu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 10 149-158 (10 pages)
of the control release as compared to those in the presence of STS only. These results demonstrate that STS causes the marked inhibition of CA secretion evoked by stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by membrane depolarization, indicating strongly that this effect may be mediated by inhibiting influx of extracellular calcium and release in intracellular calcium in the rat adrenomedullary chromaffin cells through preventing activation of protein kinases.... -
Regulation of Magnesium Release by cAMP during Chemical Hypoxia in the Rat Heart and Isolated Ventricular Myocytes
JinShangKimAntonioScarpa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 8 59-68 (10 pages)
Chemically induced hypoxia has been shown to induce a depletion of ATP. Since intracellular free Mg2 ([Mg2]i) appears to be tightly regulated following cellular energy depletion, we hypothesized that the increase in [Mg2]i would result in Mg2 extrusion following hormonal stimulation. To determine the relation between Mg2 efflux and cellular energy state in a hypoxic rat heart and isolated myocytes, [Mg2]i, ATP and Mg2 content were measured by... -
The Inhibitory Mechanism of Aloe Glycoprotein (NY945) on the Mediator Release in the Guinea Pig Lung Mast Cell Activated with Antigen-Antibody Complexes
JaiYoulRo, ByungChulLee, MyungHeeChung, SeungKiLee, ChungKiSung, KyungHwanKim, YoungInPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 15 119-131 (13 pages)
enzyme digestion， the rough and the discontinuous density percoll gradient method. Mast cells were sensitized with IgG1 (anti-OA) and challenged with ova1bumin. Histamine was assayed by fluorometric ana1yzer， 1eukotrienes by radioimmunoassay. The phospholipase D activity was assessed by the production of 1abe1ed phosphatidy1alcoho1. The amount of mass 1， 2-diacy1g1ycero1 (DAG) was measured by the eH]DAG produced when pre1abe1ed with eH]myristic acid. The phosph01ipid methy1ation was assessed... -
Effects of Histamine H2-Receptor Stimulation on Mg2+ Efflux in Perfused Guinea Pig Heart
Hyung-SubKang, Sung-EunChang, Chang-WonKang, Soo-WanChae, Jin-SangKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 6 49-54 (6 pages)
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흰쥐 대뇌피질 절편에서 허혈에 의한 Norepinephrine 유리에 있어서 Nitric Oxide의 영향 Role of Nitric Oxide in Ischemia-evoked Release of Norepinephrine from Rat Cortex Slices
김기원, 은영아, 김동찬, 조규박, Kee-WonKim, YoungAhEun, Dong-ChanKim, Kyu-ParkCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 8 673-679 (7 pages)
an electron spin trap, inhibited [3H]NE release dose-dependently. Ischemia-evoked [3H]NE release was inhibited by methylene blue, a soluble guanylate cyclase inhibitor, and potentiated by 8-bromo-cGMP, a cell permeable cGMP analog, zaprinast, a cGMP phosphodiesterase inhibitor, and S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide generator. These results suggest that the ischemia-evoked [3H]NE release is mediated by NMDA receptors, and activation of NO system is involved. -
Pharmacological Evidence that Cromakalim Inhibits Ca2+ Release from Intracellular Stores in Porcine Coronary Artery
ByungYongRhim, SunHwaHong, ChiDaeKim, WonSukLee, KiWhanHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 4 27-34 (8 pages)
K channels, 1 ㄍM) was without effect. In addition, cromakalim inhibited the GTPS (100 ㄍM, nonhydrolysable analogue of GTP)-induced increase in [Ca2]i. Based on these results, it is suggested that cromakalim and levcromakalim exert a potent vasorelaxation, in part, by acting on the K channels of the intracellular sites (e.g., sarcoplasmic reticulum membrane), thereby, resulting in decrease in release of Ca2 from the intracellular storage site. -
Hydrocortisone이 적출 흰쥐 부신에서 Histamine의 카테콜아민 분비작용에 미치는 영향
임동윤(Dong-Yoon Lim), 최형호(Hyeong-Ho Choi), 김종인(Jong-In Kim), 강정원(Jeong-Won Kang), 최철희(Cheol-Hee Choi), 오형근(Hyeong-Gueun Oh), 유호진(Ho-Jin 대한약리학회 대한약리학잡지 10 Pages
대한약리학회 대한약리학잡지 1996, 제 32권 제 1호 10 83-92 (10 pages)
hydrocortisone (30uM)이나 합성 글루코콜티코이드인 dexamethasone (30uM)을 각각 20분간 전처치한 후에 현저히 증강되었다. Hydrocortisone에 의한 histamine의 CA 분비의 증강작용은 inositol trisphosphate 수용체 억제제인 heparin (3.56U/ml)으로 천처치시 뚜렷이 억제되었으나 adenylate cyclase의 강력한 활성화제인 forskolin (0.2uM)으로 전처치시 현저히 강화되었다. 이상과 같은 실험 결과를 종합한 결과, hydrocortisone (글루코콜티코이드)은 흰쥐 적출관류 부신에서 histamine의 CA 유리작용을 증강시킬 수 있으며, 이는... -
백서 대뇌피질에서 Opioid Kappa수용체의 Histamine 유리조절기능에 관한 연구
김기원(Kee-Won Kim), 조규박(Kyu-Park Cho) 대한약리학회 대한약리학잡지 10 Pages
대한약리학회 대한약리학잡지 1994, 제 30권 제 1호 1 1-10 (10 pages)
증가되었다. 그러나 Bremazocine과 DIP의 Ki치는 sodium 제거 또는 GTPγS 100μM 첨가에 의해 증가되었다. 그러나 Bremazocine과 DIP의 Ki치는 sodium 제거 또는 GTPγS 첨가에 의해 영향받지 않았다. 1-[3H] histidine을 미리 부하한 대뇌피질 절편에서 30mM K+ 에 의한 [3H] histamine의 유리는 (-)EKC에 의하여 영향받지 않았다. (-)EKC의 histamine유리 억제효과는 naloxone, norbinaltorpmine 또는 bremazocine에 의하여 각각 억제되었다. 본 실험 성적은 백서 대뇌피질에서 histamine의 유리는 이 부위에 존재하는 opioid... -
흰쥐 관류부신에서 Histamine 수용체 활성화가 Catecholamine 분비작용에 미치는 영향
임동윤(Dong-Yoon Lim), 노상현(Sang-Hyun Rho) 대한약리학회 대한약리학잡지 14 Pages
대한약리학회 대한약리학잡지 1993, 제 29권 제 1호 5 43-56 (14 pages)
관찰할 수 있었다. Histamine의 CA 분비작용은 chlorisondamine, diphenhydrarmine, ranitidine, Ca++-free Krebs 용액의 관류, nicardipine 및 TMB-8 등의 전처치로 유의하게 억제 되었으나 pirenzepine의 전처치에 의해서는 별다른 영향을 받지 않았다. 더우기 histamine (6.8 × 10-5M)으로 30분간 관류시킨 후에 ACh (50μg)의 CA 분비작용이 상당히 억제됨을 나타내었다. 이상과 같은 연구 결과로 보아 histamine은 흰쥐 적출관류 부신에서 현저한 CA 분비작용을 나타내었으며 칼슘 의존성이었다. 이러한 CA 분비작용은 H1- 및 H2-... -
다형핵구에 의한 폐포세포 손상에 Histamine이 미치는 영향
김영균, 권순석, 김관형, 한기돈, 문화식, 송정섭, 박성학, Kim. Young-Kyoon, Kwon. Soon-Seog, Kim. Kwan-Hyung, Han. Ki-Don, Moon. Hwa-Sik, Sang. Jeong-Sup, Park. Sun 대한결핵및호흡기학회 결핵 및 호흡기 질환 8 Pages
대한결핵및호흡기학회 결핵 및 호흡기 질환 1992, Vol.39 No.3 228-235 (8 pages)
histamine은 알레르기성 질환 및 일부 호흡기질환의 병인에 중요한 매개물질로 작용하기도 하지만, 다형핵구의 여러 기능들을 조절하는 작용도 하는 것으로 알려져 있다. 따라서 저자를온 다형핵구에 의한 폐조직세포의 손상기전을 보다 명확히 이해하고, 이에 대한 히스타민의 영향을 연구하기 위해 본 연구를 시작하였다. 방법 : $^{51}Cr$을 부착시킨 A549 폐포세포와 4명의 건강한 비흡연자들의 말초 정맥혈로부터 분리한 다형핵구 혹은 다형핵구 상충액을 함께 배양하여 발생되는 폐포세포 손상정도를 $^{51}Cr$-release assay로... -
Influence of Fimasartan (a Novel AT1 Receptor Blocker) on Catecholamine Release in the Adrenal Medulla of Spontaneously Hypertensive Rats
Hyo-JeongLim, Seog-KiLee, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 14 99-109 (11 pages)
CA secretion evoked by Ang II, and cholinergic stimulation (both nicotininc and muscarinic receptors) as well as by membrane depolarization from the rat adrenal medulla. It seems that this inhibitory effect of fimasartan may be mediated by blocking the influx of both Na＋ and Ca2＋ through their ion channels into the rat adrenomedullary chromaffin cells as well as by inhibiting the Ca2＋ release from the cytoplasmic calcium store, which is relevant to AT1 receptor blockade without NO release. -
Effects of Losartan on Catecholamine Release in the Isolated Rat Adrenal Gland
Hae-JeongNoh, Yoon-SungKang, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 10 327-335 (9 pages)
acting as both agonist and antagonist to nicotinic receptors of the rat adrenal medulla, which might be dependent on the concentration. It is also thought that this inhibitory effect of losartan may be mediated by blocking the influx of both Na＋ and Ca2＋ into the rat adrenomedullary chromaffin cells as well as by inhibiting the Ca2＋ release from the cytoplasmic calcium store, which is thought to be relevant to the AT1 receptor blockade, in addition to its enhancement of the CA release. -
Resveratrol Inhibits Nicotinic Stimulation-Evoked Catecholamine Release from the Adrenal Medulla
Seong-ChangWoo, Gwang-MoonNa, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 5 155-164 (10 pages)
to its basal release. Taken together, these experimental results demonstrate that resveratrol can inhibit the CA secretory responses evoked by stimulation of cholinergic nicotinic receptors, as well as by direct membrane-depolarization in the isolated perfused model of the rat adrenal gland. It seems that this inhibitory effect of resveratrol is exerted by inhibiting an influx of both ions through Na＋ and Ca2＋ channels into the adrenomedullary cells as well as by blocking the release of Ca2＋... -
Roles of Dopaminergic D1 and D2 Receptors in Catecholamine Release from the Rat Adrenal Medulla
YoungJooBaek, YooSeongSeo, DongYoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.1 3 13-24 (12 pages)
on the release of catecholamines (CA) evoked by cholinergic stimulation and membrane depolarization from the isolated perfused model of the rat adrenal medulla. SKF81297 (30ՌM) and R-(-)-TNPA (30ՌM) perfused into an adrenal vein for 60 min, produced great inhibition in the CA secretory responses evoked by ACh (5.32×10－3 M), DMPP (10－4 M), McN-A-343 (10－4 M), high K+ (5.6×10－2 M), Bay-K-8644 (10ՌM), and cyclopiazonic acid (10ՌM), respectively. For the release of CA... -
Influence of SKF81297 on Catecholamine Release from the Perfused Rat Adrenal Medulla
Deok-HoChoi, Jong-HeeCha, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 6 197-206 (10 pages)
from the rat adrenal medulla evoked by cholinergic stimulation (both nicotininc and muscarinic receptors) and membrane depolarization. This inhibitory of SKF81297 seems to be mediated by stimulation of dopaminergic D1 receptors located on the rat adrenomedullary chromaffin cells, which are relevant to extra- and intracellular calcium mobilization. Therefore, it is thought that the presence of the dopaminergic D1 receptors may be involved in regulation of CA release in the rat adrenal medulla.
