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511.

Effect of Defibrotide on Rat Reflux Esophagitis

HyoungKiKim, SooRanChoi, SangJinChoi, MyungSupChio, YongKyooShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 5 319-328 (10 pages)

HyoungKiKim, SooRanChoi, SangJinChoi, MyungSupChio, YongKyooShin 저
...
- 3,000원
This study was aimed at evaluating the effect of defibrotide on the development of the surgically induced reflux esophagitis, on gastric secretion, lipid peroxidation, polymorphonuclear leukocytes (PMNs) accumulation, polymorphonuclear leukocytes adherence, superoxide anion and hydrogen peroxide production in PMNs, scavenge of hydroxyl radical and hydrogen peroxide, cytokine (interleukin-1β, tumor necrosis factor-α) production in blood, and intracellular calcium mobilization in PMNs....
512.

Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis

ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 3 131-142 (12 pages)

ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 저
...
- 4,100원
to account for that seen under whole cell recording. Channels open and shut under single channel recording, and changes of Popen appear to generate inward rectification. In D172H, the reduction in affinity for spermine is greater when His is protonated at low pHi. The effective valency for spermine is reduced from 3.09⁑0.07 in wild type to 1.95⁑0.09 in D172H at pHi 6.3. In the presence of dual mutants of Kir2.1, where E224 is also replaced, spermine affinity becomes undetectable....
513.

Inhibition of DNA-dependent Protein Kinase by Blocking Interaction between Ku Complex and Catalytic Subunit of DNA-dependent Protein Kinase

Chung-HuiKim, DangVanCuong, Jong-SuKim, NariKim, EuiyongKim, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 3 9-14 (6 pages)

Chung-HuiKim, DangVanCuong, Jong-SuKim, NariKim, EuiyongKim, JinHan 저
...
- 3,000원
in damage-signaling pathway and/or DNA repair. This would greatly facilitate tumor cell cytotoxic activity and programmed cell death through DNA damaging drug treatment. Therefore, we designed a domain of Ku80 mutants that binds to Ku70 but not DNA end binding activity and used the peptide in co-therapy strategy to see whether the targeted inhibition of DNA-PK activity sensitized breast cancer cells to irradiation or chemotherapy drug. We observed that the synthesized peptide (HNI-38) prevented...
514.

Neuroprotective Effect of 8-OH-DPAT on Long-term Sequelae from Prenatal Ischemia in Rats

SeoulLee, TieYuanZhang, GunTaeKim, HeeSooKim, JongDooLee, JeongWonJahng, DongGooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 3 293-297 (5 pages)

SeoulLee, TieYuanZhang, GunTaeKim, HeeSooKim, JongDooLee, JeongWonJahng, DongGooKim 저
...
- 1,500원
The role of 5-hydroxytryptamine (5-HT)1A receptor activity in prenatal ischemia was studied, by injecting 8-hydroxy-dipropylaminotetraline (8-OH-DPAT; 50μg/kg, s.c.), a 5-HT1A agonist on gestation day 17, and 30 min later inducing transient ischemia by ligating the uterine vessels for 30 min. On postnatal day 95, rats that had experienced prenatal ischemia showed impaired motor coordination and reduced concentration of 5-HT in the cerebellum compared with Sham-operated controls. In addition,...
515.

Block of ATP-Sensitive K Channels Expressed in Xenopus Oocytes by Dimethyl Sulfoxide

JinBongParkSooWanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 6 157-163 (7 pages)

JinBongParkSooWanChae 저
...
- 3,000원
K channel subunit Kir6.2, and the other expressing renal KATP channel ROMK2. At concentrations of 0.3∼10% (vol/vol) DMSO inhibited whole cell Kir6.2/SUR1 currents elicited by bath application of sodium azide (3 mM) in a concentration-dependent manner. The inhibition constant and Hill coefficient were 2.93% and 1.62, respectively. ROMK2 currents, however, was not affected significantly by DMSO. The results support the idea that DMSO inhibits KATP channel expressed in Xenopus oocyte through a...
516.

Cadmium Inhibition of Renal Endosomal Acidification

MooSeongKim, KyoungRyongKim, DoWhanAhn, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 9 63-72 (10 pages)

MooSeongKim, KyoungRyongKim, DoWhanAhn, YangSaengPark 저
...
- 3,000원
Chronic exposure to cadmium (Cd) results in an inhibition of protein endocytosis in the renal proximal tubule, leading to proteinuria. In order to gain insight into the mechanism by which Cd impairs the protein endocytosis, we investigated the effect of Cd on the acidification of renal cortical endocytotic vesicles (endosomes). The endosomal acidification was assessed by measuring the pH gradient-dependent fluorescence change, using acridine orange or FITC-dextran as a probe. In renal endosomes...
517.

Chemical Coupling between Horizontal Cells in the Catfish Retina

Sung-JongLee, Chang-SubJung, Sun-HoBai 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 3 21-30 (10 pages)

Sung-JongLee, Chang-SubJung, Sun-HoBai 저
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- 3,000원
518.

정신분열병과 22번 염색체 인터루킨-2 수용체 β-chain 유전자의 연관성

김용구, 이민수, 김인, 곽동일, 서광윤 대한신경정신의학회 신경정신의학 12 Pages

대한신경정신의학회 신경정신의학 1998, 제 37권 제 3호 11 515-526 (12 pages)

김용구, 이민수, 김인, 곽동일, 서광윤 저
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- 4,100원
연구배경： 정신분열병이 유전적이라고 제시하는 많은 역학 연구와 유전자 연구에도 불구하고, 이 질환의 유전방식과 질병유전자는 밝혀져 있지 않다. 본 연구에서는 정신분열병과 22번 염색체 장완의 11.2-12 부위에 위치한 Interleukin-2 수용체 β chain 유전자간에 유전적 연합을 조사하고자 정신분열병 환자 93명과 정상대조군 97명을 대상으로 중합효소연쇄반응을 이용하여 Interleukin-2 수용체 β chain(IL-2Rβ) 유전자의 다형 성 분포를 조사하였다. 방 법： 환자군은 DSM-Ⅲ-R 진단기준에 따라 임상아형(망상형, 붕괴형,...
519.

애착장애 아동에서 99m-Tc-ECD-SPECT로 측정한 뇌혈류량의 양상

천근아, 이경숙, 신의진 대한신경정신의학회 신경정신의학 11 Pages

대한신경정신의학회 신경정신의학 2001, 제 40권 제 1호 10 98-108 (11 pages)

천근아, 이경숙, 신의진 저
...
- 4,000원
연구목적： 아동 학대 또는 방치와 같은 병적인 양육환경이 신경생물학적인 변화를 야기할 수 있다는 가정 하에, 심각 한 주양육자와의 애착관계의 문제를 보이는 아동들을 대상으로 SPECT를 이용한 뇌 혈류 양상을 알아보고 뇌의 비정상 소견 여부를 관찰하고자 한다. 방 법： 연구대상은 반응성애착장애(reactive attachment disorder)로 진단된 2∼6세 아동 12명으로 구성되었다. 진단도구로서 DSM-IV, ICD-10, 낯선상황절차(Strange Situation Procedure), 사회성숙도 검사(Social Maturity Scale), 아동기 자폐증 평가척도(Childhood...
520.

치료저항성 강박장애의 약물학적 치료 및 통합적 치료 모형의 제안

권준수, 하태현 대한신경정신의학회 신경정신의학 12 Pages

대한신경정신의학회 신경정신의학 2003, 제 42권 제 3호 2 302-313 (12 pages)

권준수, 하태현 저
...
- 4,100원

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