In this paper, the error rate performance of L-level amplitude shift keying (ASK), M-ary phase shift keying (PSK) and amplitude phase keying (APK) systems have been studied in the presence of interference and noise. Using the derived error probability equations, the error rate performance of each L-level ASK and M-ary PSK system has been evaluated in terms of carrier-to-noise power ratio (CNR), carrier-to-interferer power ratio (CIR), and envelope distribution of interferer. These results are combined and then the error rate performance of APK signal has been found. Finally, the error rate performance is compared and discussed.