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전체 선택해제
총 292건 검색
본문검색 결과만 보기
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EMI/EMC of 3D IC(Integrated Circuit)
박준서, Park. Jun-Seo 한국전자파학회 電磁波技術 : 韓國電磁波學會誌 10 Pages
한국전자파학회 電磁波技術 : 韓國電磁波學會誌 2011, Vol.22 No.1 42-51 (10 pages)
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TSV 기술을 이용한 3D IC 개발 동향
최광성, 엄용성, 임병옥, 배현철, 문종태, Choi. K.S., Eom. Y.S., Lim. B.O., Bae. H.C., Moon. J.T. 한국전자통신연구원 전자통신동향분석 9 Pages
한국전자통신연구원 전자통신동향분석 2010, Vol.25 No.5 97-105 (9 pages)
중 MCM의 개념을 수직 방향으로 확장시킨 3D IC가 최근 각광을 받고 있다. 이는 물리적인 한계에 부딪힌 반도체 집적 공정의 한계를 극복하여 지속적으로 무어의 법칙에 맞춰 집적도를 향상시킬 수 있을 뿐만 아니라 소재와 공정이 달라도 3차원적으로 집적이 가능하여 메모리와 프로세서로 대표되는 디지털 칩뿐만 아니라 아날로그/RF, 수동소자, 전력소자, 센서/액추에이터, 바이오칩 등을 하나로 패키징 할 수 있는 장점이 있기 때문이다. 이를 통해 성능 향상, 경박단소, 저비용의 부품 개발이 가능하기 때문에 미국, 유럽, 일본 등... -
3D IC에서의 인터페이스 기술
김소영, Kim. So-Yeong 대한전자공학회 電子工學會誌 9 Pages
대한전자공학회 電子工學會誌 2009, Vol.36 No.9 61-69 (9 pages)
본 기고에서는 반도체 3D IC에서 저전력, 고속 신호 전송을 가능하게 하는 다양한 인터페이스 기술에 대하여 알아보았다. Micro-bump나 TSV와 같이 유선으로 신호를 전송하는 방법과, capacitance나 inductance coupling을 이용하여 무선으로 전송하는 기술을 살펴보았다. 최근 TSV 공정 기술이 많이 발전하여, 앞으로 TSV 인터페이스에 기반한 3D IC가 많이 나올 것으로 기대된다. 무선 인터페이스를 사용할 경우, 특히 inductance coupling을 이용한 경우, 낮은 vdd로도 신호전송이 가능하고, pulse width를 줄일 수 있으며, ESD... -
Thermal Issues in 3D IC
신인섭, 김상민, 백승훈, 서문준, 유리은, 신영수, Sin. In-Seop, Kim. Sang-Min, Baek. Seung-Hun, Seo. Mun-Jun, Yu. Ri-Eun, Sin. Yeong-Su 대한전자공학회 電子工學會誌 11 Pages
대한전자공학회 電子工學會誌 2009, Vol.36 No.9 40-50 (11 pages)
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차세대 SiP를 위한 3D TSV IC 기술
박준서, Park. Jun-Seo 대한전자공학회 電子工學會誌 9 Pages
대한전자공학회 電子工學會誌 2009, Vol.36 No.9 20-28 (9 pages)
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TSV 기반 3D IC Pre/Post Bond 테스트를 위한 IEEE 1500 래퍼 설계기술
오정섭, 정지훈, 박성주, Oh. Jungsub, Jung. Jihun, Park. Sungju 대한전자공학회 Journal of the Institute of Electronics Engineers of Korea 6 Pages
대한전자공학회 Journal of the Institute of Electronics Engineers of Korea 2013, Vol.50 No.1 131-136 (6 pages)
칩 적층기술의 발달로 TSV(Through Silicon Via) 기반 3D IC가 개발되었다. 3D IC의 높은 신뢰성과 수율을 얻기 위해서는 pre-bond 와 post-bond 수준에서 다양한 TSV 테스트가 필수적이다. 본 논문에서는 pre-bond 다이의 TSV 연결부에서 발생하는 미세한 고장과 post-bond 적층된 3D IC의 TSV 연결선에서 발생하는 다양한 고장을 테스트할 수 있는 설계기술을 소개한다. IEEE 1500 표준 기반의 래퍼셀을 보완하여 TSV 기반 3D IC pre-bond 및 post-bond의 at speed test를 통하여 known-good-die와 무결점의 3D IC를 제작하고자 한다. -
Implementation of Single-Wire Communication Protocol for 3D IC Thermal Management Systems using a Thin Film Thermoelectric Cooler
Kim. Nam-Jae, Lee. Hyun-Ju, Kim. Shi-Ho 대한전자공학회 Journal of semiconductor technology and science 6 Pages
대한전자공학회 Journal of semiconductor technology and science 2012, Vol.12 No.1 18-23 (6 pages)
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3D IC 패키지를 위한 TSV요소기술
현승민, 이창우, Hyun. Seung-Min, Lee. Chang-Woo 대한용접접합학회 大韓溶接·接合學會誌 6 Pages
대한용접접합학회 大韓溶接·接合學會誌 2009, Vol.27 No.3 4-9 (6 pages)
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3D-IC 전력 공급 네트워크를 위한 최적의 전력 메시 구조를 사용한 전력 범프와 TSV 최소화
안병규, 김재환, 장철존, 정정화, Ahn. Byung-Gyu, Kim. Jae-Hwan, Jang. Cheol-Jon, Chong. Jong-Wha 한국전기전자학회 전기전자학회논문지 7 Pages
한국전기전자학회 전기전자학회논문지 2012, Vol.16 No.2 102-108 (7 pages)
3D-IC는 2D-IC와 비교하여 전력 공급 네트워크 설계 시에 더 큰 공급 전류와 더 많은 전력 공급 경로들 때문에 몇 가지 문제점을 가지고 있다. 전력 공급 네트워크는 전력 범프와 전력 TSV로 구성되고, 각 노드의 전압 강하는 전력 범프와 전력 TSV의 개수와 위치에 따라 다양한 값을 가지게 된다. 그래서 칩이 정상적으로 동작하기 위해서는 전압 강하 조건을 만족시키면서 전력 범프와 전력 TSV를 최적화하는 것이 중요하다. 본 논문에서는 3D-IC 전력 공급 네트워크에서 최적의 전력 메시 구조를 통한 전력 범프와 전력 TSV 최적화를... -
A Performance Analysis for Interconnections of 3D ICs with Frequency-Dependent TSV Model in S-parameter
Han. Ki Jin, Lim. Younghyun, Kim. Youngmin 대한전자공학회 Journal of semiconductor technology and science 9 Pages
대한전자공학회 Journal of semiconductor technology and science 2014, Vol.14 No.5 649-657 (9 pages)
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Kinematic analysis of rowing exercise using a motor-assisted rowing machine for rowers with spinal cord injury
Ju Ri Jeong, Bum Suk Lee, Dae-Sung Park 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 1호 12 69-75 (7 pages)
Objective: We developed a Motor-Assisted Rowing Machine (MARM) for Spinal Cord Injury (SCI), by modification of the Concept II rowing machine, so that the seats could be operated automatically in a backward and forward direction by a motor. Design: Case report. Methods: Motor rowing consisted of a chair with inclination control, a motor system, control button, monitor, program, leg supporter, safety belt, and seat. The patients were 2 men rowing athletes with SCI, classified as American Spinal... -
DIGITAL ART & MEDIA LITERACY -on the Exhibition in GINUSEUM and Collaboration with Community Media Center Incheon
Oh Chang Geun 경인교육대학교 교육연구원 The Journal of Education 10 Pages
경인교육대학교 교육연구원 The Journal of Education 2020, Vol.3 No.2 8 125-134 (10 pages)
This paper explores digital artworks that were mainly exhibited in the art gallery of GINUSEUM in Gyeongin National University of Education, Korea, and in the Community Media Center in Incheon. Last year, nine renowned artists from Korea participated in a media art exhibition titled Media Sensibilia in GINUSEUM. Consequently, a digital installation from the exhibition was invited to the Community Media Center in Incheon, for the experiential education of the residents. The fundamental purpose of... -
Development of pan-serotype real time loop-mediated isothermal amplification assay for visual and real time detection of FMDV circulating in Korea
Da Rae Lim, Yu Ri Park, Min Ji Park, Hye Ryung Kim, Bok Kyung Ku, Jin Ju Nah, Sun Young Park, Sung Hwan Wee, Bo Young Jeon, Hyung Woo Lee 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 144 288-288 (1 pages)
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Non-invasive quantification of hepatic fat content in healthy dogs by using proton magnetic resonance spectroscopy and dual gradient echo magnetic resonance imaging
Francesca Del Chicca, Andrea Schwarz, Dieter Meier, Paula Grest, Annette Liesegang, Patrick R. Kircher 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 14 570-576 (7 pages)
The objective of the present study was to describe two non-invasive methods for fat quantification in normal canine liver by using magnetic resonance imaging (MRI) and spectroscopy. Eleven adult beagle dogs were anesthetized and underwent magnetic resonance examination of the cranial abdomen by performing morphologic, modified Dixon (mDixon) dual gradient echo sequence, and proton magnetic resonance spectroscopy (1H MRS) imaging. In addition, ultrasonographic liver examination was performed,... -
Micro-computed tomography evaluation and pathological analyses of female rats with collagen-induced arthritis
Young Hee Kim, Jin Seok Kang 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 2호 5 165-171 (7 pages)
Imaging techniques have been introduced to assess the efficacy and toxicity of developing pharmaceuticals. The purpose of this study was to perform a comprehensive characterization of collagen-induced arthritis (CIA) in rats using micro-computed tomography (micro-CT) and to compare the results with data from conventional pathological examination. Arthritis was induced by collagen in 24 female Wistar rats. Micro-CT and pathological analyses were performed to assess arthritis progression. Micro-CT... -
Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation
Jung Min Ryu, Woong Yoon, Jae Hong Park, Seung Pil Yun, Min Woo Jang, Ho Jae Han* 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 3호 2 209-214 (6 pages)
Due primarily to the increasing shortage of allogeneic donor organs, xenotransplantation has become the focus of a growing field of research. Currently, micropigs are the most suitable donor animal for humans. However, no standard method has been developed to evaluate the systemic vascular anatomy of micropigs and standard reference values to aid in the selection of normal healthy animals as potential organ donors are lacking. Using 64-channel multidetector row computed tomographic angiography... -
Cellular uptake of magnetic nanoparticle is mediated through energy-dependent endocytosis in A549 cells
Jun-Sung Kim, Tae-Jong Yoon, Kyeong-Nam Yu, Mi Suk Noh, Minah Woo, Byung-Geol Kim, Kee-Ho Lee, Byung-Hyuk Sohn, Seung-Bum Park, 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 4호 3 321-326 (6 pages)
Biocompatible silica-overcoated magnetic nanoparticles containing an organic fluorescence dye, rhodamine B isothiocyanate (RITC), within a silica shell [50 nm size, MNP@SiO2(RITC)s] were synthesized. For future application of the MNP@SiO2(RITC)s into diverse areas of research such as drug or gene delivery, bioimaging, and biosensors, detailed information of the cellular uptake process of the nanoparticles is essential. Thus, this study was performed to elucidate the precise mechanism by which... -
The effects of posterior retraction on the displacement of the maxilla
Bo-Yeong Yoo, Jong-Chul Kim 대한치과교정학회 The Korean Journal of Orthodontics 13 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1996, 제 26권 제 6호 5 691-703 (13 pages)
Three-dimensional finite element model was made from adult skull to find desirable direction of retraction force to treat skeletal class II malocclusion. The retraction force of 400g was applied to the first molar. The direction of the force application was 23° downward, parallel, 23° upward and 45` upward to the occlusal plane. The stress distribution and the displacement within the maxilla were analyzed by three-dimensional finite element method. The findings obtained were as follows: 1.... -
세라믹 브라켓과 교정용 접착제에 따른 전단 결합 강도의 비교 연구
이주원(Joo-Won Lee), 유동환(Dong-Hwan Yoo), 김상철(Sang-Cheol Kim) 대한치과교정학회 The Korean Journal of Orthodontics 12 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1997, 제 27권 제 2호 12 315-326 (12 pages)
여러 세라믹 브라켁과 접착제에 따른 전단 결합 강도를 비교하기 위하여, 영구 소구치 48개를 대상으로 베이스이 유지 형태가 다른 3종의 세라믹 브라켓을 광중합과 화학 중합을 포함한 3종위 교정용 접착제를 사용하여 접착하고 전단 결합 강도와 파절 양상을 관찰한 결과, 화학 중합형 레진으로 접착한 경우 광중합형으로 접착한 경우보다 결합 강도가 높았으며, 화확적 결합을 하는 Starfire 브라켓이, 기계적 결합을 하는 Transcend나, 복합형 결합인 Fascination보다 전단 결합 강도가 낮았다. Trascend는 주고 법랑질과... -
당귀수산, 생강, 커큐민의 대사성 질환과 관련된 일과성 수용체 전압 이온통로조절에 관한 연구
김병주(Byung Joo Kim) 한방비만학회 대한한방비만학회지 9 Pages
한방비만학회 대한한방비만학회지 2018, 제 18권 제 1호 2 10-18 (9 pages)
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Sodium butyrate has context-dependent actions on dipeptidyl peptidase-4 and other metabolic parameters
Eun-SolLee, Dong-SungLee, PrakashRajPeya, Youn-ChulKim, Dae-GilKang, Ho-SubLee, Byung-ChulOh, DaeHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 7 519-529 (11 pages)
Sodium butyrate (SB) has various metabolic actions. However, its effect on dipeptidyl peptidase 4 (DPP-4) needs to be studied further. We aimed to evaluate the metabolic actions of SB, considering its physiologically relevant concentration. We evaluated the effect of SB on regulation of DPP-4 and its other metabolic actions, both in vitro (HepG2 cells and mouse mesangial cells) and in vivo (high fat diet [HFD]-induced obese mice). Ten-week HFD-induced obese C57BL/6J mice were subjected to SB... -
Preventive effects of imperatorin on perfluorohexanesulfonate-induced neuronal apoptosis via inhibition of intracellular calcium-mediated ERK pathway
EunkyungLee, So-YoungChoi, Jae-HoYang, YounJuLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.4 9 399-406 (8 pages)
Early life neuronal exposure to environmental toxicants has been suggested to be an important etiology of neurodegenerative disease development. Perfluorohexanesulfonate (PFHxS), one of the major perfluoroalkyl compounds, is widely distributed environmental contaminants. We have reported that PFHxS induces neuronal apoptosis via ERK-mediated pathway. Imperatorin is a furanocoumarin found in various edible plants and has a wide range of pharmacological effects including neuroprotection. In this... -
4-(Tert-butyl)-2,6-bis(1-phenylethyl)phenol induces pro-apoptotic activity
JunHoKim, YunmiLee, Mi-YeonKim, JaeYoulCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 4 253-259 (7 pages)
Previously, we found that KTH-13 isolated from the butanol fraction of Cordyceps bassiana (Cb-BF) displayed anti-cancer activity. To improve its anti-proliferative activity and production yield, we employed a total synthetic approach and derivatized KTH-13 to obtain chemical analogs. In this study, one KTH-13 derivative, 4-(tert-butyl)-2,6-bis(1-phenylethyl)phenol (KTH-13-t-Bu), was selected to test its anti-cancer activity. KTH-13-t-Bu diminished the proliferation of C6 glioma, MDA-MB-231,... -
Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization
Hyang-AeLee, Sung-AeHyun, Sung-GurlPark, Ki-SukKim, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 15 119-127 (9 pages)
ICa channel blocking with IC50 (the half-maximum inhibiting concentration) values of 0.142, 0.229, and 0.227 nM on NIC, ISR, and AML, respectively. However, ISR shortened both APD50 and APD90 already at 1 μM whereas NIC and AML shortened APD50 but not APD90 up to 30 μM. According to ion channel studies, NIC and AML concentration-dependently inhibited IKr and IKs while ISR had only partial inhibitory effects (<50% at 30 μM). Inhibition of INa was similarly observed in the three CCBs. Since... -
Neural circuit remodeling and structural plasticity in the cortex during chronic pain
WoojinKim, SunKwangKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 1 1-8 (8 pages)
Damage in the periphery or spinal cord induces maladaptive plastic changes along the somatosensory nervous system from the periphery to the cortex, often leading to chronic pain. Although the role of neural circuit remodeling and structural synaptic plasticity in the ‘pain matrix’ cortices in chronic pain has been thought as a secondary epiphenomenon to altered nociceptive signaling in the spinal cord, progress in whole brain imaging studies on human patients and animal models has suggested a... -
Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice
KyungEunKim, HwajinKim, RokWonHeo, HyunJooShin, Chin-okYi, DongHoonLee, HyunJoonKim, SangSooKang, GyeongJaeCho, WanSungChoi, GuSeobRoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 8 451-460 (10 pages)
Sirtuin 1 (SIRT1) is a mammalian NAD＋-dependent protein deacetylase that regulates cellular metabolism and inflammatory response. The organ-specific deletion of SIRT1 induces local inflam-mation and insulin resistance in dietary and genetic obesity. Macrophage-mediated inflammation con-tributes to insulin resistance and metabolic syndrome, however, the macrophage-specific SIRT1 function in the context of obesity is largely unknown. C57/BL6 wild type (WT) or myeloid-specific SIRT1 knockout (KO)... -
Phasic and Tonic Inhibition are Maintained Respectively by CaMKII and PKA in the Rat Visual Cortex
KayoungJoo, ShinHeeYoon, Duck-JooRhie, , Hyun-JongJang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 11 517-524 (8 pages)
Phasic and tonic γ-aminobutyric acidA (GABAA) receptor-mediated inhibition critically regulate neuronal information processing. As these two inhibitory modalities have distinctive features in their receptor composition, subcellular localization of receptors, and the timing of receptor activation, it has been thought that they might exert distinct roles, if not completely separable, in the regulation of neuronal function. Inhibition should be maintained and regulated depending on changes in... -
Inhibition of the Interleukin-11-STAT3 Axis Attenuates Hypoxia-Induced Migration and Invasion in MDA-MB-231 Breast Cancer Cells
Ji-HongLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.5 6 391-396 (6 pages)
Although interleukin-11 (IL-11) has been reported to be elevated in hypoxic tumors and has been associated with a poor prognosis in various cancers, little is known about its precise role in promoting metastasis in hypoxic tumors. In the present study, the molecular mechanism underlying the effects of IL-11 on MDA-MB-231 breast cancer cells migration and invasion in relation to metastasis under hypoxic conditions has been defined. Inhibition of IL-11 expression or function using small... -
Cytotoxicity and Structure-activity Relationships of Naphthyridine Derivatives in Human Cervical Cancer, Leukemia, and Prostate Cancer
YuJinHwang, MiLyangChung, UyDongSohn, ChaeukIm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 7 517-524 (8 pages)
cancer (HeLa), leukemia (HL-60), and prostate cancer (PC-3) cell lines using an MTT assay. Some compounds (14, 15, and 16) were more potent than colchicine against all three human cancer cell lines and compound (16) demonstrated potency with IC50 values of 0.7, 0.1, and 5.1 μM, respectively. Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were used for quantitative structure-activity relationship (QSAR) molecular modeling of these... -
Cytotoxic Activity and Quantitative Structure Activity Relationships of Arylpropyl Sulfonamides
YuJinHwang, SangMinPark, ChulBuYim, ChaeukIm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.3 9 237-243 (7 pages)
their cytotoxicity using MTT assays in prostate cancer PC-3 and leukemia HL-60 cell lines. Some compounds (4, 9, 13, 14, 15, and 20) showed stronger activities than B13 in both tumor cell lines, and compound (15) gave the most potent activity with IC50 values of 29.2 and 20.7 ՌM, for PC-3and HL-60 cells, respectively. Three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis was performed to build highly reliable and predictive CoMSIA models with cross-validated q2... -
2-(4-Hydroxyphenyl)-5-(3-Hydroxypropenyl)-7-Methoxybenzofuran, a Novel Ailanthoidol Derivative, Exerts Anti-Inflammatory Effect through Downregulation of Mitogen-Activated Protein Kinase in Lipopolysaccharide-Treated RAW 264.7 Cells
HyeonJinKim, Jong-GabJun, Jin-KyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.3 6 217-222 (6 pages)
(compounds 1-6). Among them, compound 4, 2-(4-hydroxyphenyl)-5-(3-hydroxypropenyl)-7-methoxybenzofuran, had the lowest IC50 value concerning nitric oxide (NO) release from lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Compound 4 suppressed the generation of prostaglandin (PG) E2 and the expression of inducible NO synthase and cyclooxygenase (COX)-2 induced by LPS, and inhibited the release of LPS-induced pro-inflammatory cytokines from RAW264.7 cells. The underlying mechanism of compound 4... -
Protective Effect of Phosphatidylcholine on Lipopolysaccharide-Induced Acute Inflammation in Multiple Organ Injury
YoonYangJung, YunsungNam, YongSeolPark, HoSungLee, SoonAuckHong, BeomKeunKim, EonSubPark, YoonHeeChung, JiHoonJeong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.3 5 209-216 (8 pages)
Soybean polyunsaturated phosphatidylcholine (PC) is thought to exert anti-inflammatory activities and has potent effects in attenuating acute renal failure and liver dysfunction. The aim of this study was to investigate the effects of PC in protecting multiple organ injury (MOI) from lipopolysaccharide (LPS). Six groups of rats (N=8) were used in this study. Three groups acted as controls and received only saline, hydrocortisone (HC, 6 mg/kg, i.v.) or PC (600 mg/kg, i.p.) without LPS (15 mg/kg,... -
Anti-Oxidative and Anti-Inflammatory Effects of QGC in Cultured Feline Esophageal Epithelial Cells
MyeongJaeLee, HyunJuSong, JunYeongJeong, SunYoungPark, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 12 81-87 (7 pages)
Quercetin-3-O-Ղ-D-glucuronopyranoside (QGC) is a flavonoid glucoside extracted from Rumex Aquaticus Herba. In the present study, anti-oxidative and anti-inflammatory effects of QGC were tested in vitro. Epithelial cells obtained from cat esophagus were cultured. When the cells were exposed to acid for 2 h, cell viability was decreased to 36%. Pretreatment with 50 ՌM QGC for 2 h prevented the reduction in cell viability. QGC also inhibited the productions of intracellular ROS by... -
Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats
BombiLee, BongjunSur, MijungYeom, InsopShim, HyejungLee, Dae-HyunHahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 2 379-386 (8 pages)
The purpose of this study was to evaluate whether berberine (BER) administration could attenuate depression- and anxiety-like behaviors and increase corticotrophin-releasing factor (CRF) and tyrosine hydroxylase (TH) expression following chronic morphine withdrawal in rats. Male rats were exposed to chronic, intermittent, escalating morphine (10∼50 mg/kg) for 10 days. After the last morphine injection, depression- and anxiety-like beahvior associated with morphine discontinuation persisted for... -
Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons
YunjuJin, JunKim, JiyeonKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 10 211-217 (7 pages)
Recent studies have demonstrated that nitric oxide (NO) activates transient receptor potential vanilloid subtype 1 (TRPV1) via S-nitrosylation of the channel protein. NO also modulates various cellular functions via activation of the soluble guanylyl cyclase (sGC)/protein kinase G (PKG) pathway and the direct modification of proteins. Thus, in the present study, we investigated whether NO could indirectly modulate the activity of TRPV1 via a cGMP/PKG-dependent pathway in cultured rat dorsal root... -
Pak1/LIMK1/Cofilin Pathway Contributes to Tumor Migration and Invasion in Human Non-Small Cell Lung Carcinomas and Cell Lines
InseokJang, ByeongTakJeon, EunAeJeong, Eun-JinKim, DawonKang, JongSilLee, BaekGeunJeong, JinHyunKim6, BongHoiChoi6, JungEunLee, JongWooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 2 159-165 (7 pages)
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small cell lung carcinoma (NSCLC). Although both SCCs and ACs have been characterized histologically and clinically, the precise mechanisms underlying their migration and invasion are not yet known. Here, we address the involvement in NSCLC of the p21-associated kinase1 (Pak1)/LIM kinase1 (LIMK1)/cofilin pathway, which recently has been reported to play a critical role in tumor migration and invasion.... -
Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells
YongJinKim, EunAeKim, UyDongSohn, ChulBuYim, ChaeukIm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 14 441-447 (7 pages)
in the MTT assay. Some compounds (12, 15, and 16) showed stronger cytotoxicity than B13 and C6-ceramide against both tumor cell lines, and compound (12) gave the most potent activity with IC50 values of 36 and 9</SUB>ՌM, respectively. Molecular modeling of thiourea B13 analogues was carried out by comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). We obtained highly reliable and predictive CoMSIA models with cross-validated q2... -
Block of hERG K＋ Channel by Classic Histamine H1 Receptor Antagonist Chlorpheniramine
Hee-KyungHong, Su-HyunJo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 12 215-220 (6 pages)
current amplitude at the end of the voltage steps and hERG tail currents. The IC50 of chlorpheniramine-dependent hERG block in Xenopus oocytes decreased progressively relative to the degree of depolarization. Chlorpheniramine affected the channels in the activated and inactivated states but not in the closed states. The S6 domain mutations Y652A and F656A partially attenuated (Y652A) or abolished (F656A) the hERG current block. These results suggest that the H1 antihistamine, chlorpheniramine is... -
PKC-Independent Stimulation of Cardiac Na+/Ca2+ Exchanger by Staurosporine
TongMookKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.5 7 259-266 (8 pages)
[Ca2+]i transients by reverse mode of cardiac Na+/Ca2+ exchanger (NCX1) were recorded in fura-2 loaded BHK cells with stable expression of NCX1. Repeated stimulation of reverse NCX1 produced a long-lasting decrease of Ca2+ transients ('rundown'). Rundown of NCX1 was independent of membrane PIP2 depletion. Although the activation of protein kinase C (PKC) was observed during the Ca2+ transients, neither a selective PKC inhibitor (calphostin C) nor a PKC activator (PMA) changed the degrees of... -
Open Channel Block of Kv3.1 Currents by Genistein, a Tyrosine Kinase Inhibitor
BokHeeChoi, JiHyunPark, SangJuneHahn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.2 3 71-78 (8 pages)
an IC50 value of 15.71⁑0.67μM and a Hill coefficient of 3.28⁑0.35 (n=5). The time constant of activation at a 300 ms depolarizing test pulses from 80 mV to 40 mV was 1.01⁑0.04 ms and 0.90⁑0.05 ms (n=9) under control conditions and in the presence of 20μM genistein, respectively, indicating that the activation kinetics was not significantly modified by genistein. Genistein (20μM) slowed the deactivation of the tail current elicited upon repolarization to... -
Noradrenergic Modulation of Spontaneous Inhibitory Postsynaptic Currents in the Hypothalamic Paraventricular Nucleus
LongHwaLee, WoneeChong, KihoLee, JinBongPark, PanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 2 71-80 (10 pages)
Previous studies have suggested that brain stem noradrenergic inputs differentially modulate neurons in the paraventricular nucleus (PVN). Here, we compared the effects of norepinephrine (NE) on spontaneous GABAergic inhibitory postsynaptic currents (sIPSCs) in identified PVN neurons using slice patch technique. In 17 of 18 type I neurons, NE (30∼100μM) reversibly decreased sIPSC frequency to 41⁑7% of the baseline value (4.4⁑0.8 Hz, p＜0.001). This effect was blocked by yohimbine...
