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전체 선택해제
총 373건 검색
본문검색 결과만 보기
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INCORPORATING PRIOR BELIEF IN THE GENERAL PATH MODEL: A COMPARISON OF INFORMATION SOURCES
Coble. Jamie, Hines. J. W esley 한국원자력학회 Nuclear engineering and technology : an international journal of the Korean Nuclear Society 10 Pages
한국원자력학회 Nuclear engineering and technology : an international journal of the Korean Nuclear Society 2014, Vol.46 No.6 773-782 (10 pages)
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Exploring Cues to Action in Health Belief Model
Hye-Jin Paek, Kyung-Ah Shin, Byoungkwan Lee 한국광고PR실학회 광고PR실학연구 25 Pages
한국광고PR실학회 광고PR실학연구 2017, 제 10권 1호 9 219-243 (25 pages)
The Health Belief Model (HBM) has played a key role in describing, explaining, and predicting health-related outcomes. As one of the major health behavior theories, HBM has been well applied in numerous health-related studies. However, these studies often ignore the original conception of HBM as a theoretical model because they focus mainly on the predictive roles of risk perception variables ? i.e., perceived susceptibility, severity, benefit, and barrier. Within that process, cues to action... -
Primary School Teachers’ Attitudes toward Integration of Students with Disabilities in the General Classroom in Nepal
Jung Dae Young, Smriti Rai 한국통합교육학회 통합교육연구 19 Pages
한국통합교육학회 통합교육연구 2017, 제 12권 제 2호 1 1-19 (19 pages)
This study specifically focused on the differences in attitudes of teachers who have taught students with disabilities and teachers who have never taught students with disabilities. Data was collected through questionnaires and participants were selected via random sampling method. A total of 150 primary school teachers from Kathmandu valley were surveyed. The data was analyzed through t-test to find out the differences in attitudes between the two groups of teachers i.e. those who have taught... -
D-PSA-K: A Model for Estimating the Accumulated Potential Damage on Kiwifruit Canes Caused by Bacterial Canker during the Growing and Overwintering Seasons
한국식물병리학회 The Plant Pathology Journal 8 Pages
한국식물병리학회 The Plant Pathology Journal 2016, 32권 6호 6 537-544 (8 pages)
We developed a model, termed D-PSA-K, to estimate the accumulated potential damage on kiwifruit canes caused by bacterial canker during the growing and overwintering seasons. The model consisted of three parts including estimation of the amount of necrotic lesion in a non-frozen environment, the rate of necrosis increase in a freezing environment during the overwintering season, and the amount of necrotic lesion on kiwifruit canes caused by bacterial canker during the overwintering and growing... -
A Model for Promoting the Development of Basic Dharma Traits in Preschool Children
Sirima Pinyoanyntapong 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 23 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2013, Vol.7 No.3 3 45-67 (23 pages)
or friends. In Phase 2, a model for promoting the BDT of preschool children was developed through learning activities using sets of fables. These learning activities comprised fable books, storytelling activities, and supplementary Dharma activities and were used by the teachers with 326 students selected from the sample of Phase 1 by purposive sampling. The results showed that the model for promoting the BDT could obviously promote higher scores both in general and for all the specific areas. -
사성제 사상에 기초한 유아교사 인성교육 프로그램 개발
오안나, 김혜순 한국종교교육학회 종교교육학연구 23 Pages
한국종교교육학회 종교교육학연구 2022, 제 69권 7 115-137 (23 pages)
연구 목적 본 연구에서는 사성제 사상에 기초한 유아교사 인성교육 프로그램을 개발함을 연 구 목적으로 한다. 연구 내용 유아교사 인성교육 프로그램을 개발하기 위해 우선 관련 문헌고찰과 선행연구를 분석하고 전문가 집단 면담을 실시하였다. 이후 전문가 집단을 대상으로 3차의 델파이 조사 및 예비연구를 시행하여 내용 타당도를 검증하였다. 이러한 일련의 과정을 거쳐 최종적으로 구성된 프로그램의 목적은 사성제 사상을 토대로 유아교사가 자신을 바르게 이해하고, 올바른 삶의 방식을 깨달아 인성을 함양하는 것으로... -
The Role of Religion in Contemporary Education
Maarten Meijer 한국종교교육학회 종교교육학연구 15 Pages
한국종교교육학회 종교교육학연구 2010, 제 34권 1 1-15 (15 pages)
Both classical philosophy and contemporary research suggest education should provide young people with opportunities to develop themselves in a well-balanced manner: Academic and intellectual advancement should take place in the context of spiritual and moral growth. This, however, is not happening in the national education system of any nation today. On the contrary, with the advancement of modern science and technology, materialism and consumerism are on the rise, and spirituality and... -
Effects of real-time feedback training on weight shifting during golf swinging on golf performance in amateur golfers
Ji-Hyun Hwang, Ho-Suk Choi, Won-Seob Shin 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2017, 제 6권 제 4호 6 189-195 (7 pages)
real-time feedback on weight shift (experimental group) swing training on the Wii balance board (WBB) by viewing the center of pressure (COP) trajectory on the WBB. All participants were assigned to the experimental group and the control group. The general golf swing training group (control group) performed on the ground. The golf performance was measured using a high-speed 3-dimensional camera sensor which analyses the shot distance, ball velocity, vertical launch angle, horizontal launch angl... -
Changes in hoof kinetics and kinematics at walk in response to hoof trimming
Babak Faramarzi, An Nguyen, Fanglong Dong 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 12 557-562 (6 pages)
Appropriate hoof preparation and symmetry are linked to the well-being of the horse. Previous studies have shown the efficacy of pressure plates (PPs) in delivering objective biomechanical analysis. We aimed to assess the effect of hoof trimming on hoof biomechanics using a PP. Nine clinically sound Arabian horses were walked across a PP while foot strike was recorded by a digital camera. Kinetic and kinematic parameters were recorded before and after trimming. Changes were considered... -
Antepartal insulin-like growth factor concentrations indicating differences in the metabolic adaptive capacity of dairy cows
Marion Piechotta*, Lars Holzhausen, Marcelo Gil Araujo, Maike Heppelmann, Anja Sipka, Chistiane Pfarrer, Hans-Joachim Schuberth, 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 3호 2 343-352 (10 pages)
Cows with different Insulin-like Growth Factor-I (IGF-I) concentrations showed comparable expression levels of hepatic growth hormone receptor (GHR). Suppressor of cytokine signaling 2 (SOCS2), could be responsible for additional inhibition of the GHR signal cascade. The aims were to monitor cows with high or low antepartal IGF-I concentrations (IGF-I or IGF-I), evaluate the interrelationships of endocrine endpoints, and measure hepatic SOCS2 expression. Dairy cows (n = 20) were selected (240 to... -
Tactics of Mycobacterium avium subsp. paratuberculosis for intracellular survival in mononuclear phagocytes
Seng-Ryong Woo, Charles J. Czuprynski* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 1호 1 1-8 (8 pages)
Johne's disease is a condition that refers to chronic granulomatous enteritis in ruminants. It is believed that survival and replication of Mycobacterium (M.) paratuberculosis in mononuclear phagocytes plays an important role in the pathogenesis of Johne's disease. However, it is not clear how M. paratuberculosis survives for long time periods in mononuclear phagocytes, nor is it clear which factors trigger multiplication of these bacilli and result in the development of Johne's disease.... -
Birth of puppies after intrauterine and intratubal insemination with frozen-thawed canine semen
Hye Jin Kim, Hyun Ju Oh, Goo Jang, Min Kyu Kim 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 1호 11 75-80 (6 pages)
The present study was performed to assess the fertility of frozen-thawed dog semen prepared by freezing with 6% glycerol and thawing at 70ºC for 8 sec, and to evaluate the least number of post-thaw spermatozoa necessary to achieve pregnancy by intrauterine or intratubal artificial insemination. It was found that the pregnancy rate of intrauterine artificial insemination was 100% using 6% glycerol buffer and thawing at 70ºC for 8 sec with 5 × 107 spermatozoa. Even though the pregnancy rate... -
Risk factors for delayed conception in Korean dairy herds
Ill-Hwa Kim, Hyun-Gu Kang 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 4호 13 381-385 (5 pages)
stepwise procedure was used to obtain the appropriate model (α = 0.05), which revealed the herd, metritis and ovarian cysts to be significant risk factors for delayed conception. The odds ratio showed that the likelihood of delayed conception increased by 3.3 and 2.0 fold for each incidence of metritis and ovarian cysts, respectively. Delayed conception was significantly more likely in 2 herds, in herd A by 2.0 fold and in herd B by 2.4 fold, compared with herd H. These results suggest that the... -
Risk factors for retained placenta and the effect of retained placenta on the occurrence of postpartum diseases and subsequent reproductive performance in dairy cows
Yeon-Kyung Han, Ill-Hwa Kim 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 1호 8 53-59 (7 pages)
stepwise procedure, used to obtain the appropriate model with α = 0.05, revealed that abnormal partus and gestation length were important risk factors for retained placenta. The occurrence of endometritis and metabolic disorders was greater (p < 0.01) in the group with retained placentas than in the control group. The mean intervals from calving to first service and conception were prolonged (p < 0.05) by 7 and 18 days, respectively, in the group with retained placentas compared to the control... -
Inherited canine copper toxicosis in Australian Bedlington Terriers
Changbaig Hyun and Lucio John Filippich 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 1호 4 19-28 (10 pages)
states were noticed in a genotyped carrier dog. Histopathological and electron microscopy findings showed that the severity of the lesion was more closely correlated to the presence of clinical signs than to hepatic copper concentration. In addition, the involvement of apoptosis and p53 gene was observed in electron microscopy. The general findings related to CT-BT in this study was similar to those previously reported except few differences in histopathology and electron microscopy. -
Influences on Teachers’ Career Decision: Perspectives from Pre-Service Music Teachers in Korea
신지혜(Jihae Shin) 한국음악교육공학회 음악교육공학 17 Pages
한국음악교육공학회 음악교육공학 2017, 제 32호 14 257-273 (17 pages)
Recruitment of people of sufficient quality into the teaching profession is one of the most important issues for educators around the country. The purpose of this study was to investigate influences critical to Korean students’ decisions to pursue the music teaching profession. Research questions in the current study indicated the following statements: (a) When did they decide to become a music teacher? (b) Who were the people influencing that decision? (c) What experiences influenced Korean... -
음악교사 전문성 강화를 위한 교사학습공동체 운영방안탐색 - FGI 조사 및 IPA 메트릭스 분석을 바탕으로 -
한국음악교육학회 음악교육연구 2022, 제 51권 제 2호 6 115-146 (32 pages)
본 연구는 서울지역 음악교사들의 학습공동체 참여실태를 분석하고 음악교육전문성 강 화를 위한 학습공동체 운영 및 지원방안을 탐색하는 데 목적이 있다. 이를 위해 서울음악교사 120명을 대상으로 학습공동체 참여실태를 조사하였고, 수석교사, 교수, 교사를 대상 그룹별 FGI 실시 후, SPSS 21.0을 활용하여 빈도분석, 교차분석, IPA 매트릭스 분석을 하였다. 주요결과는 다음과 같다. 첫째, 음악교사의 근무교 유형, 학력, 연령은 학습공동체 필요성 인식, 참여양상에 통계적으로 유의미한 차이를 보였다. 둘째,... -
초등음악수업에서 학생이 지각한 교사지지, 자기효능감, 음악학습동기의 관계
한국음악교육학회 음악교육연구 2022, 제 51권 제 2호 3 47-74 (28 pages)
본 연구는 초등음악수업에서 학생이 지각한 교사지지와 자기효능감, 음악학습동기의 관 계를 살펴보고 자기효능감의 매개효과 여부를 검증하는 것을 목적으로 한다. 이를 위해 서울과 인천에 재학 중인 초등학교 4~6학년 학생 301명을 대상으로 학생이 지각한 교사지지, 자기효능 감, 음악학습동기를 검사 도구를 사용하여 분석하였다. 분석 결과 첫째, 학생이 지각하는 교사지 지는 학생의 음악학습동기에 직접적으로 긍정적인 영향을 주었고 자기효능감을 매개로 하여서 도 음악학습동기에 긍정적인 영향을 주었다. 둘째, 학생이... -
특수교육 교육과정과 교육정책의 연계 분석을 통한 실용음악교육 적용 방안
강윤정, 강래형 한국음악교육학회 음악교육연구 24 Pages
한국음악교육학회 음악교육연구 2021, 제 50권 제 4호 1 1-24 (24 pages)
본 연구는 2015 개정 특수교육 교육과정과 2020년도 특수교육 운영계획에 따른 교육정 책의 연계 분석을 통해 특수교육 내 실용음악교육의 적용 방안을 모색하는 것에 목적을 두었다. 문헌 분석을 실시한 결과, 실용음악교육은 다양하고 균등한 교육 제공, 음악교육 범주의 세분화, 진로 탐색 및 설계 지원, 요구를 반영한 프로그램을 개설⋅운영할 수 있는 수용 가능성을 지니 고 있다. 이를 토대로 학생과 교사를 위한 다각화된 교육 프로그램, 교육과정 및 방과후학교 내 실용음악교육 활성화, 교외 자원을 활용한 전문화된... -
A Study of Singapore Music Teacher Training System
Mikyung Rim, Eunsil Park, Hye-Suk Lim 한국음악교육학회 음악교육연구 21 Pages
한국음악교육학회 음악교육연구 2020, 제 49권 제 2호 8 197-217 (21 pages)
The purpose of this study was to explore the characteristics of Singapore's music teacher training process. The research method was to investigate and analyze the information regarding this topic mainly through the web sites of Singapore Ministry of Education, National Institute of Education, Nanyang Technological University and Ats Institutes in Singapore. The results of the study are: 1) Singapore has three tracks of music teacher training courses(diploma, bachelor degree, postgraduate degree... -
교육연구에서 f-NIRS의 실제 측정과 적용을 통한 두뇌 연구의 탐색
박상희, 박진선, 황나래, 권승혁, 권용주 한국교원대학교 뇌기반교육연구소 Brain, Digital, & Learning 19 Pages
한국교원대학교 뇌기반교육연구소 Brain, Digital, & Learning 2019, 제 9권 제 3호 9 213-231 (19 pages)
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구순구개열 발생의 분자유전학 연구를 위한 유전자 표적/적중 생쥐모델의 이용
백진아 대한구순구개열학회 대한구순구개열학회지 6 Pages
대한구순구개열학회 대한구순구개열학회지 2008, 제 11권 2호 3 65-70 (6 pages)
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자비명상에 기반한 부모교육프로그램 개발과 효과
안혜원, 천성문, 김아영, 김희진 한국교육치료학회 교육치료연구 17 Pages
한국교육치료학회 교육치료연구 2019, Vol.11 No.1 6 115-131 (17 pages)
본 연구는 자비명상에 기반한 부모교육프로그램을 개발하여 적용하고 부모를 대상으로 그 효과를 검증하는 데 그 목적이 있다. 이를 위해 천성문 등(2017)의 상담 프로그램 개발모형에 따라 부모교육에 참가한 경험이 있는 부모들의 요구와 부모교육 및 자비명상 전문가들의 자문을 바탕으로 부모들의 자기자비와 심리적 안녕감을 증진시키고 양육스트레스를 감소시키기 위한 10회기 프로그램을 개발하였다. 프로그램의 효과를 검증하기 위하여 B시에 거주하는 부모들 중 프로그램에 참가하기를 희망하는 20명을 실험집단과 통제집단에... -
Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth
Dong Ho Bak, Mi Ji Choi, Soon Re Kim, Byung Chul Lee, Jae Min Kim, Eun Su Jeon, Wonil Oh, Ee Seok Lim, Byung Cheol Park, Moo Joong Kim, Ju 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 9 555-566 (12 pages)
Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) are used in tissue repair and regeneration; however, the mechanisms involved are not well understood. We investigated the hair growth-promoting effects of hUCB-MSCs treatment to determine whether hUCB-MSCs enhance the promotion of hair growth. Furthermore, we attempted to identify the factors responsible for hair growth. The effects of hUCB-MSCs on hair growth were investigated in vivo, and hUCB-MSCs advanced anagen onset and hair... -
Genistein attenuates isoflurane-induced neurotoxicity and improves impaired spatial learning and memory by regulating cAMP/CREB and BDNF-TrkB-PI3K/Akt signaling
TaoJiang, Xiu-qinWang, ChuanDing, Xue-lianDu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 2 579-589 (11 pages)
BDNF and TrkB mRNA levels. Genistein effectively upregulated cAMP levels and phosphorylation of CREB and TrkB, leading to activation of cAMP/CREB-BDNF-TrkB signaling. PI3K/Akt signaling was also significantly activated. Genistein administration improved general behavior and enhanced learning and memory in the rats. These observations suggest that genistein exerts neuroprotective effects by suppressing isoflurane-induced neuronal apoptosis and by activating cAMP/CREB-BDNF-TrkB-PI3/Akt signaling. -
The effects of intra-articular resiniferatoxin on monosodium iodoacetate-induced osteoarthritic pain in rats
YoungkyungKim, Eun-hyeKim, KyuSangLee, KoeunLee, , SungHoPark, , SookHyunNa, CheolwoongKo6, JunesunKim, YoungWookYooon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 16 129-136 (8 pages)
in a rat model of osteoarthritis (OA). We also sought to determine the effect of RTX treatment on calcitonin gene-related peptide (CGRP) expression in the spinal cord. Knee joint inflammation was induced by intra-articular injection of monosodium iodoacetate (MIA, 8 mg/50 µl) and weight bearing percentage on right and left hindpaws during walking, paw withdrawal threshold to mechanical stimulation, and paw withdrawal latency to heat were measured to evaluate pain behavior. Intra-articular... -
Effect of Vitamin E Supplementation on Intestinal Barrier Function in Rats Exposed to High Altitude Hypoxia Environment
ChunlanXu, RuiSun, XiangjinQiao, CuicuiXu, XiaoyaShang, WeiningNiu, YuChao 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.4 5 313-320 (8 pages)
The study was conducted to investigate the role of vitamin E in the high altitude hypoxia-induced damage to the intestinal barrier in rats. Sprague-Dawley rats were divided into control (Control), high altitude hypoxia (HH), and high altitude hypoxia＋vitamin E (250 mg/kg BW*d) (HV) groups. After the third day, the HH and HV groups were placed in a hypobaric chamber at a stimulated elevation of 7000 m for 5 days. The rats in the HV group were given vitamin E by gavage daily for 8 days. The other... -
Hypericum Perforatum Decreased Hippocampus TNF-α and Corticosterone Levels with No Effect on Kynurenine/Tryptophan Ratio in Bilateral Ovariectomized Rats
WesamMEl-Bakly, AmanyHHasanin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.3 6 233-239 (7 pages)
to ovariectomized untreated rats. It is concluded that increased tryptophan metabolism toward kynurenine secondary to elevated corticosterone and TNF-α might be one of the pathohphysiological mechanisms that could explain depression like state observed in this rat model. Further, the observed attenuating effect of HP on TNF-α and corticosterone could contribute in its antidepressant effect in this animal model by other ways than their effects on tryptophankynurenine metabolism pathway. -
The Pathophysiologic Roles of TRPM7 Channel
HyunSooPark, ChansikHong, ByungJooKim, InsukSo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 2 15-23 (9 pages)
Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg2＋ and Ca2＋, and its channel activity is negatively regulated by free Mg2＋ and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell... -
Spontaneous Electrical Activity of Cultured Interstitial Cells of Cajal from Mouse Urinary Bladder
Sun-OuckKim, Han-SeongJeong, SujeongJang, Mei-JinWu, JongKyuPark, Han-YiJiao, JaeYeoulJun, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 9 531-536 (6 pages)
Interstitial cells of Cajal (ICCs) from the urinary bladder regulate detrusor smooth muscle activities. We cultured ICCs from the urinary bladder of mice and performed patch clamp and intracellular Ca2+ ([Ca2+]i) imaging to investigate whether cultured ICCs can be a valuable tool for cellular functional studies. The cultured ICCs displayed two types of spontaneous electrical activities which are similar to those recorded in intact bladder tissues. Spontaneous electrical activities of cultured... -
The Effect of Metformin Treatment on CRBP-I Level and Cancer Development in the Liver of HBx Transgenic Mice
Jo-HeonKim, Md.MorshedulAlam, DoekBaePark, MoonjaeCho, Seung-HongLee, You-JinJeon, Dae-YeulYu, TaeDuKim6, HaYoungKim, ChungGuCho, DaeHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 12 455-461 (7 pages)
Retinoids regulate not only various cell functions including proliferation and differentiation but also glucose and lipid metabolism. After we observed a marked up-regulation of cellular retinol-binding protein-I (CRBP-I) in the liver of hepatitis B virus x antigen (HBx)-transgenic (HBx Tg) mice which are prone to hepatocellular carcinoma (HCC) and fatty liver, we aimed to evaluate retinoid pathway, including genes for the retinoid physiology, CRBP-I protein expression, and retinoid levels, in... -
A Review on Renal Toxicity Profile of Common Abusive Drugs
VarunParkashSingh, NirmalSingh, AmteshwarSinghJaggi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 13 347-357 (11 pages)
Drug abuse has become a major social problem of the modern world and majority of these abusive drugs or their metabolites are excreted through the kidneys and, thus, the renal complications of these drugs are very common. Morphine, heroin, cocaine, nicotine and alcohol are the most commonly abused drugs, and their use is associated with various types of renal toxicity. The renal complications include a wide range of glomerular, interstitial and vascular diseases leading to acute or chronic renal... -
Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases
RaviKant, AnjanaBali, NirmalSingh, AmteshwarSinghJaggi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 1 111-120 (10 pages)
Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well in the systemic circulation. Over a period of time, a number of prolyl hydroxylase inhibitors and activators have been developed. By employing the pharmacological tools and transgenic knock out animals, the critical role of these enzymes has been established in the... -
Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders
LeeyupChung, AlexraL.Bey, Yong-HuiJiang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 1 369-378 (10 pages)
Analysis of synaptic plasticity together with behavioral and molecular studies have become a popular approach to model autism spectrum disorders in order to gain insight into the pathosphysiological mechanisms and to find therapeutic targets. Abnormalities of specific types of synaptic plasticity have been revealed in numerous genetically modified mice that have molecular construct validity to human autism spectrum disorders. Constrained by the feasibility of technique, the common regions... -
Functional Expression of TRPV4 Cation Channels in Human Mast Cell Line (HMC-1)
KyungSooKim, DongHoonShin, JooHyunNam, KyungSunPark, YinHuaZhang, WooKyungKim, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 11 419-425 (7 pages)
Mast cells are activated by specific allergens and also by various nonspecific stimuli, which might induce physical urticaria. This study investigated the functional expression of temperature sensitive transient receptor potential vanilloid (TRPV) subfamily in the human mast cell line (HMC-1) using whole-cell patch clamp techniques. The temperature of perfusate was raised from room temperature (RT, 23∼25oC) to a moderately high temperature (MHT, 37∼39oC) to activate TRPV3/4, a high temperature... -
The Effects of Astragalus Membranaceus on Repeated Restraint Stress-induced Biochemical and Behavioral Responses
Hyun-JungPark, HyunYoungKim, Kun-HoYoon, KyungSooKim, InsopShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 8 315-319 (5 pages)
Astragalus Membranaceus (AM) is a useful Korean herb that has been clinically prescribed for stress-related illness. The objective of the present study was to examine the anti-stress effects of AM on repeated stress-induced alterations of anxiety, learning and memory in rats. Restraint stress was administered for 14 days (2h/day) and AM (400mg/kg) given by oral administration, in the AM group, for the same period. Starting on the eighth day, the rats were tested for spatial memory on the Morris... -
The Effects of Puerariae Flos on Stress-induced Deficits of Learning and Memory in Ovariectomized Female Rats
Hyun-JungPark, Seung-MooHan, WonJuYoon, Kyung-SooKim, InsopShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 3 85-90 (6 pages)
Puerariae flos (PF) is a traditional oriental medicinal plant and has clinically been prescribed for a long time. The purpose of the present study was to examine the effect of PF on repeated stress-induced alterations of learning and memory on a Morris water maze (MWM) test in ovariectomized (OVX) female rats. The changes in the reactivity of the cholinergic system were assessed by measuring the immunoreactive neurons of choline acetyltransferase (ChAT) in the hippocampus after behavioral... -
Maternal Social Separation of Adolescent Rats Induces Hyperactivity and Anxiolytic Behavior
HyongRyolKwak, JaeWonLee, Kwang-JunKwon, ChangDonKang, IlYoungCheong, WanjooChun, Sung-SooKim, HeeJaeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 2 79-84 (6 pages)
hyperactivity and anxiolytic behavior in the open field test, elevated plus-maze test, and forced-swim test. Biologically, the number of astrocytes was significantly increased in the prefrontal cortex of MSS adolescent rats. The hyperactive and anxiolytic phenotype and biological alteration produced by this MSS protocol may provide a useful animal model for investigating the neurobiology of psychiatric disorders of childhood-onset diseases, such as attention deficient hyperactive disorder. -
Neurovascular Mechanisms in Stroke, Neurodegeneration and Recovery
EngH.Lo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 1 223-230 (8 pages)
The emerging concept of the“neurovascular unit”may enable a powerful paradigm shift for neuroscience. Instead of a pure focus on the“neurobiology”of disease, an opportunity now exists to return to a more integrative approach. The neurovascular unit emphasizes that signaling between vascular and neuronal compartments comprise the basis for both function and dysfunction in brain. Hence, brain disorders are not just due to death of neurons, but instead manifested as cell signaling perturbations... -
Inhibition of Nitric Oxide-induced Neuronal Apoptosis in PC12 Cells by Epigallocatechin Gallate
JiYeonJung, YeonJinJeong, ChangRyoungHan, SunHunKim, HyunJinKim, KiHeonLee, HaOkPark, WonJaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.4 8 239-246 (8 pages)
In the central nervous system, nitric oxide (NO) is associated with many pathological diseases such as brain ischemia, neurodegeneration and inflammation. The epigallocatechin gallate (EGCG), a major compound of green tea, is recognized as protective substance against neuronal diseases. This study is aimed to investigate the effect of EGCG on NO-induced cell death in PC12 cells. Administration of sodium nitroprusside (SNP), a NO donor, decreased cell viability in a dose- and time-dependent... -
Inhibition of Hypoxia-induced Apoptosis in PC12 Cells by Estradiol
JiYeonJung, KwangHoonRoh, YeonJinJeong, SunHunKim, EunJuLee, MinSeokKim, WonMannOh, HeeKyunOh, WonJaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.4 7 231-238 (8 pages)
Neuronal apoptotic events, which result in cell death, are occurred in hypoxic/ischemic conditions. Estradiol is a female sex hormone with steroid structure known to provide neuroprotection through multiple mechanisms in the central nervous system. This study was aimed to investigate the signal transduction pathway of CoCl2-induced neuronal cell death and the inhibitory effects of estradiol. Administration of CoCl2 decreased cell viability in both a dose- and time-dependent manner in PC12 cells....
