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81.

유아교사의 성격강점과 행복과의 관계에서 직무스트레스 대처방식의 매개효과

박은아, 김원 한국교육치료학회 교육치료연구 18 Pages

한국교육치료학회 교육치료연구 2015, Vol.7 No.3 12 545-562 (18 pages)

박은아, 김원 저
...
- 4,700원
본 연구는 유아교사의 성격강점과 행복과의 관계에서 직무스트레스 대처방식의 매개효과를 확인하 고자 함을 목적으로 한다. 이를 위하여 유아교사 460명을 표집하였고 성격강점과 행복과의 관계에 서 직무스트레스 대처방식이 매개변인으로 작용할 것이라는 연구모형을 설정하였다. 결과는 첫째, 유아교사의 성격강점, 행복, 직무스트레스 대처방식 중 문제해결중심 대처방식과 지지추구중심 대처 방식은 모두 정적상관이 있었다. 둘째. 모형검증 결과 완전매개모형도 유의하였고 부분매개모형도 유의한 것으로 나타났다. 그 중 최적의...
82.

대학생용 직업 자기효능감 척도의 개발과 타당화

이정애, 최웅용 한국교육치료학회 교육치료연구 20 Pages

한국교육치료학회 교육치료연구 2015, Vol.7 No.1 3 35-54 (20 pages)

이정애, 최웅용 저
...
- 4,900원
본 연구는 대학생들을 위한 직업 자기효능감 척도를 개발하고 그 타당성을 검증하는데 목적이 있 다. 이를 위해 기존 척도들의 구성요인을 검토하여 Holland 유형에 대한 효능감을 측정하는 직업 자 기효능감 척도를 개발하였고, 개발된 검사의 타당도와 신뢰도를 검증하였다. 대학생을 대상으로 설 문을 실시하였으며, 총 523부의 자료를 분석에 사용하였다. 탐색 및 확인적 요인분석 결과, Holland 유형의 6가지 요인구조가 확인되었다. 공인 및 수렴타당도를 검증하기 위해 기존의 단축형 직업 자 기효능감 척도 및 직업 자기효능감...
83.

Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder

Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 6 525-538 (14 pages)

Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hahm 저
...
- 4,300원
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported pharmacological properties of tetramethylpyrazine (TMP) include anti-cancer, anti-diabetic, anti-atherosclerotic, and neuropsychiatric activities. However, the anxiolytic-like effects of TMP and its mechanism of action in PTSD are unclear. This study measured several...
84.

The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain

MinJoonKim, JiHwanLee, JoUngJang, FuShiQuan, SunKwangKim, WoojinKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 11 657-666 (10 pages)

MinJoonKim, JiHwanLee, JoUngJang, FuShiQuan, SunKwangKim, WoojinKim 저
...
- 3,000원
Paclitaxel, a chemotherapeutic drug, induces severe peripheral neuropathy. Gabapentin (GBT) is a first line agent used to treat neuropathic pain, and its effect is mediated by spinal noradrenergic and muscarinic cholinergic receptors. Electro-acupuncture (EA) is used for treating various types of pain via its action through spinal opioidergic and noradrenergic receptors. Here, we investigated whether combined treatment of these two agents could exert a synergistic effect on paclitaxel-induced...
85.

Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model

HwayoungLee, JiyunIm, HansolWon, WooyoungNam, YoungOckKim, SangWonLee, SanghyunLee, Ik-HyunCho, Hyung-KiKim, Jun-TackKwon, Hak-JaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 1 361-370 (10 pages)

HwayoungLee, JiyunIm, HansolWon, WooyoungNam, YoungOckKim, SangWonLee, SanghyunLee, Ik-HyunCho, Hyung-KiKim, Jun-TackKwon, Hak-JaeKim 저
...
- 3,000원
Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM...
86.

Prediction of pharmacokinetics and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach: A case study of caffeine and ciprofloxacin

Min-HoPark, Seok-HoShin, Jin-JuByeon, Gwan-HoLee, Byung-YongYu, YoungG.Shin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 13 107-115 (9 pages)

Min-HoPark, Seok-HoShin, Jin-JuByeon, Gwan-HoLee, Byung-YongYu, YoungG.Shin 저
...
- 3,000원
Over the last decade, physiologically based pharmacokinetics (PBPK) application has been extended significantly not only to predicting preclinical/ human PK but also to evaluating the drug-drug interaction (DDI) liability at the drug discovery or development stage. Herein, we describe a case study to illustrate the use of PBPK approach in predicting human PK as well as DDI using in silico, in vivo and in vitro derived parameters. This case was composed of five steps such as: simulation,...
87.

Neuroprotective effect of caffeic acid phenethyl ester in 3-nitropropionic acid-induced striatal neurotoxicity

JiaBak, HeeJungKim, SeongYunKim, Yun-SikChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 7 279-286 (8 pages)

JiaBak, HeeJungKim, SeongYunKim, Yun-SikChoi 저
...
- 3,000원
Caffeic acid phenethyl ester (CAPE), derived from honeybee hives, is a bioactive compound with strong antioxidant activity. This study was designed to test the neuroprotective effect of CAPE in 3-nitropropionic acid (3NP)-induced striatal neurotoxicity, a chemical model of Huntington’s disease (HD). Initially, to test CAPE’s antioxidant activity, a 2,2’-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) antioxidant assay was employed, and CAPE showed a strong direct radicalscavenging eff...
88.

NecroX-5 protects mitochondrial oxidative phosphorylation capacity and preserves PGC1α expression levels during hypoxia/ reoxygenation injury

VuThiThu, HyoungKyuKim, LeThanhLong, BayalagmaaNyamaa, In-SungSong, ToThanhThuy, NguyenQuangHuy, JubertMarquez, SoonHaKim, NariKim, KyungS 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 9 201-211 (11 pages)

VuThiThu, HyoungKyuKim, LeThanhLong, BayalagmaaNyamaa, In-SungSong, ToThanhThuy, NguyenQuangHuy, JubertMarquez, SoonHaKim, NariKim, KyungS 저
...
- 4,000원
Although the antioxidant and cardioprotective effects of NecroX-5 on various in vitro and in vivo models have been demonstrated, the action of this compound on the mitochondrial oxidative phosphorylation system remains unclear. Here we verify the role of NecroX-5 in protecting mitochondrial oxidative phosphorylation capacity during hypoxia-reoxygenation (HR). Necrox-5 treatment (10 μM) and non-treatment were employed on isolated rat hearts during hypoxia/ reoxygenation treatment using an ex...
89.

Inducibility of human atrial fibrillation in an in silico model reflecting local acetylcholine distribution and concentration

MinkiHwang, Hyun-SeungLee, Hui-NamPak, EunBoShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 14 111-117 (7 pages)

MinkiHwang, Hyun-SeungLee, Hui-NamPak, EunBoShim 저
...
- 3,000원
Vagal nerve activity has been known to play a crucial role in the induction and maintenance of atrial fibrillation (AF). However, it is unclear how the distribution and concentration of local acetylcholine (ACh) promotes AF. In this study, we investigated the effect of the spatial distribution and concentration of ACh on fibrillation patterns in an in silico human atrial model. A human atrial action potential model with an ACh-dependent K+ current (IKAch) was used to examine the effect of vagal...
90.

Pitavastatin Regulates Ang II Induced Proliferation and Migration via IGFBP-5 in VSMC

YuMiHa, Ju-OckNam, YoungJinKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.6 4 499-506 (8 pages)

YuMiHa, Ju-OckNam, YoungJinKang 저
...
- 3,000원
hypertensive, causes structural changes in the arteries (vascular remodeling), which involve alterations in cell growth, vascular smooth muscle cell (VSMC) hypertrophy. Ang II promotes fibrotic factor like IGFBP5, which mediates the profibrotic effects of Ang II in the heart and kidneys, lung and so on. The purpose of this study was to identify the signaling pathway of IGFBP5 on cell proliferation and migration of Ang II-stimulated VSMC. We have been interested in Ang II-induced IGFBP5 and were...

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