자료유형
발행기관
- 한국탄소학회(42)
- 대한화학회(31)
- 대한생리학회-대한약리학회(25)
- 대한수의학회(22)
- 대한생리학회(17)
- 대한약리학회(11)
- 한국열환경공학회(6)
- 대한환경공학회(3)
- 물리치료재활과학회(3)
- 한국생물공학회(3)
- 한국미술치료학회(2)
- 한국수산학회(2)
- 한국식물병리학회(2)
- 한국환경과학회(2)
- 대한기계학회(1)
- 대한신경계작업치료학회(1)
- 대한신경정신의학회(1)
- 아세아태평양축산학회(1)
- 한국경호경비학회(1)
- 한국고무학회(1)
- 한국동력기계공학회(1)
- 한국수자원학회(1)
- 한국습지학회(1)
- 한국약제학회(1)
- 한국지반공학회(1)
- 한국초등체육학회(1)
- 한국해양환경공학회(1)
간행물
- CARBON LETTERS(42)
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY(31)
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(25)
- JOURNAL OF VETERINARY SCIENCE(22)
- 대한생리학회지(17)
- 대한약리학잡지(11)
- PHYSICAL THERAPY REHABILITATION SCIENCE(3)
- 열환경공학(3)
- 한국열환경공학회 학술대회지(3)
- ENVIRONMENTAL ENGINEERING RESEARCH(2)
- THE PLANT PATHOLOGY JOURNAL (2)
- 미술치료연구(2)
- 한국생물공학회지(2)
- 한국수산학회지: BULLETIN OF THE KOREAN FISHERIES SOCIETY(2)
- 한국환경과학회지(2)
- ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES(1)
- BIOTECHNOLOGY AND BIOPROCESS ENGINEERING(1)
- JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY(1)
- 고무학회지(1)
- 대한환경공학회지(1)
- 시큐리티연구(1)
- 신경정신의학(1)
- 약제학회지(1)
- 재활치료과학(1)
- 한국동력기계공학회지(1)
- 한국수문학회지(1)
- 한국습지학회지(1)
- 한국지반공학회논문집(1)
- 한국초등체육학회지(1)
- 한국해양환경공학회지(1)
전체 선택해제
총 184건 검색
본문검색 결과만 보기
-
회전매체를 이용한 완전혼합 활성슬러지 공법의 Kinetic Constant의 산정
한국수자원학회 韓國水文學會誌 1994, Vol.27 No.4 49-57 (9 pages)
하수와 우유를 섞은 합성폐수를 처리하기 위해 회전매체를 이용한 완전혼합활성슬러지 공법의 kinetic constant 값을 산정한 결과, <TXT>$K_{m}$</TXT>(유기물제거속도) 값은 저부하의 경우는 3.75~8/hr, 고부하인 경우는 8.57~12.5/hr이며, <TXT>$K_{e}$</TXT>값은 저부하인 경우 0.007~0.03/hr, 고부하인 경우는 0.09/hr로, <TXT>$K_{s}$</TXT>(내호흡계수) 값은 저부하인 경우 1.73~3.68/hr, 고부하인 경우는 3.84~5.75/hr로 나타났으며, Y 값은 0.46gVSS/g<TXT>$BOD_{5}$</TXT>로... -
A Kinetic Analysis of the Thermal Degradation of Pyrolytic Heavy Oils obtained from Kiln Pyrolysis Process
Kyong Hwan Lee, Woo-Teck Kwo, Sea Cheon Oh 한국열환경공학회 열환경공학 8 Pages
한국열환경공학회 열환경공학 2011, 제 8권 2호 1 1-8 (8 pages)
Results of kinetic analysis show that the activation energies are 24.4~26.5 kJ/mol and the reaction orders are 1.0~1.25, respectively. To verify the effectiveness of the kinetic analysis method used in this work, the experimental values were compared with those of the numerical integration results using kinetic parameters obtained in this work. It was found that the kinetic analysis method used in this work gave the reliable kinetic parameters of the thermal degradation of pyrolytic heavy oils. -
Kinetic and multi-parameter isotherm studies of picric acid removal from aqueous solutions by carboxylated multi-walled carbon nanotubes in the presence and absence of ultrasound
Soheila Gholitabar, Hasan Tahermansouri 한국탄소학회 Carbon Letters 11 Pages
한국탄소학회 Carbon Letters 2017, Vol.22 2 14-24 (11 pages)
kinetic studies were well described by the pseudo-second-order kinetic model for both methods. In addition, the adsorption isotherms of picric acid from aqueous solutions on the MWCNTs were investigated using six two-parameter models (Langmuir, Freundlich, Tempkin, Halsey, Harkins-Jura, Fowler- Guggenheim), four three-parameter models (Redlich-Peterson, Khan, Radke-Prausnitz, and Toth), two four-parameter equations (Fritz-Schlunder and Baudu) and one five-parameter equation (Fritz-Schlunder).... -
리파아제에 의한 나프록센 2,2,2-트리플로로에틸 씨오에스터의 Dynamic Kinetic Resolution을 위한 라세미화 촉매로서의 고체 염기
김상범, 원기훈, 문상진, 김광제, 박홍우 한국생물공학회 한국생물공학회지 6 Pages
한국생물공학회 한국생물공학회지 2004, Vol.19 No.3 215-220 (6 pages)
계열의 키랄 의약품의 효소적 dynamic kinetic resolution (DKR) 공정에서 라세미화 염기촉매로 트리 옥틸아민이 지금까지 주로 사용되어 왔으나 반응매질에 녹은 상태로 작용해 회수 및 재사용이 어려웠다. 본 연구에서는 이를 개선하고자 라세미화 반응을 위한 고효율 고체 염기를 탐색해 보았다. 45$^{circ}C$, 아이소옥탄 내에서 (S)-나프록센 2,2,2-트리플로로에틸 씨오에스터를 기질로 무기 염기류, 염기성음이온교환수지류, resin-bound 염기류 등을 시험한 결과, 약염기성 음이온교환수지인 DIAION WA30을 사용하였을 때 가장... -
Comparison of characteristics during backward walking according to various stride frequencies in underwater and ground environments
Hee-joong Kim, Yi-jung Chung 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2018, 제 7권 제 2호 7 83-87 (5 pages)
Objective: The purpose of this study was to investigate the relationship between heart rate (HR), self-awareness of exercise intensity (rating of perceived exertion, RPE), and 5-meter walk test (5MWT) of persons affected by stroke during backward walking according to the preferred stride frequency (PSF), PSF＋3 and PSF＋6 conditions. Design: Cross-sectional study. Methods: A total of 11 persons with stroke (9 males, 2 females) participated voluntarily. All patients underwent backward walking... -
Effects of performing hip abduction and adduction during bridging exercise on trunk and lower extremity muscle activity in healthy individuals
Joo Young Hwang, Woo Young Ahn, Hyo Jae Kim, Je Hyun Woo, Woo Jin Choi, Jae Wook Park, Mi Young Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2017, 제 6권 제 1호 3 14-19 (6 pages)
Objective: To investigate the effect of performing three different bridge exercise conditions on the activities of four different muscles using surface electromyography (sEMG) in healthy young adults. Design: Cross-sectional study. Methods: A total of 20 healthy young adults (10 males, 10 females) voluntarily participated in this study. All subjects randomly performed three different bridge conditions as follows: general bridge exercise, isometric hip abduction (IHAB) with a blue Theraband... -
Effect of light touch on body sway during a stable posture with blocked visual information
Jong-Gun Kim, Jin-Hong Kim, Kwang-Sun Do, Jong-eun Yim 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2016, 제 5권 제 3호 5 138-142 (5 pages)
Objective: The purpose of this study was to investigate how light touch with a finger affects balance ability when a posture is maintained in the condition of visual information blockage and to provide a fundamental material for developing balance ability in the process of rehabilitation treatment. Design: Cross-sectional study. Methods: The study subjects were 17 healthy men and women in their twenties and thirties who were studying at S University in Seoul. The system was comprised of an... -
Changes in hoof kinetics and kinematics at walk in response to hoof trimming
Babak Faramarzi, An Nguyen, Fanglong Dong 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 12 557-562 (6 pages)
by a digital camera. Kinetic and kinematic parameters were recorded before and after trimming. Changes were considered significant when p ＜ 0.05. Vertical force (p = 0.026) and contact pressure (p = 0.006) increased after trimming. Stance-phase duration (p = 0.006), swing-phase duration (p = .023), and gait-cycle duration (p = 0.007) decreased significantly post-trimming. The observed changes in kinetic and kinematic parameters were related to hoof trimming. The reported results underline the... -
Association between endotoxin levels in dust from indoor swine housing environments and the immune responses of pigs
Katharine Roque, Kyung Min Shin, Ji Hoon Jo, Gyeong Dong Lim, Eun Seob Song, So Jung Shin, Ravi Gautam, Jae Hee Lee, Yeon Gyeong Kim, Ah 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 2 331-338 (8 pages)
highly exposed pigs (n = 28) had higher circulating neutrophil and lymphocyte (particularly B cells) counts, IgG and IgE levels, interferon-gamma (IFN and interleukin (IL)-4 productions, and lower IgA levels and tumor necrosis factor-alpha (TNF production. The IL-4, IFN, and TNF levels significantly correlated with endotoxin level and/or pig age. Constant exposure of pigs to high levels of airborne endotoxins can lead to aberrant immune profiles. -
Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with Haemophilus parasuis
Ling Zhang, Li Zhao, Yonghong Liu, Junfeng Liu, Xianqiang Li 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 4호 2 431-437 (7 pages)
A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of a single 40 mg/kg dose. The infected model was established by intranasal inoculation and confirmed by clinical signs, blood biochemistry, and microscopic examinations. Plasma TIL concentrations were determined by a validated high-performance liquid chromatography method with ultraviolet... -
Tissue distribution of marbofloxacin in pigs after a single intramuscular injection
Fan Yang, Yiming Liu, Zhili Li, Yuqin Wang, Baobao Liu, Zhensheng Zhao, Bianhua Zhou, Guoyong Wang 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 2호 6 169-173 (5 pages)
five pigs at 2, 6, 10, 24, 48, 72, and 96 h after administration. Marbofloxacin concentrations were determined by using high-performance liquid chromatography with ultraviolet detection and were subjected to non-compartmental analysis to obtain kinetic parameters. The elimination half-life (t1/2λz) of marbofloxacin at the injection site was 22.12 h, while those in kidney, plasma, liver, lung, heart, and muscle were 16.75, 21.48, 21.84, 24.00, 24.45, and 28.91 h, respectively. Areas under the... -
Toxicity of crude and detoxified Tityus serrulatus venom in anti-venom-producing sheep
Marina G. Ferreira, Clara G. Duarte, Maira S. Oliveira, Karen L. P. Castro, Ma?lson S. Teixeira, L?lian P. G. Reis, Jos? A. Zamb 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 4호 5 467-477 (11 pages)
Specific anti-venom used to treat scorpion envenomation is usually obtained from horses after hyperimmunization with crude scorpion venom. However, immunized animals often become ill because of the toxic effects of the immunogens used. This study was conducted to evaluate the toxic and immunogenic activities of crude and detoxified Tityus serrulatus (Ts) venom in sheep during the production of anti-scorpionic anti-venom. Sheep were categorized into three groups: G1, control, immunized with... -
Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats
Bratislav Dejanovic, Ivana Stevanovic, Milica Ninkovic, Ivana Stojanovic, Irena Lavrnja, Tatjana Radicevic, Milos Pavlovic 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 7 53-61 (9 pages)
This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ... -
Quantitation of meloxicam in the plasma of koalas (Phascolarctos cinereus) by improved high performance liquid chromatography
Benjamin Kimble, Kong Ming Li, Merran Govendir* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 1호 2 7-14 (8 pages)
An improved method to determine meloxicam (MEL) concentrations in koala plasma using reversed phase high performance liquid chromatography equipped with a photo diode array detector was developed and validated. A plasma sample clean-up step was carried out with hydrophilic- lipophilic copolymer solid phase extraction cartridges. MEL was separated from an endogenous interference using an isocratic mobile phase [acetonitrile and 50 mM potassium phosphate buffer (pH 2.15), 45：55 (v：v)] on a... -
Biceps femoris muscle transposition for treatment of cranial cruciate ligament rupture in small breed dogs
Roberto Tamburro*, Stefania Pinna, Anna Maria Tribuiani, Alessandra Panacea, Fabio Carli, Antonio Venturini 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 1호 13 93-98 (6 pages)
The purpose of this study was to evaluate a new extracapsular surgical technique for the treatment of cranial cruciate ligament rupture in small breed dogs. Nine small breed dogs (seven females and two males) weighing ≤ 15 kg were treated with biceps femoris muscle transposition (BFT). The duration of the BFT procedure was 20 min. Each patient underwent a standard clinical protocol and a questionnaire for the owners. Follow-up (at 1, 3, and 12 months postoperative) confirmed significant... -
In vivo metabolism of Talosin A, new isoflavonol glycoside from Kitasatospora kifunensis, in rats
Jong-Hwan Lim, In-Bae Song, Youn-Hwan Hwang, Myoung-Seok Kim, Jong-Woo Kim, Jin-Yong Kim, Joo Won Suh, Hyo-In Yun 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 2호 2 115-120 (6 pages)
The isoflavonol glycoside Talosin A, genistein (GT)-7-a-L-6- deoxy talopyranose (GT-Tal), was first isolated from the culture broth of Kitasatospora kifunensis MJM341. The aim of the present study was to evaluate the oral absorption and metabolism of the newly isolated isoflavonol glycoside, GT-Tal compared to genistin (GT-7-O-b-D-glucopyranoside; GT- Glu). Free GT-Glu and GT-Tal could not be detected prior to enzymatic hydrolysis of the corresponding conjugates in rat plasma. Following oral... -
Determination of angiotensin I-converting enzyme activity in equine blood: lack of agreement between methods of analysis
Maria Fernanda de M. Costa*, Adriana K. Carmona, Marcio F. M. Alves, Timothy M. Ryan, Helen M. Davies, Garry A. Anderson, Ron F. 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 1호 4 21-25 (5 pages)
Angiotensin-I converting enzyme (ACE) is a key regulator of blood pressure, electrolytes and fluid homeostasis through conversion of angiotensin I into angiotensin II. Recently, a genetic polymorphism of the ACE gene, which accounts for 47% of the variation of ACE activity in blood, has been advocated as a biomarker of athletic aptitude. Different methods of analysis and determination of ACE activity in plasma have been used in human and equine research without a consensus of a "gold standard"... -
Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits
B. H. Pavithra, N. Prakash*, K. Jayakumar 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 4호 3 293-297 (5 pages)
Investigation was carried out in adult New Zealand white rabbits to study the influence of curcumin pre-treatment on pharmacokinetic disposition of norfloxacin following single oral administration. Sixteen rabbits were divided into two groups of eight each consisting of either sex. Animals in group-I were administered norfloxacin (100 mg/kg body weight p.o), while animals in group-II received similar dose of norfloxacin after pre-treatment with curcumin (60 mg/kg body weight per day, 3 days,... -
The inhibitory effect of quercitrin gallate on iNOS expression induced by lipopolysaccharide in Balb/c mice
Hyun-Ye Jo, Youngsoo Kim, Sang-Yoon Nam, Beom Jun Lee, Yun-Bae Kim, Young Won Yun, Byeongwoo Ahn 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 3호 6 267-272 (6 pages)
Quercetin 3-O-b-(2"-galloyl)-rhamnopyranoside (QGR) is a naturally occurring quercitrin gallate, which is a polyphenolic compound that was originally isolated from Persicaria lapathifolia (Polygonaceae). QGR has been shown to have an inhibitory effect on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated macrophage RAW 264.7 cells. Therefore, this study was conducted to investigate the inhibitory effect of QGR on nitric oxide production and inducible nitric oxide synthases... -
Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves
Vinod K. Dumka* 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 4호 7 357-360 (4 pages)
The disposition kinetics of levofloxacin was investigated in six male crossbred calves following single intravenous administration, at a dose of 4 mg/kg body weight, into the jugular vein subsequent to a single intramuscular injection of paracetamol (50 mg/kg). At 1 min after the injection of levofloxacin, the concentration of levofloxacin in plasma was 17.2±0.36 ■g/ml, which rapidly declined to 6.39±0.16 ■g/ml at 10 min. The drug level above the MIC90 in plasma, was detected for up... -
Bioavailability of the amino acid-attached prodrug as a new anti-HIV agent in rats
Kyung-Ae Chae, Hee-Jung Cho, Ji-Min Sung, Hee Lee, Dong-Cheol Seo, Jin-Suk Kim, Ho-Chul Shin 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 3호 10 263-267 (5 pages)
The primary objective of this study was to compare the pharmacokinetics of a new anti-human immunodeficiency virus agent 1-(2-amino-pyridin-4-ylmethyl)-6-(3,5-dimethylbenzoyl)- 5-isopropyl-1H-pyrimidine-2,4-dione (VP-0502) with its amino acid prodrug alanine amide of VP-0502 (VP-0502AL), following intravenous and oral administrations to rats. The plasma concentrations of both analytes were analyzed via high-performance liquid chromatography coupled with photodiode-array detection (HPLC-DAD).... -
Disposition kinetics and urinary excretion of cefpirome after intravenous injection in buffalo calves
Neetu Rajput, Vinod K. Dumka, Harpal S. Sandhu 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 1호 4 21-25 (5 pages)
transfer constant from the central to the peripheral compartment, K12 (4.94 ± 0.31/h). The elimination halflife and the volume of distribution were 2.14 ± 0.02 h and 0.42 ± 0.005 l/kg, respectively. Once the distribution equilibrium was reached between the tissues and plasma, the total body clearance (ClB) and the ratio of the drug present in the peripheral to the central compartment (T/P ratio) were 0.14 ± 0.002 l/kg/h and 1.73 ± 0.06, respectively. Based on the pharmacokinetic parameters... -
Pharmacokinetics, urinary excretion and dosage regimen of levofloxacin following a single intramuscular administration in cross bred calves
Vinod K. Dumka, Anil K. Srivastava 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 4호 5 333-337 (5 pages)
of the absorption rate constant (2.14 ± 0.24 /h). The overall systemic bioavailability of levofloxacin, after intramuscular administration, was 56.6 ± 12.4%. The high value of AUC (7.66 ± 0.72 mg . h/ml) reflected the vast area of body covered by drug concentration. Extensive distribution of the drug into various body fluids and tissues was noted by the high value of Vdarea (1.02 ± 0.05 l/kg). The high ratio of AUC/MIC (76.6 ± 7.25) obtained in this study indicated excellent clinical and... -
Subcutaneous pharmacokinetics and dosage regimen of cefotaxime in buffalo calves (Bubalus bubalis)
Suresh Kumar Sharma, Anil Kumar Srivastava 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 2호 4 119-122 (4 pages)
The pharmacokinetics and dosage regimen of cefotaxime following its single subcutaneous administration (10 mg/ kg) were investigated in buffalo calves. Plasma and urine samples were collected over 10 and 24 h post administration, respectively. Cefotaxime in plasma and urine was estimated by microbiological assay technique using E. coli as test organism. The pharmacokinetic profiles fitted one-compartment open model. The peak plasma levels of cefotaxime were 6.48 ± 0.52 ?g/ml at 30 min and the... -
Alteration of pharmacokinetics of oxytetracycline following oral administration of Piper longum in hens
M. Singh, C. Varshneya, R. S. Telang, A. K. Srivastava 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 3호 4 197-200 (4 pages)
The pharmacokinetic profile of orally administered oxytetracycline (10 mg/kg body weight)was studied 7 days post oral treatment of Piper longum (15 mg equivalent/kg) in White Leghorn hens (2-2.8 kg). On the day 8, oxytetracycline (OTC)was administered orally and blood samples were collected from the wing vein in heparinised vials for plasma separation at 0 (pre-treatment), 15, 30, 60, 120, 240, 360, 480 and 600 minutes post OTC administration. Plasma OTC concentrations were determined by... -
Pharmacokinetics and dosage regimen of ceftriaxone in E. coli lipopolysaccharide induced fever in buffalo calves
Manmohan Singh Dardi, Suresh Kumar Sharma, Anil Kumar Srivastava 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 2호 9 147-150 (4 pages)
of ceftriaxone was 79.4 ± 2.37 μg/ml and the drug was detected up to 6 h. The elimination rate constant was 0.35 ± 0.02 /h and elimination half-life was 2.04 ± 0.14 h. The apparent volume of distribution (Vd(area )) and total body clearance (ClB) were 1.21 ± 0.15 l/kg and 0.41 ± 0.03 l/kg/h, respectively. To maintain a minimum therapeutic concentration of 1 μg/ kg, a satisfactory dosage regimen of cefriaxone in febrile buffalo calves is 19 mg/kg followed by 18 mg/kg at 8 h intervals. -
Pharmacokinetics, tissue residue and plasma protein binding of ofloxacin in goats
Himangshu Baruah, Dulal Chandra Roy, Rohini Kumar Roy, Hirendra Nath Khonikor 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 2호 2 97-101 (5 pages)
male goats intravenously (5 mg/kg) to determine its kinetic behavior, tissue residue, in vitro plasma protein binding and to compute a rational dosage regimen. The concentration of ofloxacin in plasma and tissue samples collected at prescheduled time were estimated by using HPLC. The pharmacokinetic parameters were determined by non-compartmental model and plasma protein binding was estimated by equilibrium dialysis technique. The therapeutic concentration (≥0.5 ?g/ml) was maintained up to 36 h... -
Modification of pharmacokinetics of cefotaxime in uranyl nitrate-induced renal damage in black bengal goats
Biswa Priya Dutta, Shiben Chandra Debnath, Tapan Kumar Mandal and Animesh Kumar Chakraborty 대한수의학회 Journal of Veterinary Science 3 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 1호 1 1-3 (3 pages)
Pharmacokinetics of cefotaxime (50mg/kg, i.m.) were studied in both healthy and kidney damaged female black Bengal goats. Uranyl nitrate (0.75mg/kg) was administered intravenously, once daily for five consecutive days to induce kidney damage. The pharmacokinetic variables were calculated in both cases. Kidney damage caused several changes in the determined variables. The Cmax and Cmin of cefotaxime observed at 0.50 and 5 h in normal goats were 24.91 ± 1.51 and 1.22 ± 0.07 μg/ml, respectively,... -
Effect of fever on pharmacokinetics and dosage regimen of intramuscularly administered amikacin in goats
A. K. Agrawal, S. D. Singh, C. Jayachandran 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2001, 제 2권 제 2호 4 91-96 (6 pages)
A comparative pharmacokinetic study of amikacin (10 mg/kg intramuscular) by microbiological assay method in normal and experimentally induced febrile goats revealed that the plasma drug concentrations were significantly higher in febrile condition at most of the time intervals. Various pharmacokinetic parameters like t(1/2), AUC, AUMC, MRT and Vd(area) were significantly higher whereas total body clearance (Cl(B)) was significantly lower in febrile goats as compared to normal goats. Absorption... -
Tricyclic antidepressant amitriptyline inhibits 5-hydroxytryptamine 3 receptor currents in NCB-20 cells
Yong Soo Park, Seok Ho Myeong, In-Beom Kim, Ki-Wug Sung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 12 585-595 (11 pages)
Amitriptyline, a tricyclic antidepressant, is commonly used to treat depression and neuropathic pain, but its mechanism is still unclear. We tested the effect of amitriptyline on 5-hydroxytryptamine 3 (5-HT3) receptor currents and studied its blocking mechanism because the clinical applications of amitriptyline overlapped with 5-HT3 receptor therapeutic potentials. Using a whole-cell voltage clamp method, we recorded the currents of the 5-HT3 receptor when 5-HT was applied alone or co-applied... -
Chronic Ca2+ influx through voltage-dependent Ca2+ channels enhance delayed rectifier K+ currents via activating Src family tyrosine kinase in rat hippocampal neurons
Yoon-SilYang, Sang-ChanJeon, Dong-KwanKim, Su-YongEun, Sung-CherlJung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 14 259-265 (7 pages)
Excessive influx and the subsequent rapid cytosolic elevation of Ca2+ in neurons is the major cause to induce hyperexcitability and irreversible cell damage although it is an essential ion for cellular signalings. Therefore, most neurons exhibit several cellular mechanisms to homeostatically regulate cytosolic Ca2+ level in normal as well as pathological conditions. Delayed rectifier K+ channels (IDR channels) play a role to suppress membrane excitability by inducing K+ outflow in various... -
Minimal systems analysis of mitochondria-dependent apoptosis induced by cisplatin
Ji-YoungHong, KenjirouHara, Jun-WooKim, EisukeF.Sato, EunBoShim, Kwang-HyunCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.4 6 367-378 (12 pages)
mesothelioma H2052 and their ρ0cells lacking mitochondrial DNA (mtDNA). Based on the experiments, a novel mathematical model that can represent the essential dynamics of the mitochondrial apoptotic pathway induced by cisplatin was developed. The kinetic parameter values of the mathematical model were estimated from the experimental data. Then, we have investigated the dynamical properties of this model and predicted the apoptosis levels for various concentrations of cisplatin beyond the range... -
Antinociceptive Effects of Transcytosed Botulinum Neurotoxin Type A on Trigeminal Nociception in Rats
Hye-JinKim, Geun-WooLee, Min-JiKim, Kui-YeYang, Seong-TaekKim, Yong-CheolBae, Dong-KukAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.4 7 349-355 (7 pages)
We examined the effects of peripherally or centrally administered botulinum neurotoxin type A (BoNT-A) on orofacial inflammatory pain to evaluate the antinociceptive effect of BoNT-A and its underlying mechanisms. The experiments were carried out on male Sprague-Dawley rats. Subcutaneous (3 U/kg) or intracisternal (0.3 or 1 U/kg) administration of BoNT-A significantly inhibited the formalin-induced nociceptive response in the second phase. Both subcutaneous (1 or 3 U/kg) and intracisternal (0.3...
