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Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function
JaeGooKim, MinSooKim, SeoulLee, GunTaeKim, JongDooLee, DongGooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 6 113-119 (7 pages)
showed impaired fore-paw muscle power in the wire maneuver test. These groups also showed decreased white matter volume and increased serotonergic fibers. The LPS and NAN-190-treated group also exhibited neurologic deficit in the placing reaction test and impaired equilibrium function in the tilt table test. The results showed that a variety of altered behaviors can be generated by two factor model, and suggested that combination of important etiologic factors and possible underlying defects is... -
c-fos mRNA Expression in the Vestibular System following Hypergravity Stimulation in Rats
GuangShiJin, JaeHyoLee, JaeHeeLee, MoonYoungLee, MinSunKim, YuanZheJin, JeongHoonSong, ByungRimPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.1 1 1-7 (7 pages)
force of 2 g (twice earth's gravity) for 1, 3, or 12 h, and were examined poststimulus at 0, 2, 6, 12, and 24 h. RT-PCR (reverse transcription polymerase chain reaction) and real-time quantitative RT-PCR were adopted to analyze temporal changes in the expression of c-fos mRNA. The hypergravity stimulus increased the expression of c-fos mRNA in the vestibular ganglion, medial vestibular nucleus, inferior vestibular nucleus, hippocampus, cerebellum, and cortex. The peak expression occurred at 0 h... -
Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis
ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 3 131-142 (12 pages)
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or His). Such channels are highly selective for K+, but show inward rectification that is a shallow function of voltage compared with that found in wild type. This inward rectification occurs with a reduced affinity for spermine and persists in the absence of polyamines. Though the unitary current-voltage relation... -
Modulation of Inwardly Rectifying K+ Channel by Intracellular and Extracellular pH in Bovine Aortic Endothelial Cells
Kyu-SangPark, InDeokKong, JoongWooLee, HyewhonRhim, YoungChulKim, InsukSo, KiWhanKim, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 4 255-260 (6 pages)
in BAECs using reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. Intracellular alkalinization, elicited by the extracellular substitution of NaCl with NH4Cl (30 mM), significantly augmented the amplitude of IRK current. On the contrary, the amplitude of IRK current was attenuated by the Na-acetate (30 mM)-induced intracellular acidification. The changes in extracellular pH also closely modulated the amplitude of IRK current, which was decreased to 40.2⁑1.3% of control upon... -
Muscarine M2 Receptor-mediated Presynaptic Inhibition of GABAergic Transmission in Rat Meynert Neurons
Il-SungJangNorioAkaike 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 1 63-70 (8 pages)
Cholinergic modulation of GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) by the activation of muscarine receptors was investigated in mechanically dissociated rat nucleus basalis of the Meynert neurons using the conventional whole-cell patch recording configuration. Muscarine (10μM) reversibly and concentration-dependently decreased mIPSC frequency without affecting the current amplitude distribution. Muscarine action on GABAergic mIPSCs was completely blocked by... -
Effects of Ethanol on Na+-dependent Solute Uptake in Rabbit Renal Brush-Border Membrane Vesicles
YongKeunKim, SunHeeKo, JaeSukWoo, JinSupJung, SangHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 9 191-198 (8 pages)
This study was undertaken to examine the effect of ethanol on Na-dependent transport systems (glucose, phosphate, and dicarboxylate) in renal brush-border membrane vesicles (BBMV). Ethanol inhibited Na- dependent uptakes of glucose, phosphate, and succinate in a dose-dependent manner, but not the uptakes of Na-independent. The H/TEA antiport was reduced by 8% ethanol. Kinetic analysis showed that ethanol caused a decrease in Vmax of three transport systems, leaving... -
Regulation of Magnesium Release by cAMP during Chemical Hypoxia in the Rat Heart and Isolated Ventricular Myocytes
JinShangKimAntonioScarpa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 8 59-68 (10 pages)
Chemically induced hypoxia has been shown to induce a depletion of ATP. Since intracellular free Mg2 ([Mg2]i) appears to be tightly regulated following cellular energy depletion, we hypothesized that the increase in [Mg2]i would result in Mg2 extrusion following hormonal stimulation. To determine the relation between Mg2 efflux and cellular energy state in a hypoxic rat heart and isolated myocytes, [Mg2]i, ATP and Mg2 content were measured by... -
Pharmacological Characterization of Synthetic Tetrahydroisoquinoline Alkaloids, YS 51 and YS 55, on the Cardiovascular System
Ki-ChurlChang, Young-JinKang, Young-SooLee, Won-SeogChong, Hye-SookYun-Choi, Duck-HyongLee, Jae-ChunRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 8 461-469 (9 pages)
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines, and many of them, especially with 6,7-disubstitution, demonstrate relatively high affinity for catecholamines. Two -OH groups at 6 and 7 positions are supposed to be essential to exert -receptor activities. However, it is not clear whether -OH at 6,7 substitution of THIs also shows -adrenoceptor activities. In the present study, we investigated whether -OH or -OCH3... -
알코올의존과 도파민 D2 수용체 TaqI A1 대립유전자의 관련
홍경수, 김종원, 김길숙, 오동열, 김승태 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 1997, 제 36권 제 6호 13 1089-1098 (10 pages)
알코올의존의 유전적 원인론을 추구하는 일련의 연구결과 중 전세계적으로 논란이 되고 있는 도파민 D2 수용체 유전자 TaqI A1 대립유전자와 알코올의존의 유전적 관련(genetic association) 여부를 단일인종인 우리나라 인구를 대상으로 검증해 보고자 본 연구를 시행하였다. 환자군은 DSM-IV에 근거하여 알코올의존으로 진단내려진 남자 입원환자 59명이며, 대조군은 알코올의 존이 배제되고 2차친척 내에 알코올의존 환자가 없는 74명의 정상인이었다. 알코올의존의 심한정도는 미국 National Council on Alcoholism(NCA)의... -
5HT2A /T102C 다형성과 정신 분열병 및 임상아형과의 관련연구
홍현상, 백인호, 도규영, 김정진, 이창욱, 이철 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 1998, 제 37권 제 4호 11 719-727 (9 pages)
목 적： 가계연구, 입양연구, 쌍생아연구들은 정신분열병의 원인으로 유전학적 요소가 매우 중요하다는 것을 지적 해 주고 있다. 그러나 정신분열병의 유전적인 복잡성으로 인하여 많은 연구들이 시행되었음에도 유전방식이 나 원인 유전자를 밝히지는 못하였다. 최근에는 5HT2A 수용체가 비정형항정신병약물의 주된 작용부위라는 것이 밝혀지면서 5HT2A 수용체의 유전자가 정신분열병의 원인과 관련이 있을 것이라는 관심이 늘어나게 되 었다. 따라서 저자들은 한국인 정신분열병환자들을 대상으로 5HT2A 수용체 T102C 다형성과의...
