Primary hepatic tuberculosis is extremely rare, but liver and spleen involvement secondary to tuberculosis is frequent and of clinical importance, because of its demonstrability by biopsy. Complete absence of Tc99m-Sulfur Colloid uptake of spleen due to splenic tuberculosis has not been reported. We experienced one case of liver and spleen tuberculosis which revealed complete absence of Tc99m-Sulfur Colloid uptake in spite of huge spleen on ultrasonogram and angiogram, and 3 cases of primary-and 4 cases of secondary-hepatic tuberculosis. The findings of Tc99m-Sulfur Colloid liver-spleen scan of these 8 cases are reported with a review of the literature.